Rational Design of 3D Polymer Corona Interfaces of Single-Walled Carbon Nanotubes for Receptor-Free Virus Recognition.

Facing the escalating threat of viruses worldwide, the development of efficient sensor elements for rapid virus detection has never been more critical. Traditional point-of-care (POC) sensors struggle due to their reliance on fragile biological receptors and limited adaptability to viral strains. In this study, we introduce a nanosensor design for receptor-free virus recognitions using near-infrared (NIR) fluorescent single-walled carbon nanotubes (SWCNTs) functionalized with a poly(ethylene glycol) (PEG)-phospholipid (PEG-lipid) array.

Nanosensor Chemical Cytometry: Advances and Opportunities in Cellular Therapy and Precision Medicine.

With the definition of therapeutics now encompassing transplanted or engineered cells and their molecular products, there is a growing scientific necessity for analytics to understand this new category of drugs. This Perspective highlights the recent development of new measurement science on label-free single cell analysis, nanosensor chemical cytometry (NCC), and their potential for cellular therapeutics and precision medicine. NCC is based on microfluidics integrated with fluorescent nanosensor arrays utilizing the optical lensing effect of a single cell to real-time extract molecular properties and correlate them with physical attributes of single cells.

Physicochemical Profiling of Macrophage Heterogeneity Using Deep Learning Integrated Nanosensor Cytometry.

Label-free single-cell analytics have been developed for understanding the collective immune response mechanism of immune cells. However, it remains difficult to analyze the physicochemical properties of a single cell in high spatiotemporal resolution for an immune cell having dynamic morphological changes and significant molecular heterogeneities. It is deemed due to the absence of a sensitive molecular sensing construct and single-cell imaging analytic program.

Rapid and Reversible Sensing Performance of Hydrogen-Substituted Graphdiyne.

The design of new nanomaterials for rapid and reversible detection of molecules in existence is critical for real-world sensing applications. Current nanomaterial libraries such as carbon nanotubes, graphene, MoS, and MXene are fundamentally limited by their slow detection speed and small signals; thus, the atomic-level material design of molecular transport pathways and active binding sites must be accompanied. Herein, we fully explore the chemical and physical properties of a hydrogen-substituted graphdiyne (HsGDY) for its molecular sensing properties.

Top-Down Approaches for 10 nm-Scale Nanochannel: Toward Exceptional HS Detection.

Metal oxide semiconductors (MOS) have proven to be most powerful sensing materials to detect hydrogen sulfide (HS), achieving part per billion (ppb) level sensitivity and selectivity. However, there has not been a way of extending this approach to the top-down HS sensor fabrication process, completely limiting their commercial-level productions. In this study, we developed a top-down lithographic process of a 10 nm-scale SnO nanochannel for HS sensor production.