Large deviation principle for the mean reflected stochastic differential equation with jumps.

In this paper, we establish a large deviation principle for a mean reflected stochastic differential equation driven by both Brownian motion and Poisson random measure. The weak convergence method plays an important role.

Does chronic ankle instability influence lower extremity muscle activation of females during landing?

Much remains unclear about how chronic ankle instability (CAI) could affect knee muscle activations and interact with knee biomechanics. Therefore, the purpose of this study was to assess the influence of CAI on the lower extremity muscle activation at the ankle and knee joints during landings on a tilted surface. A surface electromyography system and two force plates were used to collect lower extremity muscle activation of 21 young female individuals with CAI and 21 pair-matched controls during a double-leg landing with test limb landing on the tilted surface.

Diagnostic Accuracy of the Chinese Version of the Trail-Making Test for Screening Cognitive Impairment.

Background/objectives: The Trail-Making Test (TMT), which is commonly used to measure executive function, consists of two components (TMT-A and TMTB). There is a lack of normative TMT data for Chinese elderly adults. This study aimed to evaluate the validity of the TMT in screening for cognitive impairment.

Spine kinematics exhibited during the stop-jump by physically active individuals with adolescent idiopathic scoliosis and spinal fusion.

Background Context: Individuals with adolescent idiopathic scoliosis post spinal fusion often return to exercise and sport. However, the movements that individuals with spinal fusion for adolescent idiopathic scoliosis (SF-AIS) use to compensate for the loss of spinal flexibility during high-effort tasks are not known.

Purpose: The objective of this study was to compare the spinal kinematics of the trunk segments displayed during the stop-jump, a maximal effort task, between SF-AIS and healthy control groups.

Protection from Psoriasis-Related Thrombosis after Inhibition of IL-23 or IL-17A.

Psoriasis patients experience chronic systemic skin inflammation and develop cardiovascular comorbidities that shorten their lifespan. Whether cardiovascular disease is improved by treatment with current biologics that target disease-specific pathways is unclear. KC-Tie2 mice develop psoriasiform skin inflammation with increases in IL-23 and IL-17A and proinflammatory monocytosis and neutrophilia that precedes development of carotid artery thrombus formation.

Risk Assessment of Hepatocellular Carcinoma in Patients with Hepatitis C in China and the USA.

Background: Hepatitis C (HCV) infection is an increasingly common cause of hepatocellular carcinoma (HCC) in China.

Aims: We aimed to determine differences in demographic and behavioral profiles associated with HCC in HCV+ patients in China and the USA.

Methods: Consecutive HCV+ patients were recruited from centers in China and the USA.

Lower extremity kinematics of curve sprinting displayed by runners using a transtibial prosthesis.

The purpose of the study was to determine if the kinematics exhibited by skilled runners wearing a unilateral, transtibial prosthesis during the curve section of a 200-m sprint race were influenced by interaction of limb-type (prosthetic limb (PROS-L) vs. nonprosthetic limb (NONPROS-L)) and curve-side (inside and outside limb relative to the centre of the curve). Step kinematics, toe clearance and knee and hip flexion/extension, hip ab/adduction for one stride of each limb were generated from video of 13 males running the curve during an international 200 m transtibial-classified competition.

The vascular protective effects of Anoectochilus roxburghii polysaccharose under high glucose conditions.

Ethnopharmacological Relevance: Anoectochilus roxburghii has been used as a health food and a herb for treatment diabetes in China for hundreds years. Anoectochilus roxburghii polysaccharose (ARP) is the major active component of the plant.

Aim Of The Study: The present study investigated the vascular protection of ARP in vivo and in vitro experiments.

[Protective effects of dimethyl sulfoxide on zymosan-insulted gut barrier impairment].

Objective: To explore the effect of dimethyl sulfoxide(DMSO) on suppressing the release of gut inflammatory cytokine and re-store of the barrier impairment following zymosan-insulted systemic inflammatory response syndrome (SIRS).

Methods: S D rats were randomly divided into four groups:sham with administration of normal saline (SS group); sham with administration of DMSO (DS group); zymosan with administration of normal saline (ZS group); and zymosan with administration of DMSO (ZD group), each group includes two subgroups at 4 h and 24 h after surgery. At 4 h and 24 h after intraperitoneal injection of zymosan (750 mg/kg), the levels of intestinal inflammatory cytokines (tumor necrosis factor-αand interleukin-10) and the activity of diamine oxidase in plasma were examined.

[Inhibitory effect and mechanism of deoxyschizandrin on NLRP3 inflammasome].

This study was conducted to investigate the inhibitory effect and the molecular mechanism of deoxyschizandrin on the activity of NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome. Bone marrow-derived macrophages were used to study the effects of deoxyschizandrin on inflammasome activation using inflammasome inducers (ATP and nigericin). Cytotoxic effect was evaluated with CCK-8.

Quantifying Inter-Segmental Coordination during the Instep Soccer Kicks.

In order to generate a high ball speed in soccer, the inter-segmental coordination of the kicking leg is critical. The purpose of this study was to quantify the coordination between the thigh and shank movement in the sagittal plane during instep kicks. Eleven female soccer players were video recorded using a high-speed (80 Hz) video camera during penalty kicks.

[Electroacupuncture at "Zusanli" (ST 36) Alleviates Myocardium Damage in Intestinal Ischemia-reperfusion Rats by Up-regulating Periphery Dopamine Level].

Objective: To observe the effect of electroacupuncture (EA) of "Zusanli" (ST 36) on myocardium ischemic damage following intestinal ischemia-reperfusion (I/R) in rats.

Methods: Thirty SD rats were randomly divided into five groups:sham, I/R-1 h, I/R-4 h, EA-I/R-1 h and EA-I/R-4 h (=6 in each group). The intestinal I/R model was established by occlusion of the superior mesenteric artery.

Untargeted Metabolomics Reveals Dose-Response Characteristics for Effect of Rhubarb in a Rat Model of Cholestasis.

Cholestasis is a serious manifestation of liver diseases with limited therapies. Rhubarb, a widely used herbal medicine, has been frequently used at a relatively large dose for treating cholestasis. However, whether large doses are optimal and the therapeutic mechanism remain unclear.

Different intracellular signalling properties induced by human and porcine growth hormone.

Growth hormone (GH) is reportedly species-specific. Primate growth hormone can trigger non-primate growth hormone receptor (GHR), but primates GHR cannot be activated by non-primate GH. However, it is also unclear that why primate GH and non-primate GH have different biological activities.

[Influence of specification on chemical composition of dissolution and hepatocytes toxicity of Polygonum multiflorum].

According to different toxicities of various aqueous extracts of Polygonum multiflorum on hepatocyte, the impacts of chemical composition on the safety of P. multiforum was studied. In this study, 8 main chemical compositions in aqueous extracts of P.

The renal protective effects of Anoectochilus roxburghii polysaccharose on diabetic mice induced by high-fat diet and streptozotocin.

Ethnopharmacological Relevance: Anoectochilus roxburghii (Wall.) Lindl. 1832 is an herbal medicine used to treat diabetes in China.

Dimethyl sulfoxide inhibits zymosan-induced intestinal inflammation and barrier dysfunction.

Aim: To investigate whether dimethyl sulfoxide (DMSO) inhibits gut inflammation and barrier dysfunction following zymosan-induced systemic inflammatory response syndrome and multiple organ dysfunction syndrome.

Methods: Sprague-Dawley rats were randomly divided into four groups: sham with administration of normal saline (SS group); sham with administration of DMSO (SD group); zymosan with administration of normal saline (ZS group); and zymosan with administration of DMSO (ZD group). Each group contained three subgroups according to 4 h, 8 h, and 24 h after surgery.

FLT3 mutational status is an independent risk factor for adverse outcomes after allogeneic transplantation in AML.

Allogeneic hematopoietic cell transplantation (HCT) has been increasingly used in the setting of FMS-like tyrosine kinase-3 (FLT3)-mutated AML. However, its role in conferring durable relapse-free intervals remains in question. Herein we sought to investigate FLT3 mutational status on transplant outcomes.

Allogeneic transplantation with myeloablative FluBu4 conditioning improves survival compared to reduced intensity FluBu2 conditioning for acute myeloid leukemia in remission.

The optimal intensity of conditioning for allogeneic hematopoietic stem cell transplantation (HCT) in acute myeloid leukemia (AML) remains undefined. Traditionally, myeloablative conditioning regimens improve disease control, but at the risk of greater nonrelapse mortality. Because fludarabine with myeloablative doses of intravenous busulfan using pharmacokinetic monitoring has excellent tolerability, we reasoned that this regimen would limit relapse without substantially elevating toxicity when compared to reduced intensity conditioning.

Factors contributing to facial asymmetry in identical twins.

Background: This study examines the potential contributions of environmental factors to variations in facial symmetry between identical twins.

Methods: Identical male and female twins were recruited from the Twins Days Festival in 2009 and 2010. Subjects independently completed a comprehensive questionnaire on their medical and personal history, and then posed for digital facial photography from several different angles.