Rapid Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Total and Free Testosterone in Human Serum and Its Application to Monitoring Biomarker Response of Elite Athletes.

Total testosterone (TT) and free testosterone (FT) are important biochemical markers for anabolism of the human body, and can also serve as early screening indicators for overtraining syndrome (OTS). Presently, there is no fast and reliable serum TT and FT determination method in the field of sport science that can meet the requirements of sports research. Thus, a rapid and accurate determination method for serum TT and FT to fill the gap is needed urgently in sports training.

Better Life's Essential 8 contributes to slowing the biological aging process: a cross-sectional study based on NHANES 2007-2010 data.

Objective: To investigate the relationship between Life's Essential 8 (LE8) and Phenotypic Age Acceleration (PhenoAgeAccel) in United States adults and to explore the impact of LE8 on phenotypic biological aging, thereby providing references for public health policies and health education.

Methods: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2010, this cross-sectional study analyzed 7,339 adults aged 20 and above. Comprehensive assessments of LE8, PhenoAgeAccel, and research covariates were achieved through the integration of Demographics Data, Dietary Data, Laboratory Data, and Questionnaire Data derived from NHANES.

Association between dietary and behavioral-based oxidative balance score and phenotypic age acceleration: a cross-sectional study of Americans.

Objectives: In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging.

Methods: Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.

Development and application of Chinese medical ontology for diabetes mellitus.

Objective: To develop a Chinese Diabetes Mellitus Ontology (CDMO) and explore methods for constructing high-quality Chinese biomedical ontologies.

Materials And Methods: We used various data sources, including Chinese clinical practice guidelines, expert consensus, literature, and hospital information system database schema, to build the CDMO. We combined top-down and bottom-up strategies and integrated text mining and cross-lingual ontology mapping.

Cognizant Fiber-Reinforced Polymer Composites Incorporating Seamlessly Integrated Sensing and Computing Circuitry.

Structural fiber-reinforced polymer (FRP) composite materials consisting of a polymer matrix reinforced with layers of high-strength fibers are used in numerous applications, including but not limited to spacecraft, vehicles, buildings, and bridges. Researchers in the past few decades have suggested the necessary integration of sensors (e.g.

Water Intake and Handgrip Strength in US Adults: A Cross-Sectional Study Based on NHANES 2011-2014 Data.

This study aimed to examine the relationship between daily total intake of water (DTIW) and handgrip strength (HGS) among US adults and to explore the impact of water intake on muscle function and health, providing a reference for public health policies and health education. Using the data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, a cross-sectional survey design was adopted to analyze 5427 adults (48.37% female and 51.

Automatic Tree Height Measurement Based on Three-Dimensional Reconstruction Using Smartphone.

Tree height is a crucial structural parameter in forest inventory as it provides a basis for evaluating stock volume and growth status. In recent years, close-range photogrammetry based on smartphone has attracted attention from researchers due to its low cost and non-destructive characteristics. However, such methods have specific requirements for camera angle and distance during shooting, and pre-shooting operations such as camera calibration and placement of calibration boards are necessary, which could be inconvenient to operate in complex natural environments.

Correction and removal of expression of concern: Natural steroid-based cationic copolymers cholesterol/diosgenin--PDMAEMAs and their pDNA nanoplexes: impact of steroid structures and hydrophobic/hydrophilic ratios on pDNA delivery.

[This corrects the article DOI: 10.1039/D1RA00223F.].

Fast and Secure Image Encryption Algorithm with Simultaneous Shuffling and Diffusion Based on a Time-Delayed Combinatorial Hyperchaos Map.

Adding time delay to nonlinear systems can significantly improve their performance, making it possible to construct image-encryption algorithms with higher security. In this paper, we propose a time-delayed nonlinear combinatorial hyperchaotic map (TD-NCHM) with a wide hyperchaotic interval. Based on TD-NCHM, we develop a fast and secure image-encryption algorithm that includes a plaintext-sensitive key-generation method and a simultaneous row-column shuffling-diffusion encryption process.

Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues.

Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) can visualize the spatial distribution characteristics of molecules in tissues in situ, in which the matrix plays a key role. In this paper, we propose a platinum nanomaterial pre-coated matrix, which can be prepared in bulk by sputtering platinum nanoparticles onto slides using an ion sputterer and then used for MALDI-MS analysis by placing tissue sections on the matrix. We used this matrix for MALDI-MS imaging analysis of corn kernels and germinated wheat sections, and the results show that triacylglycerides were mainly distributed in the embryo of corn kernels and germinated wheat, and sugars were mainly distributed in the endosperm, with the highest content of disaccharides.

Evolution of Thin-Film Wrinkle Patterns on a Soft Substrate: Direct Simulations and the Effects of the Deformation History.

Surface wrinkling instability in thin films attached to a compliant substrate is a well-recognized form of deformation under mechanical loading. The influence of the loading history on the formation of instability patterns has not been studied. In this work, the effects of the deformation history involving different loading sequences were investigated via comprehensive large-scale finite element simulations.

Natural steroid-based cationic copolymers cholesterol/diosgenin--PDMAEMAs and their pDNA nanoplexes: impact of steroid structures and hydrophobic/hydrophilic ratios on pDNA delivery.

Using natural-based lipids to construct biocompatible, controllable and efficient nanocarriers and elucidating their structure-function relationships, was regarded as an important area for creating sustainable biomaterials. Herein, we utilized two natural steroids: cholesterol and diosgenin (bearing different hydrophobic tails) as the building blocks, to synthesize a series of natural steroid-based cationic random copolymers PMA6Chol--PDMAEMA and PMA6Dios--PDMAEMA RAFT polymerization. The results demonstrated that the steroid--PDMAEMA copolymers could efficiently bind pDNA (N/P < 3.

Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening.

Hematopoietic progenitor kinase (HPK1) is a negative regulator of T-cell receptor and B-cell signaling, which has been recognized as a novel antitumor target for immunotherapy. In this work, Glide docking-based virtual screening and kinase inhibition assay were performed to identify novel HPK1 inhibitors. The kinase inhibition assay results demonstrated five compounds with IC values below 20 μM, and the most potent one (compound M074-2865) had an IC value of 2.

Highly compressible nanocellulose aerogels with a cellular structure for high-performance adsorption of Cu(II).

Cellulose-based aerogels have considerable potential for various application due to renewable, low cost, and high availability. However, mechanical robustness and functionalization remain major challenges. Here, we synthesized a compressible, recoverable cellulose nanofiber (CNF)/carboxymethyl cellulose (CMC)/branched polyethyleneimine (BPEI) aerogel via electrostatic-modulated interfacial covalent crosslinking and freeze-drying process.

Effective degradation of VOCs from wood by Fe chelate activated dual oxidant (HO-PS).

Wood is rich in extractives and volatile oils that emit unpleasant odors and some harmful volatile organic compounds (VOCs). Chemical oxidation technologies processes high efficiency on the destruction of aqueous organic components via oxidation by radicals, however, wood block treatment scenarios suffer from the low availability of radicals in aqueous conditions owing to the special structure of the wood blocks, limitations of mass transfer and the short life of free radicals. Herein, ethylenediaminetetraacetic acid (EDTA) is selected as a chelating agent to synthesize EDTA-Fe chelate, thus introducing Fe into the wood by vacuum impregnation.

Ultralight and shapeable nanocellulose/metal-organic framework aerogel with hierarchical cellular architecture for highly efficient adsorption of Cu(II) ions.

Water contamination by heavy metal pollutants is a global concern due to detrimental effects on the environment and human health. Regenerable, high-performance heavy metal sorbents are urgently demanded for improved water purification. Herein, we present an elegant strategy of interweaving metal-organic framework (MOF-808-ethylene diamine tetraacetic acid) and TEMPO-oxidized cellulose nanofibers (TCNF) to construct freeways in hybrid aerogels for rapid and efficient transport and capture of heavy metal ions.

Novel Bionic Soy Protein-Based Adhesive with Excellent Prepressing Adhesion, Flame Retardancy, and Mildew Resistance.

Soy protein (SP)-based adhesives can replace traditional aldehyde-based adhesives for the manufacturing of wood-based panels. However, developing a SP-based adhesive with excellent prepressing bonding strength, flame retardancy, and mildew resistance remains a challenge. Herein, an inorganic crystal cross-linked hybrid SP adhesive was developed inspired by the "secreting-hardening" process of the mussel adhesive protein and the organic-inorganic hybrid adhesive system of the oyster.

Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults.

Purpose: To compare the effects of 12-week high-intensity interval training (HIIT) and vigorous-intensity continuous training (VICT) on cognitive function, physical fitness, VOmax, serum neurotransmitters and neurotrophic factors in overweight and obese elderly individuals.

Methods: Twenty-nine physically inactive older adults (18 males and 11 females) with a mean age of 64.8 ± 3.

Enhancement of Removal of VOCs and Odors from Wood by Microwave-Activated Persulfate.

Since traditional methods for removing volatile organic compounds (VOCs) from wood consume large amounts of energy and generate environmental pollution, it is desired to develop a convenient and green treatment method. Oxidation by microwave-activated persulfate (MW-PS) is a promising alternative method that has been used to eliminate VOCs from wood. The penetration of microwave energy can destroy the wood pit membranes and increase VOC emissions.

A new two-dimensional all-sp carbon allotrope with an indirect band gap and superior carrier mobility.

The success of fascinating graphene has motivated much interest in exploiting new two-dimensional (2D) carbon allotropes with excellent electronic and mechanical properties such as graphdiyne and penta-graphene. However, there are only very few reported structures for stable 2D all-sp3 carbon allotropes. Here, we proposed a new 2D all-sp3 carbon allotrope, named as TTH-carbon.

Mineral Composition and Its Control on Nanopores of Marine-Continental Transitional Shale from the Ningwu Basin, North China.

There is a large difference between the sedimentary environment and maturity of organic matter between marine shale and marine-continental transitional shale. It is of great significance to discuss the effect of inorganicminerals on the pores for marine-continental transitional shale gas exploration. In this study, scanning electron microscopy (SEM), low temperature liquid nitrogen adsorption and Xray diffraction (XRD) were conducted on eight marine-continental transitional shale samples from the Ningwu Basin, Shanxi Province, China.

Metallic glass coating for improving diamond dicing performance.

This is the first report on the coating of diamond dicing blades with metallic glass (MG) coating to reduce chipping when used to cut Si, SiC, sapphire, and patterned sapphire substrates (PSS). The low coefficient-of-friction (CoF) of Zr-based MG-coated dicing blades was shown to reduce the number and size of chips, regardless of the target substrate. Overall, SiC, sapphire and PSS were most affected by chipping, due to the fact that higher cutting forces were needed for the higher hardness of SiC, sapphire and PSS.

Instabilities of Thin Films on a Compliant Substrate: Direct Numerical Simulations from Surface Wrinkling to Global Buckling.

For structures consisting of a thin film bonded to a compliant substrate, wrinkling of the thin film is commonly observed as a result of mechanical instability. Although this surface undulation may be an undesirable feature, the development of new functional devices has begun to take advantage of wrinkled surfaces. The wrinkled structure also serves to improve mechanical resilience of flexible devices by suppressing crack formation upon stretching and bending.