Publications by authors named "Yumi Banba"
Background: The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding "cargo" proteins. However, it is unknown whether these "cargo" proteins influence the JIP1-kinesin-1 binding.
View Article and Find Full Text PDFStudies using cultured neurons have established the critical role of microtubule regulators in neuronal polarization. The c-Jun N-terminal kinase (JNK) pathway is one of the candidate signaling pathways driving microtubule regulation during neuronal polarization. However, the significance of the JNK pathway in axon formation, a fundamental step in neuronal polarization, in vivo, remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- Mammalian brain development relies on the movement and growth of newly formed neurons, which is regulated by an unspecified molecular mechanism.
- Dual leucine zipper kinase (DLK) is crucial for forming axon pathways from neocortical neurons, as shown through gene targeting studies in mice.
- Disruption of the DLK gene and the use of a JNK inhibitor both interfere with the migration speed of pyramidal neurons, indicating that DLK influences this process by affecting JNK activity.