Publications by authors named "Yumi Matsuda-Matsukawa"
Article Synopsis
- KetoC is a bioactive metabolite produced by intestinal bacteria that shows potential benefits, specifically in the context of periodontitis, although its exact role was previously unclear.
- In a study using mice, researchers found that KetoC significantly reduced bone destruction and suppressed the growth of the harmful bacteria Porphyromonas gingivalis, which is linked to periodontitis.
- The study concluded that KetoC's antimicrobial properties could make it a valuable treatment option for periodontitis in clinical settings.
Article Synopsis
- The study aimed to explore the relationship between urine biomarkers and periodontitis, a gum disease, in a Japanese male population, focusing on nine urine markers often tied to kidney issues.
- Two specific biomarkers, β-microglobulin (β-MG) and neutrophil gelatinase-associated lipocalin (NGAL), were found to significantly correlate with clinical signs of periodontitis, indicating their potential as indicators of the disease's severity.
- High levels of β-MG and NGAL were particularly prevalent in patients with severe periodontitis, suggesting these urine biomarkers might be useful in assessing the condition and its relationship to systemic health issues.
Pro-protein convertase subtilisin/kexin type 9 (PCSK9), a secreted serine protease, regulates serum low-density lipoprotein (LDL) cholesterol levels by targeting the degradation of LDL receptor (LDLR) in the liver. Although previous reports describe elevated levels of PCSK9 in patients with periodontitis, the mechanisms that trigger this increase in serum PCSK9 levels and induce the related inflammatory response remain unclear. In an -deficient mouse of infection, nucleic acid antigen recognition via Toll-like receptors was found to promote PCSK9 production, suggesting an indirect role for tumor necrosis factor-α as an inducer of PCSK9 in contrast to that reported in previous studies.
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