Publications by authors named "Yumeng Xing"

Article Synopsis
  • The study aims to enhance the diagnosis of mitral valve prolapse (MVP) by using an automated approach that combines multi-view echocardiography and deep learning, addressing limitations of traditional methods.
  • Researchers trained two types of deep learning models (view-specific and view-agnostic) on echocardiographic data, achieving high diagnostic accuracy for both fibroelastic deficiency (FED) and Barlow's disease (BD).
  • The results suggest that this AI-driven diagnostic method significantly improves efficiency and accuracy, indicating its potential for future clinical applications in diagnosing heart valve diseases.
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Article Synopsis
  • Nanotechnology is showing great promise in clinical applications, primarily as drug delivery systems, but there's a need to explore their ability to regulate biological processes directly.
  • This research introduces lysosomal-targeting aggregated nanoparticles (LTANP) designed to treat cancer by causing lysosomal swelling and disrupting cancer cell membranes, effectively triggering immunogenic cell death.
  • LTANP can also enhance the effects of existing immunotherapies, improving T cell responses and offering a new approach to cancer treatment by reversing tumor immunogenicity.
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Mild photothermal therapy (M-PTT) can induce immunogenic cell death (ICD) to reverse the immune tolerance caused by low-dose chemotherapy. However, it still needs convenient strategies to control temperature during M-PTT. In this work, the phase change material lauric acid (LA, melting point 43 °C) was introduced to construct nanoparticles loaded with deferoxamine mesylate (DFO) and cisplatin (CDDP), which were mixed into a supramolecular hydrogel formed by polyvinylpyrrolidone (PVP)/tannic acid (TA)/Fe to obtain FeTP@DLD/DLC.

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As an essential intracellular immune activation pathway, the cGAS-STING pathway has attracted broad attention in cancer treatment. However, low bioavailability, nonspecificity, and adverse effects of small molecule STING agonists severely limit their therapeutic efficacy and in vivo application. In this study, a peptide-based STING agonist is first proposed, and KLA is screened out to activate the cGAS-STING pathway by promoting mitochondrial DNA (mtDNA) leakage.

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Background: Coronary slow flow phenomenon (CSFP) can cause left ventricular diastolic dysfunction (LVDD). In multiple studies, the left atrial (LA) strain has been reported to be an excellent parameter for assessing LVDD. The 4-dimensional automated LA quantification (4D Auto LAQ) dedicated to the LA was recently available.

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The specific recognition of cancer cells by the body's immune system is an essential step in initiating antitumor immunity. However, the decreased expression of major histocompatibility complex class I (MHC-1) and overexpression of programmed death ligand 1 (PD-L1) causes insufficient tumor-associated antigens presentation and inactivation of T cells, which accounts for poor immunogenicity. To remodel tumor immunogenicity, herein, a dual-activatable binary CRISPR nanomedicine (DBCN) that can efficiently deliver a CRISPR system into tumor tissues and specifically control its activation is reported.

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Background: There is a paucity of literature focusing left atrium (LA) in patients undergoing maintenance hemodialysis (MHD).

Hypothesis: We used three-dimensional speckle tracking echocardiography (3DSTE) to evaluate LA in MHD patients and to explore its predictive value for adverse outcomes.

Methods: Echocardiography was performed on 130 consecutively enrolled MHD patients without previous cardiac diseases.

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Background: At present, little research concerning the assessment of left atrial (LA) dysfunction in patients with obstructive sleep apnea (OSA) using a combined assessment by speckle tracking (STE) and real-time three-dimensional echocardiography (RT3DE) is available. The objective of this study was to evaluate the LA volume and function by STE and RT3DE in patients with OSA.

Methods: In our cohort study, ninety-two OSA patients and 50 healthy individuals were enrolled.

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While poly(acyclic orthoester)s (PAOEs) have many appealing features for drug delivery, their application is significantly hindered by a lack of facile synthetic methods. Reported here is a simple method for synthesizing acyclic diketene acetal monomers from diols and vinyl ether, and their polymerization with a diol to first synthesize PAOEs. The PAOEs rapidly hydrolyze at lysosomal pH.

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This study aimed to evaluate the left atrial (LA) volume and phasic functions using real-time three-dimensional echocardiography (RT3DE) in coronary slow flow phenomenon (CSFP) patients with preserved left ventricular ejection fraction (LVEF). 56 patients with CSFP (36 males, 20 females) and 48 controls with normal coronary flow (27 males, 21 females) were prospectively enrolled. Comprehensive transthoracic echocardiographic examination and RT3DE for the assessment of LA dynamics were performed in all participants.

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Previous studies reported a controversial left ventricular (LV) function impairment and pathophysiology in patients with coronary slow flow (CSF). Greater arterial load has been shown to increase aortic impedance and endothelial shear stress, potentially affecting coronary anatomy and function. We investigated LV systolic function by a new layer-specific strain technology and assessed the association between pulsatile arterial load and contractility.

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Objective: This study aimed to determine whether STE could help detect subclinical myocardial dysfunction in patients with CSFP.

Methods: Sixty patients with CSFP confirmed by CAG and 51 controls with normal coronary flow were prospectively enrolled. Coronary angiographic data and conventional and speckle tracking echocardiographic parameters of the LV and RV were obtained for every subject.

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