Effect of continuous infusion in alleviating pain during male urethral catheterization.

Aims: The aim of this study was to explore whether continuous infusion causing lubrication can effectively alleviate pain during male urethral catheterization.

Methods: This prospective, multicenter, double-blinded study included 190 male patients scheduled for urethral catheterization. Patients were randomly allocated into four groups: Group A: the catheter was lubricated with paraffin; Group B: the catheter was lubricated with compound lidocaine gel; Group C: the pump continuously infusing with sterilized water; Group D: the pump continuously infusing with 2% lidocaine.

Research progress on pharmacological effects and bioavailability of berberine.

Berberine (BBR), a benzylisoquinoline alkaloid obtained from natural medicines such as coptidis rhizoma, has a wide range of pharmacological activities such as protecting the nervous system, protecting the cardiovascular system, anti-inflammatory, antidiabetic, antihyperlipidemic, antitumor, antibacterial, and antidiarrheal. However, factors such as poor solubility, low permeability, P-glycoprotein (P-gp) efflux, and hepatic-intestinal metabolism result in BBR having a low bioavailability (< 1%), which restricts its application in clinical settings. Therefore, improving its bioavailability is a prerequisite for its clinical applications.

2.3-µm single-frequency Tm: ZBLAN fiber amplifier with output power of 1.41 W.

We present here the first watt-level single-frequency thulium-doped ZBLAN fiber amplifier system operating at a wavelength of 2.3 µm. Continuous-wave output of up to 1.

The effect of opioid-free anaesthesia on the quality of recovery after endoscopic sinus surgery: A multicentre randomised controlled trial.

Background: It remains to be determined whether opioid-free anaesthesia (OFA) is consistently effective for different types of surgery.

Objectives: The current study hypothesised that OFA could effectively inhibit intraoperative nociceptive responses, reduce side effects associated with opioid use, and improve the quality of recovery (QoR) in endoscopic sinus surgery (ESS).

Design: A multicentre randomised controlled study.

3.1 W mid-infrared fiber laser at 4.16 µm based on HBr-filled hollow-core silica fibers.

We present the characteristics of a continuous-wave (CW) mid-infrared fiber laser source based on HBr-filled hollow-core fibers (HCFs) made of silica. The laser source delivers a maximum output power of 3.1 W at 4.

Stimulated Raman scattering of H in hollow-core photonics crystal fibers pumped by high-power narrow-linewidth fiber oscillators.

The stimulated Raman scattering (SRS) process in gas-filled hollow-core fiber is mostly used to realize the wavelength conversion, which has the potential to produce narrow-linewidth and high-power fiber laser output. However, limited by the coupling technology, the current research is still at a few watts power level. Here, through the fusion splicing between the end-cap and the hollow-core photonics crystal fiber, several hundred watts pump power can be coupled into the hollow core.

Numerical simulation and observed rotational relaxation in CW and pulsed HBr-filled hollow-core fiber lasers.

Gas-filled hollow-core fiber (HCF) lasers have emerged as a promising technology for generating mid-infrared lasers. A four-energy level system laser model is presented to predict the performance of optically pumped HBr-filled HCF lasers under continuous wave (CW) and pulsed excitations. The steady state condition is considered in CW pumping and the characteristics of simulated population density and power distribution along HCF are investigated.

High-gain single-frequency Tm-doped ZBLAN fiber amplifier at 2.33 μm.

We report here, to the best of our knowledge, the first high-gain, single-frequency Tm-doped fiber amplifier operating at the 2.3-μm band with conventional ground-state pumping transition (H→H) at 793 nm. The gain fiber is an 8.

Effect of Ice Slush on Reducing the Oculocardiac Reflex During Strabismus Surgery.

Background: The aim of this study was to explore whether ice slush (IS) causing local hypothermia can effectively inhibit the oculocardiac reflex (OCR) during strabismus surgery.

Methods: This prospective, randomized, double-blind study included 58 patients with concomitant strabismus scheduled for lateral rectus (LR) recession under general anesthesia. Patients were randomly allocated to receive IS (IS group) or standard treatment (control group) with sterile saline at room temperature before surgery.

Mid-infrared fiber gas amplifier in acetylene-filled hollow-core fiber.

We report here the first, to the best of our knowledge, demonstration of a mid-infrared (mid-IR) fiber gas amplifier based on acetylene-filled hollow-core fibers. A quasi-all-fiber structure fiber acetylene laser in a single-pass configuration is used as a seed. The injection of the seed removes the threshold and increases the laser efficiency, which are more pronounced at high pressure.

Risk factors of perioperative acute kidney injury in elderly patients: a single-center retrospective study.

Purpose: The elderly are vulnerable to perioperative acute kidney injury. The aim of this study was to determine the risk factors that associated with acute kidney injury among elderly patients.

Methods: Clinical data of elderly patients (> 65 years) who underwent noncardiac, nonrenal surgery between Dec 1 2009 and July 1 2016 were collected for this single-centered historical cohort study.

Fiber laser source of 8 W at 3.1 µm based on acetylene-filled hollow-core silica fibers.

We report here the characteristics of a nanosecond high-power mid-infrared (mid-IR) light source based on an anti-resonant hollow-core fiber (AR-HCF) filled with acetylene gas. It is a single-pass configuration with 9.3-m HCFs, pumped by a modulated and amplified diode laser.

Combined Programmed Intermittent Bolus Infusion With Continuous Infusion for the Thoracic Paravertebral Block in Patients Undergoing Thoracoscopic Surgery: A Prospective, Randomized, and Double-blinded Study.

Background: Continuous thoracic paravertebral block (TPVB) connected with patient-controlled analgesia (PCA) pump is an effective modality to reduce postoperative pain following thoracic surgery. For the PCA settings, the programmed intermittent bolus infusion (PIBI) and continuous infusion (CI) are commonly practiced. However, the comparative effectiveness between the 2 approaches has been inconsistent.

NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia.

Infection, predominantly induced by gram-negative bacteria, is a critical health problem and a leading cause of death worldwide. Advance of techniques, such as antibiotics and life-supporting modality, allows a decreasing death rate of patients with infection in recent decades. Nevertheless, infection-associated complications, in particular cognitive dysfunction, largely influence the mortality of patients and the life quality of survivors.

Intelligent Algorithm-Based Coronary Angiography Characteristics of Acute Non-ST-Segment Elevation Myocardial Infarction Patients with Different Genders.

Objective: This study was aimed at comparing the characteristics of coronary angiography based on intelligent algorithm in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI) of different genders.

Methods: Eighty patients were selected to segment the coronary angiogram using the convolutional neural network (CNN) algorithm, the input layer of the CNN was used to receive the image dataset, and three-dimensional data were input during semantic segmentation to achieve automatic segmentation of the target features. Segmentation results were quantitatively assessed by accuracy (Acc), sensitivity (Se), specificity (Sp), and Dice coefficient (Dice).

Towards high-power mid-IR light source tunable from 3.8 to 4.5 µm by HBr-filled hollow-core silica fibres.

Fibre lasers operating at the mid-IR have attracted enormous interest due to the plethora of applications in defence, security, medicine, and so on. However, no continuous-wave (CW) fibre lasers beyond 4 μm based on rare-earth-doped fibres have been demonstrated thus far. Here, we report efficient mid-IR laser emission from HBr-filled silica hollow-core fibres (HCFs) for the first time.

All-fiber gas Raman laser oscillator.

Here, we report the first, to the best of our knowledge, all-fiber gas Raman laser oscillator (AFGRLO), which is formed by fusion splicing solid-core fibers and a hydrogen-filled hollow-core photonic crystal fiber, and further introducing fiber Bragg gratings at a Stokes wavelength. Pumping with a homemade 1.54 µm fiber amplifier seeded by a narrow linewidth diode laser, we obtain the maximum output Stokes power of 1.

Narrow-Linewidth 2 μm All-Fiber Laser Amplifier with a Highly Stable and Precisely Tunable Wavelength for Gas Molecule Absorption in Photonic Crystal Hollow-Core Fibers.

In recent years, mid-infrared fiber lasers based on gas-filled photonic crystal hollow-core fibers (HCFs) have attracted enormous attention. They provide a potential method for the generation of high-power mid-infrared emissions, particularly beyond 4 μm. However, there are high requirements of the pump for wavelength stability, tunability, laser linewidth, etc.

Baicalein attenuates acute liver injury by blocking NLRP3 inflammasome.

Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a critical health problem worldwide and lacks effective treatment. Here, we used Lipopolysaccharides (LPS)/D-galactosamine (D-gal)-treated primary hepatocytes to screen a natural library that contains 1130 chemicals. Baicalein in the library showed highest inhibitory effects against LPS/D-Gal-induced liver injury.

Pure rotational stimulated Raman scattering in H-filled hollow-core photonic crystal fibers.

We conducted comprehensive theoretical research on rotational stimulated Raman scattering (SRS) of hydrogen molecules in hollow-core fibers. A reliable model for describing the steady-state rotational SRS of hydrogen was established and the influences of various factors was investigated. To verify the theoretical model, a single-pass fiber gas Raman laser (FGRL) based on hydrogen-filled hollow-core photonic crystal fibers pumped by a 1.

Low-loss coupling from single-mode solid-core fibers to anti-resonant hollow-core fibers by fiber tapering technique.

We demonstrate here for the first time, to the best of our knowledge, an effective method to achieve low-loss light coupling from solid-core fibers to anti-resonant hollow-core fibers (AR-HCFs) by fiber tapering technique. We establish the coupling models by beam propagation method (BPM), and the simulation results show that the coupling efficiency can be optimized by choosing a proper waist diameter of the tapered solid-core fiber. Two types of AR-HCFs have been tested experimentally, and the maximum light coupling efficiency is ∼91.

The long noncoding RNA NKILA protects against myocardial ischaemic injury by enhancing myocardin expression via suppressing the NF-κB signalling pathway.

Background: The lncRNA NKILA has been reported to interact with NF-κB and has an important role in various human diseases. However, the role of NKILA in myocardial ischaemic injury is still unknown.

Methods: We established cell and animal models of myocardial ischaemic injury.

High-efficiency laser wavelength conversion in deuterium-filled hollow-core photonic crystal fiber by rotational stimulated Raman scattering.

We report here, to the best of our knowledge, for the first time high-efficiency laser wavelength conversion from 1.5 µm band to 1.7 µm band in deuterium-filled hollow-core photonic crystal fibers by rotational stimulated Raman scattering (SRS).