Publications by authors named "Yumi Mikami"
Article Synopsis
- During macrophage infection, Legionella pneumophila releases proteins that transform the host's vacuoles into structures similar to the endoplasmic reticulum (ER) to replicate.
- The key effector protein Lpg1137 acts as a serine protease, specifically targeting and cleaving syntaxin 17, a protein crucial for mitochondrial function and dynamics.
- This cleavage disrupts communication between the ER and mitochondria, ultimately inhibiting autophagy and preventing apoptosis in infected cells.
