Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation.

Organ-on-a-chip technology is attracting growing interest across various domains as a crucial platform for drug screening and testing and is set to play a significant role in precision medicine research. Lymph nodes, being intricately structured organs essential for the body's adaptive immune responses to antigens and foreign particles, are pivotal in assessing the immunotoxicity of novel pharmaceuticals. Significant progress has been made in research on the structure and function of the lymphatic system.

Thoracic splenosis presenting as pulmonary space-occupying lesion.

Background: Spleen leaves its normal anatomical position and appears in other locations, which is called ectopic spleen. It is most commonly found in the abdomen or pelvis with seeding of the peritoneum, omentum or mesentery. A few of cases of thoracic splenosis associated with traumatic diaphragmatic rupture have been reported.

Temperature-dependent stability and DPPH scavenging activity of liposomal curcumin at pH 7.0.

This paper investigated the influences of temperature on the stability and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of curcumin encapsulated in liposome at pH 7.0. Liposomal curcumin showed higher stability and DPPH scavenging activity than free curcumin at 25°C.

Effects of curcumin concentration and temperature on the spectroscopic properties of liposomal curcumin.

The spectroscopic properties of liposomal curcumin in pH 7.0 sodium phosphate buffer were studied at various curcumin concentrations and temperatures. At 25 °C, liposomal curcumin exhibited much higher values than free curcumin in absorption maximum, fluorescence maximum, and fluorescence anisotropy.

Spectrometric study on the interaction of dodecyltrimethylammonium bromide with curcumin.

The interaction between dodecyltrimethylammonium bromide (DTAB) and curcumin has been studied in pH 5.0 sodium phosphate buffer using absorption and fluorescence measurements. With increasing DTAB concentration (C(DTAB)) from 0 to 20 mM, the absorption peak of curcumin at 430 nm, corresponding to the conjugated structure of curcumin, first weakens gradually into a shoulder but increases back into one peak with much higher absorption intensity.