Publications by authors named "Yuling Lin"

Traditional antimicrobial-susceptibility testing methodologies, including the isolation and culture of bacteria from urine samples and antibiotic-susceptibility test (AST), are expensive and time-consuming. Therefore, a rapid, user-friendly phenotypic AST is urgently needed to guide treatment strategies. Several novel phenotypic AST platforms based on the physiological characteristics of bacteria obtained directly from clinical urine samples have been proposed as promising methods as rapid AST and appropriate antibiotic treatments.

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The challenging ring-opening homopolymerization of α-ethylidene-δ-vinyl-δ-valerolactone (EVL), derived from CO and 1,3-butadiene, has aroused extensive attention in consideration of economic efficiency and functionalization potential. In the contribution, we achieve the first cationic ring-opening polymerization (CROP) of EVL through a carbenium-based mechanism, yielding well-defined cyclic polyester PEVL with a number-average molecular weight () up to 12.8 kg/mol and a low dispersity of 1.

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Background: Chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) impose a substantial economic burden globally. This systematic review summarised the evidence on the costs of COPD, including post-TB diseases in low- and middle-income countries.

Methods: A systematic review was conducted and studies published between 1 January 2013 and 28 March 2022 (the date of the search) were identified using various electronic databases without language restrictions.

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Lour. is an evergreen tree of the genus Longan in the Sapindaceae family, native to tropical and subtropical regions. Longan embryonic development is closely related to fruit set and fruit quality.

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: Recent evidence supports the protective role of metformin on kidney function in patients with type 2 diabetes mellitus. However, its potential to prevent new-onset chronic kidney disease (CKD) in patients with type 2 diabetes mellitus with normal renal function remains unclear. Therefore, this study aimed to investigate whether metformin could prevent the development of new-onset CKD in such patients.

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Atherosclerosis is the primary cause of cardiovascular and cerebrovascular diseases. However, current anti-atherosclerosis drugs have shown conflicting therapeutic outcomes, thereby spurring the search for novel and effective treatments. Recent research indicates the crucial involvement of oral and gastrointestinal microbiota in atherosclerosis.

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The dysfunction of the endothelial lining in lesion-prone areas of the arterial vasculature significantly contributes to the pathobiology of atherosclerotic cardiovascular disease. Recent studies suggested that UDP-glucose pyrophosphorylase 2 (UGP2) plays a role in cell proliferation and survival. This study investigates the anti-apoptotic and anti-atherogenic effects of UGP2 both in vitro and in vivo.

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Pigmentation in rice is due mainly to the accumulation of anthocyanins. Five color mutant lines, AZ1701, AZ1702, AZ1711, AZ1714, and AZ1715, derived from the sodium azide mutagenesis on the non-pigmented IR64 variety, were applied to study inheritance modes and genes for pigmentation. The mutant line AZ1711, when crossed with IR64, displays pigmentation in various tissues, exhibiting a 3:1 pigmented to non-pigmented ratio in the F progeny, indicating a single dominant locus controlling pigmentation.

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Article Synopsis
  • The study focuses on the role of MaMPK19 in enhancing cold resistance in bananas, using the inhibitor SB203580 to assess its impact on stress responses.
  • Results indicated that inhibiting MaMPK19 reduced the expression of cold resistance genes and weakened cold tolerance in banana plants.
  • The researchers also optimized genetic transformation methods for bananas, achieving notable regeneration and positive transformation rates, which may aid in future breeding efforts.
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Background: Atypical teratoid rhabdoid tumor (ATRT) is an aggressive brain tumor that mainly affects young children. Our recent study reported a promising therapeutic strategy to trigger DNA damage, impede homologous recombination repair, and induce apoptosis in ATRT cells by targeting ribonucleotide reductase regulatory subunit M2 (RRM2). COH29, an inhibitor of RRM2, effectively reduced tumor growth and prolonged survival in vivo.

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Engrams, which are cellular substrates of memory traces, have been identified in various brain areas, including the amygdala. While most identified engrams are composed of excitatory, glutamatergic neurons, GABAergic inhibitory engrams have been relatively overlooked. Here, we report the identification of an inhibitory engram in the central lateral amygdala (CeL), a key area for auditory fear conditioning.

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  • HCC-1 is a CC-type chemokine that influences cellular processes like calcium concentration, leukocyte activity, and enzyme release, and its role in atherosclerosis is not well understood.
  • The study assessed HCC-1 levels in patients with atherosclerosis using various analytical methods and created mice models to observe its effects on inflammation and plaque stability.
  • Results indicated that higher HCC-1 levels were linked to atherosclerosis severity, promoting inflammatory responses in cells, suggesting that HCC-1 may serve as a potential biomarker for diagnosing atherosclerosis.
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  • Glutamate decarboxylase (GAD) is crucial for GABA metabolism and influences plant growth, stress responses, and hormone interactions; this study focused on GAD expression during early somatic embryogenesis in longan.
  • Researchers identified 6 GAD genes in longan and found that they are closely related to those in dicot plants, with their promoters linked to hormone and stress responses.
  • RNA-Seq and qRT-PCR showed high expression of GAD genes in early embryogenic cultures, particularly after treatment with growth regulators; overexpressing DlGAD5 enhanced GAD activity, indicating its role in hormone signaling and longan development.
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Hua () rhizomes are rich in flavonoids and other secondary metabolites, exhibiting remarkable antioxidant, anti-tumor, and immunomodulatory effects. flavonoid-biosynthesis-related genes have been characterized already. However, a comprehensive overview of flavonoid biosynthesis pathways is still absent.

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  • Benzoxazinoids (BXs), derived from tryptophan, are important for plant processes like auxin metabolism, which is crucial for somatic embryogenesis (SE).
  • The study utilized various methods to explore the gene evolution and expression related to early SE in longan, discovering 27 candidate genes and their evolutionary patterns differ between monocots and dicots.
  • Results indicated that a specific compound, DIMBOA, enhances early SE by modulating gene expression and affecting auxin levels, particularly showing a rise in IAA content after treatment that later decreases.
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Background: Medulloblastomas (MBs) are one of the most common malignant brain tumor types in children. MB prognosis, despite improvement in recent years, still depends on clinical and biological risk factors. Metastasis is the leading cause of MB-related deaths, which highlights an unmet need for risk stratification and targeted therapy to improve clinical outcomes.

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Major zygotic genome activation (ZGA) occurs at the late 2-cell stage and involves the activation of thousands of genes, supporting early embryonic development. The reasons underlying the regulation of ZGA are not clear. Acetylation modifications of histone tails promote transcriptional activation, and the maternal deletion of H4K16ac leads to failure in ZGA.

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Ran GTPases play essential roles in plant growth and development. Our previous studies revealed the nuclear localization of DlRan3A and DlRan3B proteins and proposed their functional redundancy and distinction in somatic embryogenesis, hormone, and abiotic stress responses. To further explore the possible roles of and , gene expression analysis by qPCR showed that their transcripts were both more abundant in the early embryo and pulp in longan.

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Objectives: Low plasma folate levels have been reported in patients undergoing hemodialysis and peritoneal dialysis (PD) in clinical studies. However, folate transport has never been mentioned as a factor contributing to low plasma folate levels in patients undergoing PD. The peritoneal equilibrium test (PET) assesses the plasma creatinine level and glucose transport abilities.

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  • The study focuses on bZIP transcription factors in longan, a plant species crucial for growth and stress resistance, and identifies 51 members of this gene family through extensive bioinformatics.
  • It uses techniques like RNA-seq, ATAC-seq, and ChIP-seq to analyze how these bZIPs are regulated during somatic embryogenesis (SE), highlighting four members with significant changes in gene expression and chromatin accessibility.
  • The research indicates that specific bZIP members respond to various hormones, suggesting they play vital roles in hormonal pathways that influence early SE development in longan.
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Drought is the stressor with a significant adverse impact on the yield stability of tea plants. HD-ZIP III transcription factors (TFs) play important regulatory roles in plant growth, development, and stress responses. However, whether and how HD-ZIP III TFs are involved in drought response and tolerance in tea plants remains unclear.

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  • * The study involved genome-wide identification of a specific banana gene and analyzed its expression under various environmental stresses, linking these factors to different growth responses.
  • * Results showed that while temperature stresses decreased gene expression, osmotic stress had minimal impact, and treatments with growth regulators (GA and SL) resulted in varying responses in different parts of the plant, indicating potential insensitivity in certain dwarf banana varieties.
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The Spt-Ada-Gcn5-acetyltransferase (SAGA) is an ancillary transcription initiation complex which is highly conserved. The ADA1 (alteration/deficiency in activation 1, also called histone H2A functional interactor 1, HFI1) is a subunit in the core module of the SAGA protein complex. ADA1 plays an important role in plant growth and development as well as stress resistance.

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  • GATA transcription factors play a crucial role in regulating gene expression, contributing to the growth and stress resilience of plants, though the longan gene has not been previously explored.
  • This study identified and classified 22 longan GATA genes, revealing their chromosomal distribution, exon/intron structures, and expression patterns under various conditions, including hormonal treatments.
  • Findings demonstrated that certain GATA genes are upregulated during key developmental stages and in response to drought-related signals, highlighting their potential role in enhancing drought tolerance in longan plants.
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Article Synopsis
  • - The study focused on the B3 family transcription factors in longan plants, identifying 75 genes that are distributed across the plant's 15 chromosomes and categorized into four subgroups based on their protein similarities and functions.
  • - Bioinformatics analyses showed that these transcription factors exhibit specific expression patterns during early somatic embryogenesis (SE) and zygotic embryo development, and their expression can be influenced by different hormones and environmental conditions.
  • - Key findings indicate that certain B3 family members are localized in the nucleus and may play significant roles in hormone signaling pathways crucial for longan development processes.
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