A Real-Time Cell Death Self-Reporting Theranostic Agent for Dynamic Optimization of Photodynamic Therapy.

The therapeutic efficiency of photodynamic therapy (PDT) hinges on the drug-light interval (DLI), yet conventional approaches relying on photosensitizer accumulation often lead to suboptimal irradiation and adverse side effects. Here, a real-time cell death self-reporting photodynamic theranostic nanoagent (CDPN) is presented that dynamically monitors extracellular potassium ion ([K⁺]) fluctuations as direct indicators of tumor cell death. By exploiting [K⁺] dyshomeostasis associated with apoptosis and necrosis, CDPN combines a photosensitizer and a potassium-sensitive fluorophore within mesoporous silica nanoparticles, encapsulated by a K⁺-selective membrane for enhanced specificity.

Coprecipitates between iron oxides and biodegradable organic acids for boosting Fenton-like catalysis under neutral pH conditions.

While the role of dissociated and complexed forms of organic acids (OAs) on Fenton-like reactions has been widely investigated, the catalytic ability and detailed mechanisms of coprecipitates between iron oxides and OAs were still obscure. Herein, coprecipitates of iron oxides with eco-friendly organic acids including maleic acid (MAA), tetrasodium-N,N-bis(carboxymethyl)-L-glutamate (GLDA), and protocatechuic acid (PCA) possessing different C/Fe molar ratios (OA-FeO, x: C/Fe molar ratios) were respectively prepared under ambient conditions. The coprecipitates exhibited eminent Fenton-like performance in removing various pollutants (e.

Progress in African Swine Fever Vector Vaccine Development.

African swine fever (ASF) is a highly lethal, infectious, hemorrhagic fever disease, characterized by an acute mortality rate approaching 100%. It is highly contagious, and results in significant losses to the global hog industry as it spreads. Despite incremental progress in research on the African swine fever virus (ASFV), a safe and effective commercial vaccine has yet to be developed.

Ecological drought sensitivity assessment of winter wheat in the Huang-Huai-Hai plain, China.

Drought events are complex and uncertain, and drought sensitivity assessments are beneficial for ecological conservation and improving early warning mechanisms. Understanding ecosystems' response to drought is vital for ecological conservation and climate change research. Ecological drought, a concept describing drought from an ecosystem perspective, lacks sufficient research regarding its effects on agricultural ecosystems, especially in the Huang-Huai-Hai Plain.

Associations of physical activity and mental health in pregnant women: A cross-sectional isotemporal substitution analysis.

Background: Prenatal mental health is an increasing public concern. At present, it has been shown that increasing physical activity (PA) is effective in promoting mental health of pregnant women. However, mental health may depend not only on the amount of time spent on a specific activity, but also on the intensity and type of the activity that it replaces.

Designing High Content Carbonylated β-Cyclodextrin/PBI Mixed Matrix Membrane as HT-PEM to Reduce HPO Loss.

The high-temperature proton exchange membranes suffer from weak binding strength for phosphoric acid molecules, which seriously reduce the fuel cell efficiency, especially operation stability. Introduction of microporous material in the membrane can effectively reduce the leaching of phosphoric acid. However, due to the poor compatibility between the polymer and fillers, the membrane's performance significantly reduced at high fillers content.

Phenomics-assisted genetic dissection and molecular design of drought resistance in rice.

Dissecting the mechanism of drought resistance (DR) and designing drought-resistant rice varieties are promising strategies to address the challenge of climate change. Here, we selected a typical drought-avoidant (DA) variety, IRAT109, and a drought-tolerant (DT) variety, Hanhui15, as parents to develop a stable recombinant inbred line (RIL) population (F, 1262 lines). The de novo assembled genomes of both parents were released.

The Distribution and Therapeutic Effectiveness of Clinical Unilateral Ménière's Disease Phenotypes.

Objectives: The first purpose of this study was to ascertain the distribution of unilateral Ménière's disease (MD) clinical subgroups in China and compare with the population reported in Europe and the United States. The second purpose was to investigate the effectiveness in different clinical phenotypes.

Methods: Participants were categorised into one of five subtypes using a previously reported classification scheme based on cluster analysis.

Aptamer modified CeCo MOF hybrid catalysts with multiple enzymatic activities for enhanced catalytic therapy of infected wounds.

Designing and inventing synergistic emerging antimicrobial strategies is critical for mitigating potential resistance to conventional antibiotics. This task is challenging because these antimicrobial agents should need to eliminate bacteria, slow oxidative stress in wounds, and be safe and nontoxic. Here, we report a highly safe antimicrobial nanocatalyst for bacterial scavenging through aptamer-synergistic multienzyme activity.

Nano boron carbide effectively boost Fenton-like performance of hematite mediated systems: Roles of hematite exposed facets and synergistic catalysis between Fe and B.

The inherent properties of exposed facets of iron minerals played key roles in heterogeneous reactions at the mineral interface, and the addition of co-catalysts has been elucidated to further enhance the reactions for contaminants degradation. Here, synergistic Fenton-like catalytic reactivity of different hematite dominant exposed facets ({001}, {012}, {100}, and {113}) with nano boron carbide (BC) was revealed. In 5 h, as compared with the cumulative •OH in the BC/HO system (96.

LncRNA HIF1A-AS2 promotes triple-negative breast cancer progression and paclitaxel resistance via MRPS23 protein.

Dysregulation of lncRNAs is a critical factor in the migration and invasion of tumors. Here our study reveals that lncRNA HIF1A-AS2 is highly expressed in breast cancer tissues and various TNBC cell lines. Moreover, we present compelling evidence supporting the role of HIF1A-AS2 in promoting TNBC cell proliferation, metastasis, invasion, and resistance to paclitaxel treatment.

The Impact of Adjuvant Chemotherapy on the Long-Term Prognosis of Breast Malignant Phyllodes Tumors: A Propensity Score-Matched Study.

Background: Malignant phyllodes tumors (MPTs) are rare breast tumors with high risks of local recurrence and distant metastasis. Surgical intervention is the primary treatment, but the effectiveness of adjuvant therapies is uncertain. This study was designed to analyze the prognostic risk factors associated with MPTs and evaluate the efficacy of postoperative adjuvant chemotherapy.

Decarboxylative Cyclization of Ethynyl Benzoxazinanones with Imidazolidines to Access 2,3-Indole-Fused 1,4-Diazocines.

2,3-Indole-fused 1,4-diazocines represent a new family of indole alkaloid compounds and are difficult to access by the reported protocols. Herein, we report a copper-catalyzed decarboxylative cyclization of cyclic propargylic carbamates with imidazolidines via sequential C-N/C-N/C-C bond formation to deliver a series of 2,3-indole-fused 1,4-diazocines, with a broad substrate scope and mild conditions.

PROTACs targeting androgen receptor signaling: Potential therapeutic agents for castration-resistant prostate cancer.

After the initial androgen deprivation therapy (ADT), part of the prostate cancer may continuously deteriorate into castration-resistant prostate cancer (CRPC). The majority of patients suffer from the localized illness at primary diagnosis that could rapidly assault other organs. This disease stage is referred as metastatic castration-resistant prostate cancer (mCRPC).

Iridium-Catalyzed Regio- and Enantioselective -Allylation of Pyrazoles with Dienyl/Monoallylic Alcohols.

Here we report the first example of iridium-catalyzed asymmetric -allylation of pyrazoles with dienyl allylic alcohols under mild conditions with broad functional group tolerance, exhibiting excellent /C3-site selectivities and enantioselectivities (up to >99% ee). In addition to pyrazoles, other nucleophiles including benzotriazole, triazole, and pyrazole precursors (aryl vinyldiazos) are also suitable in this method. Notably, with the use of Sc(OTf) as additive and reactions performed at 30 °C for 24 h, the -C5 or -C1 selective alkylated pyrazoles are also obtained.

Polymeric liposomes targeting dual transporters for highly efficient oral delivery of paclitaxel.

A novel delivery system comprising N-succinic anhydride (N-SAA) and D-fructose co-conjugated chitosan (NSCF)-modified polymeric liposomes (NSCF-PLip) were designed to enhance oral delivery of paclitaxel (PTX) by targeting monocarboxylate transporters (MCT) and glucose transporters (GLUT). The synthesized NSCF was characterised by FT-IR and H NMR spectra. The prepared 30.

CNN and Attention-Based Joint Source Channel Coding for Semantic Communications in WSNs.

Wireless Sensor Networks (WSNs) have emerged as an efficient solution for numerous real-time applications, attributable to their compactness, cost-effectiveness, and ease of deployment. The rapid advancement of 5G technology and mobile edge computing (MEC) in recent years has catalyzed the transition towards large-scale deployment of WSN devices. However, the resulting data proliferation and the dynamics of communication environments introduce new challenges for WSN communication: (1) ensuring robust communication in adverse environments and (2) effectively alleviating bandwidth pressure from massive data transmission.

Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation.

Peptide-protected gold nanoclusters (AuNCs), possessing exceptional biocompatibility and remarkable physicochemical properties, have demonstrated intrinsic pharmaceutical activity in immunomodulation, making them a highly attractive frontier in the field of nanomedicine exploration. Autoimmune hepatitis (AIH) is a serious autoimmune liver disease caused by the disruption of immune balance, for which effective treatment options are still lacking. In this study, we initially identified glutathione (GSH)-protected AuNCs as a promising nanodrug candidate for AIH alleviating in a Concanavalin A (Con A)-induced mice model.

Corrigendum: Identification of differentially expressed hub genes associated with immune cell recruitment in claudin-low breast cancer.

[This corrects the article DOI: 10.3389/fonc.2022.

Experimental and DFT insights into the adsorption mechanism of methylene blue by alkali-modified corn straw biochar.

As an efficient and cost-effective adsorbent, biochar has been widely used in the adsorption and removal of dyes. In this study, a simple NaOH-modified biochar with the pyrolysis temperature of 300 °C (NaCBC) was synthesized, characterized, and investigated for the adsorption performances and mechanisms of methylene blue (MB). NaCBC exhibited excellent MB adsorption performance with maximum removal efficiency and adsorption capacity of 99.

Association Between Social Support, and Depressive Symptoms Among Firefighters: The Mediating Role of Negative Coping.

Background: Depressive symptoms (DS) can erode physical and mental health; social support (SS) is considered a buffer for DS and a promoter for improving coping and recovery abilities. However, there is almost no research on the mediating role of negative coping (NC) in SS and DS, especially among firefighters.

Methods: A cross-sectional survey was conducted among firefighters in Chongqing, China, and the valid data of 407 firefighters were collected through questionnaires distributed on the WeChat platform in 2020.

A lightweight YOLOv7 insulator defect detection algorithm based on DSC-SE.

As the UAV(Unmanned Aerial Vehicle) carrying target detection algorithm in transmission line insulator inspection, we propose a lightweight YOLOv7 insulator defect detection algorithm for the problems of inferior insulator defect detection speed and high model complexity. Firstly, a lightweight DSC-SE module is designed using a DSC(Depthwise Separable Convolution) fused SE channel attention mechanism to substitute the SC(Standard Convolution) of the YOLOv7 backbone extraction network to decrease the number of parameters in the network as well as to strengthen the shallow network's ability to obtain information about target features. Then, in the feature fusion part, GSConv(Grid Sensitive Convolution) is used instead of standard convolution to further lessen the number of parameters and the computational effort of the network.

Synergistic wound repair effects of a composite hydrogel for delivering tumor-derived vesicles and -nitrosoglutathione.

Treating chronic wounds requires transition from proinflammatory M1 to anti-inflammatory M2 dominant macrophages. Based on the role of tumor extracellular vesicles (tEVs) in regulating the phenotypic switching from M1 to M2 macrophages, we propose that tEVs may have a beneficial impact on alleviating the overactive inflammatory microenvironment associated with refractory wounds. On the other hand, as a nitric oxide donor, -nitrosoglutathione (GSNO) can regulate inflammation, promote angiogenesis, enhance matrix deposition, and facilitate wound healing.