Clinicopathological and Molecular Profile of Sellar Neurocytoma.

Objective: To investigate the clinical features, imaging characteristics and molecular profile of Sellar neurocytoma (SN).

Methods: Clinical, imaging, and pathological features of eleven cases of sellar neurocytoma were retrospectively analyzed. Electron microscopy was performed in five cases.

Identification of biomarkers associated with the invasion of nonfunctional pituitary neuroendocrine tumors based on the immune microenvironment.

Introduction: The invasive behavior of nonfunctioning pituitary neuroendocrine tumors (NF-PitNEts) affects complete resection and indicates a poor prognosis. Cancer immunotherapy has been experimentally used for the treatment of many tumors, including pituitary tumors. The current study aimed to screen the key immune-related genes in NF-PitNEts with invasion.

The SF3B1 mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.

Background: Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 (SF3B1), but its functional effects and underlying molecular mechanisms remain largely unexplored.

Methods: Using the CRISPR/Cas9 genome editing system and rat pituitary GH3 cells, we generated heterozygous Sf3b1 mutant cells. Sanger and whole-genome sequencing were conducted to verify the introduction of this mutation.

A Novel Three-LncRNA Signature Predicting Tumor Recurrence in Nonfunctioning Pituitary Adenomas.

The nonfunctioning pituitary adenoma (NFPA) recurrence rate is relatively high after surgical resection. Here, we constructed effective long noncoding RNA (lncRNA) signatures to predict NFPA prognosis. LncRNAs expression microarray sequencing profiles were obtained from 66 NFPAs.

Screening and Identification of Key Microenvironment-Related Genes in Non-functioning Pituitary Adenoma.

Purpose: Non-functioning pituitary adenoma (NFPA) is a very common type of intracranial tumor, which can be locally invasive and can have a high recurrence rate. The tumor microenvironment (TME) shows a high correlation with tumor pathogenesis and prognosis. The current study aimed to identify microenvironment-related genes in NFPAs and assess their prognostic value.

Identifying critical protein-coding genes and long non-coding RNAs in non-functioning pituitary adenoma recurrence.

Non-functioning pituitary adenoma (NFPA) is a very common type of intracranial tumor. Monitoring and predicting the postoperative recurrence of NFPAs is difficult, as these adenomas do not present with serum hormone hypersecretion. Long non-coding RNAs (lncRNAs) and protein-coding genes (PCGs) play critical roles in the development and progression of numerous tumors.

A giant local interneuron modulates the rhythmic activities of the antennal lobe in Pupae Drosophila.

In Drosophila, olfaction is tightly related to feeding and reproduction. There are three classes of neurons forming synapses in the olfactory circuit: the olfactory receptor neurons (ORNs), projection neurons (PNs), and local interneurons (LNs). Here, we showed that giant local interneurons named GLNs, which were different from the classical neurons in the olfactory circuits, displayed distinctive rhythmic activities in the dorsolateral side of antennal lobe (AL) in Drosophila Pupae.