Transplantation Immunity. Contemporary Views.

"Transplantation immunity in Cyclosporin era" is a special chapter in science under name transplantation immunity. Nowadays, practically all the organs can be grafted: kidney, heart, lung, liver, pancreas both as organ, and as islet cells, bone marrow from relative and unrelative donors. The broad spectrum of grafted organs gave one more surprising peculiarity of transplantation immunity: it operates with different strength after transplantation of various organs.

Major Histocompatibility Complex.

At the 2nd Congress of Russian Immunologists, which is holding at the boundary not only two centuries, but and millennia, we had to present views, how the knowledge about major histocompatibility system has been changed (better to say has been progressed) for the brief historical period (50-60 years). 1. Having started from two, and then three component genetic HLA structure, the further studies gave image about multicomponent genetic composition of HLA, which is still not clarified up till now.

Interrelations between Immunogenetic Factors (HLA antigens) and Lymphocyte Subset Quantitative Rearrangements in Hodgkin's Disease Patients.

In this report we analyzed interrelations between cell quantity in lymphocyte subsets and lymphocyte immunogenetic (HLA) markers in 30 untreated patients with Hodgkin's disease (HD). We defined percentage and the absolute number of peripheral blood lymphocyte subsets expressing CD3, CD4, CD8, CD16, CD25 and CD72 markers for HD patients referring to their HLA phenotype (A, B, Cw loci and DRB1). HD patients had decreased absolute number of all the lymphocyte subsets.