Publications by authors named "Yuma Tsuruta"
Article Synopsis
- The study aimed to evaluate the effectiveness of AI-assisted digital image analysis for assessing Ki-67 levels in invasive breast carcinoma (IBC) by analyzing the accuracy and performance of a deep-learning model.
- Researchers constructed two models (DL-TC and DL-ND) using a large dataset of Ki-67 slide images and found that the models performed well in identifying cancerous tissue and correlating with manual counts of Ki-67.
- The results indicated that higher Ki-67 index levels were associated with poorer patient outcomes, confirming that this AI-based analysis could potentially enhance prognostic assessments in breast cancer.
We describe an unusual case of multifocal breast adenoid cystic carcinoma (AdCC) with adenomyoepitheliomatous morphology. Most breast AdCCs are unifocal and only four cases of multifocal AdCC have been reported previously, however, to our best knowledge, multifocality in AdCC confirmed by molecular analysis has not been reported, so this report adds to the literature on this unique presentation. An 80-year-old woman presented with a left breast mass at 1 o'clock and non-mass enhancement lesion at 5 o'clock on imaging.
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- Adult T-cell leukemia/lymphoma (ATLL) is a type of T-cell cancer linked to the HTLV-1 virus, characterized by specific immunophenotypes outlined by the 2017 WHO classification which includes several positive and negative markers.
- A study assessing immunohistochemical profiles in 117 ATLL cases revealed that 20% did not fit the typical immunophenotype, with significant findings such as high rates of TCR negativity and associations between specific markers and morphological characteristics.
- No single immunophenotypic marker was found to be predictive of overall survival in ATLL patients, highlighting the complexity of the disease and the need for further research into its diverse profiles.
A 44-year-old woman with a 26-year history of Crohn's disease (CD) presented with intermittent fever, vomiting, and watery diarrhea. Her medication included an elemental diet, mesalazine, and infliximab. Liver profile and viral hepatitis markers were normal.
View Article and Find Full Text PDFHodgkin and Reed-Sternberg (HRS) cells, a hallmark of classic Hodgkin lymphoma (CHL), are occasionally detected in non-Hodgkin lymphomas, including adult T-cell leukemia/lymphoma (ATLL), a lymphoid neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). HRS-like cells associated with ATLL have been described to be of B-cell lineage and infected with Epstein-Barr virus (EBV), not HTLV-1. We herein describe clinicopathological findings in 8 cases (4 males and 4 females; median age, 73 years [range, 55-81 years]) of ATLL with HTLV-1-infected HRS-like cells identified by ultrasensitive RNA in situ hybridization for HTLV-1 basic leucine zipper factor (HBZ-ISH), a specific viral transcript of HTLV-1.
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