Influencing Factors of Social Anxiety of Undergraduate Nursing Students Based on Random Forest Model: A Cross-Sectional Study.

Aim: Social anxiety is common among students, yet research specifically on undergraduate nursing students is scarce. Previous studies have identified various influencing factors but lack a clear ranking of their importance, making it challenging to implement effective intervention strategies with limited resources. This study aims to assess the level of social anxiety in undergraduate nursing students and rank the importance of its influencing factors, providing essential insights for developing efficient and targeted interventions.

The mediating role of aging attitudes between social isolation and self-neglect: a cross-sectional study of older adults living alone in rural China.

Background: Self-neglect is a significant global public health issue, compromising the health, safety, and well-being of older adults. Despite extensive research on the prevalence and risk factors of self-neglect, the underlying psychosocial mechanisms remain underexplored. Social isolation and aging attitudes have been identified as important correlates of self-neglect; however, the precise interplay between these variables, particularly the mediating role of aging attitudes, has yet to be fully examined in the context of rural older adults.

Twice target-recognition mediated exonuclease iii (Exo-iii)-Propelled cascade signal recycling MicroRNA detection system with improved accuracy.

Simple yet specific miRNA detection remains an enormous challenge due to its low abundance in samples and the high similarity among homologous miRNAs. Here, we propose a novel fluorescent approach for miRNA detection with greatly elevated accuracy by utilizing exonuclease-iii (Exo-iii) assisted twice target recognition. The proposed method involves a "Sensing probe" engineered with two loop sections to facilitate dual target miRNA recognition.

Predictive factors of stress response of nursing student repeaters under the background of abolishing the final supplementary examination in China.

Background: Academic pressure and frustration stimulation are significant stressors in college students, and response to the prolonged stimuli would cause adverse mental and physical outcomes. However, more is needed to know about the stress response and its predictors among undergraduate nursing students retaking failed course under the background of the abolition of the Final Supplementary Examination in China. This study aimed to investigate the stress response and its predictive factors of nursing student repeaters who are retaking at least one failed course.

Interventions to improve social network in older people with sensory impairment: a systematic review.

Background: Sensory impairment significantly reduces speech discrimination and perception ability, presenting a challenge to effective communication. It can lead to social withdrawal and a reduced social network which can lead to cognitive impairment, seriously affecting the quality of life of older people. However, it is unclear which intervention components are effective to improving social network in older people with sensory impairment.

Influencing factors of sense of responsibility among undergraduate nursing students: A cross-sectional study.

Background: Nursing students are critical in responding to public health emergencies like the COVID-19 pandemic. Their ability to fulfill their responsibilities is influenced by their sense of responsibility, which holds profound cultural significance, particularly in traditional Chinese culture. However, limited research has specifically explored the sense of responsibility among undergraduate nursing students in China and globally.

Fear of positive evaluation mediates the relationship between self-efficacy and fear of negative evaluation in nursing students: A cross-sectional study.

Background: Fear of evaluation (including the negative and positive ones) has been the focus of scholarly attention as one of the core components of social anxiety. However, most existing research has focused on participants with social anxiety. Previous research has suggested that self-efficacy and fear of positive evaluation are associated with fear of negative evaluation.

Perceived social support mediates loneliness and social isolation: A cross-sectional study of Chinese older adults relocated for poverty relief.

Objectives: This study aimed to examine the mediating effect of perceived social support in the relationship between loneliness and social isolation among Chinese older adults relocated for poverty relief.

Methods: We surveyed 128 older migrants from four resettlement areas in Guizhou Province, southwest China. A general information questionnaire, the Lubben Social Network Scale-6, the Perceived Social Support Rating Scale, and the Single Item Loneliness Scale were used in our study.

Fear of negative evaluation: A cross-sectional study among undergraduate nursing students.

Objective: To understand the current fear of negative evaluation among undergraduate nursing students and analyse the factors influencing it.

Methods: A general information questionnaire, the scale of fear of negative evaluation, and the fear of positive evaluation scale were used to survey 546 undergraduate nursing students at Guizhou Medical University, China.

Results: Undergraduate nursing students scored a total of (15.

Nonlinear relationship between early postnatal weight gain velocity and neurodevelopmental outcomes in very-low birth weight preterm infants: A secondary analysis based on a published prospective cohort study.

Background: Extrauterine growth restriction among the very-low birth weight preterm infants (VLBWPIs) is associated with poorer cognitive development outcome, while the rapid weight gain in infancy increases the long-term risk of obesity and noncommunicable disease among VLBWPIs. However, the results of research on the association between early postnatal growth velocity and neurodevelopmental outcomes in VLBWPIs are still limited and controversial.

Objective: We aimed to explore the association between the growth velocity in early postnatal and neurodevelopmental impairment (NDI) among VLBWPIs.

CircRNA circ_0005273 contributes to the cisplatin resistance of cervical cancer cells by sponging miR-133b.

Circular RNAs (circRNAs) have been found to play important roles in drug resistance of human neoplasms. The aim of this study was to explore the effect of circ_0005273 on cisplatin (DDP) resistance of cervical cancer (CC) cells and identify its underlying mechanism. The quantitative real-time polymerase chain reaction (qRT-PCR) was performed to analyse circ_0005273 and miR-133b expressions, and cell counting kit-8 (CCK-8), Hoechst 33258 staining and caspase-3 activity analysis were performed to evaluate cell proliferation and apoptosis.

Self-efficacy and negative silence in the classroom: The mediating role of fear of negative evaluation.

Background: Negative silence in the classroom is a usual passive behavior, which means students tend to keep silent and are unwilling to participate in the teaching interaction. It hinders the classroom teaching quality severely. Previous studies have shown both self-efficacy and fear of negative evaluation are related to silent behavior.

A BTB/POZ domain-containing protein negatively regulates plant immunity in Nicotiana benthamiana.

Plants have evolved immune systems to fight against pathogens. However, it is still largely unknown how the plant immunity is finely regulated. Here we identified a BTB/POZ domain-containing protein, namely NbBTB, which is predicted to be a member of the ubiquitin E3 ligase complex.

Characteristics, correlations and health risks of PCDD/Fs and heavy metals in surface soil near municipal solid waste incineration plants in Southwest China.

As primary anthropogenic emission source of toxic pollutants such as heavy metals and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), municipal solid waste (MSW) incineration has caused worldwide concern. However, a comprehensive analysis of the pollution characteristics and health risks of PCDD/Fs and heavy metals in soils around MSW incineration plants is lacking. In this study, 17 PCDD/Fs and 11 heavy metals in soil samples collected near MSW incineration plants in Sichuan province were investigated to evaluate their pollution characteristics and potential health risk.

Negative silence in the classroom: A cross-sectional study of undergraduate nursing students.

Objective: To investigate the concept of negative silent behavior of undergraduate nursing students and its influencing factors.

Methods: A cross sectional study was conducted by using convenience sampling, and 269 nursing students enrolled from August-September 2021 in a higher medical institution in Guizhou Province were selected for the study and surveyed using the general information questionnaire, the degree of negative classroom silence scale, and a questionnaire on the factors influencing negative classroom silence. Multiple linear regression was used to analyze the influencing factors of classroom negative silence among nursing students.

Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways.

Background: The Qilin pill (QLP) is a traditional Chinese compound prescription comprising 15 herbs that has demonstrated significant therapeutic effects on premature ovarian insufficiency (POI) in recent years. However, a pharmacological evaluation of QLP on ovarian function remains to be conducted, and the key mechanism of QLP treatment on POI is unclear.

Methods: Premature ovarian insufficiency rats were established by bilateral partial ovariectomy.

Establishment of an in vitro method of rabbit embryo toxicity with toxicokinetics study.

This report introduces a novel method, rabbit whole embryo culture (WEC) combined with toxicokinetics (TK), for toxicity testing. Rodent WEC has been extensively used for in vitro screening of developmental toxicity. To improve the reliability of in vitro data, it is important to consider TK and species specificity.

Hospice care self-efficacy among clinical medical staff working in the coronavirus disease 2019 (COVID-19) isolation wards of designated hospitals: a cross-sectional study.

Background: The COVID-19 pandemic has caused more than 462,417 deaths worldwide. A large number of patients with severe COVID-19 face death in hospital. Hospice care is truly a philosophy of care that delivers patient-centred care to the terminally ill and their families.

A Phytophthora capsici effector suppresses plant immunity via interaction with EDS1.

EDS1 (Enhanced Disease Susceptibility 1) plays a crucial role in both effector-triggered immunity activation and plant basal defence. However, whether pathogen effectors can target EDS1 or an EDS1-related pathway to manipulate immunity is rarely reported. In this study, we identified a Phytophthora capsici Avirulence Homolog (Avh) RxLR (Arg-any amino acid-Leu-Arg) effector PcAvh103 that interacts with EDS1.

Effect of maternal folic acid supplementation on prostatitis risk in the rat offspring.

Purpose: Folic acid (FA) intake has increased to high levels in many countries for the prevention of neural tube defects. However, the impact of excess FA intake, particularly before and during pregnancy, requires further investigation. Our aim was to investigate the effect of maternal folic acid supplementation on prostatitis risk in the rat offspring.

Effects of oral cimetidine on the reproductive system of male rats.

Cimetidine is widely used for the treatment of digestive tract ulcers, but it induces testis injury. To explore the mechanisms underlying cimetidine-induced toxicity towards the testis, the effects of oral cimetidine on the reproductive system of male rats were assessed. Cimetidine was orally administered to male rats at 20, 40 or 120 mg/kg/day for 9 weeks.

Bioinformatical analysis and prediction of Nicotiana benthamiana bHLH transcription factors in Phytophthora parasitica resistance.

The basic helix-loop-helix (bHLH) family, one of the largest transcription factor groups in plants, regulates many critical developmental processes. However, their functions in plant defense have not been extensively studied in Nicotiana benthamiana, an important model plant species for phytopathology. Here, we identified N.

Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I).

. This study was aimed to investigate the reproductive toxicity of Zishen Yutai Pill (ZYP) on fertility and early embryonic development in rats. .