Prediction of T Stage of Rectal Cancer After Neoadjuvant Therapy by Multi-Parameter Magnetic Resonance Radiomics Based on Machine Learning Algorithms.

Introduction: Since the response of patients with rectal cancer (RC) to neoadjuvant therapy is highly variable, there is an urgent need to develop accurate methods to predict the post-treatment T (pT) stage. The purpose of this study was to evaluate the utility of multi-parametric MRI radiomics models and identify the most accurate machine learning (ML) algorithms for predicting pT stage of RC.

Method: This retrospective study analyzed pretreatment clinical features of 171 RC patients who underwent 3 T MRI prior to neoadjuvant therapy and subsequent total mesorectal excision.

Optical-fiber sensor for 17β-Estradiol-binding aptamer evaluation and specific detection of 17β-Estradiol in serum at physiological concentrations.

Methods for evaluation of immobilized-small molecule-binding aptamers are rare. In this study, taking the evaluation of 17β-Estradiol (E2) aptamers as an example, we first summarized the reported affinity and specificity results of 16 E2 aptamers, highlighting the issues of insufficient and inconsistent results and the lacking of evaluation of immobilized aptamers. We further exemplified the limited application scope of current affinity techniques by testing the two most widely-applied E2 aptamers, Kim76 and Alsa35, using the three label-free fluorescence assays and two nuclease protection assays.

Effectiveness and safety of acupuncture for carpal tunnel syndrome: An overview of systematic reviews and meta-analyses.

Background: Several systematic reviews (SRs) and meta-analyses (MAs) have explored the effectiveness and safety of acupuncture for Carpal Tunnel Syndrome (CTS), but findings are inconsistent and vary in quality. Therefore, this overview aims to evaluate these SRs and MAs critically, synthesizing existing evidence on acupuncture in treating CTS.

Methods: We searched 7 databases from their inception to April 25, 2024, using the keywords "acupuncture", "carpal tunnel syndrome", and "systematic review".

Long term Coptidis Rhizoma intake induce gastrointestinal emptying inhibition and colon barrier weaken via bitter taste receptors activation in mice.

Background: Coptidis Rhizoma, a classic bitter traditional Chinese medicine, can lead to digestive dysfunction when long-term use according to traditional experience. Bitter taste receptors have been found to regulate gastrointestinal smooth muscle contraction. Coptidis Rhizoma alkaloids are potential agonists for bitter taste receptors, but whether they can induce gastrointestinal dysfunction via bitter taste receptors is not clear.

Realizing Kirchhoff's superposition law of light-irradiated pure spin currents in paralleled graphene nanoribbons.

Light-irradiated pure spin current has been achieved via several methods. In this work, we aim to realize its superposition law by reducing the quantum interference effect between parallel circuits via first principles. As an example, a single-layer zigzag graphene nanoribbon (ZGNR) and a two-layer ZGNR constituted two-probe structures are chosen as our model.

Exploring the anti-inflammatory effects of acupuncture and Chinese herbal medicine targeting the miRNA-146a/IRAK1/JNK1 pathway in an environmental dry eye rat model.

Background: Dry eye syndrome has emerged as a subject of substantial significance in the field of ophthalmological research, prompting an exploration of therapeutic approaches.

Objective: This study investigates the anti-inflammatory effects of acupuncture and Chinese herbal medicine in an environmental dry eye (EDE) rat model, focusing on the intricate "miRNA-146a/IRAK1/JNK1" pathway.

Material And Methods: The experimental groups included Control, Model, 0.

Characterization and quantification of the phytochemical constituents and anti-inflammatory properties of .

The dry roots of (Sims) Kosterm have a long-standing history in traditional Chinese medicine, renowned for their ability to regulate vital energy, relieve pain, warm the kidney, and dissipate cold. Recently, has been approved as a new food resource. To gain insights into the bioactive phytochemicals in , an ultrahigh-performance liquid chromatography coupled with high-resolution electrospray ionization quadrupole orbitrap spectrometry method was developed to investigate the chemical profiles of the ethanol extract of .

Aspartame enhances the scavenging activity of mice to low-dose Escherichia coli infection via strengthening macrophage phagocytosis caused by sweet taste receptor activation.

Aspartame is the most common artificial sweetener and a famous sweet-taste receptor agonist. Macrophages are essential in the antibacterial system to maintain the stability of the intestinal environment. Recently, the sweet taste receptor has been found in macrophages.

The ZmCPK39-ZmDi19-ZmPR10 immune module regulates quantitative resistance to multiple foliar diseases in maize.

Gray leaf spot, northern leaf blight and southern leaf blight are three of the most destructive foliar diseases affecting maize (Zea mays L.). Here we identified a gene, ZmCPK39, that encodes a calcium-dependent protein kinase and negatively regulates quantitative resistance to these three diseases.

Burden of RSV among inpatients with lower respiratory tract infection under 5 years of age: A 10-year retrospective study in Southwest China from 2009 to 2019.

Objectives: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection (LRTI). However, few comprehensive descriptions of the disease burden, medical resource utilization (MRU), and costs of RSV are available for China. This study aimed to provide the basis for the development of RSV prevention strategies by analyzing the burden of RSV among inpatients with lower respiratory tract infection under 5 years of age.

The chromosome-level Elaeagnus mollis genome and transcriptomes provide insights into genome evolution, glycerolipid and vitamin E biosynthesis in seeds.

Elaeagnus mollis, which has seeds with high lipid and vitamin E contents, is a valuable woody oil plant with potential for utilization. Currently, the biosynthesis and regulation mechanism of glycerolipids and vitamin E are still unknown in E. mollis.

The maize ZmCPK39-ZmKnox2 module regulates plant height.

Unlabelled: Plant height is an important agronomic trait that affects high-density tolerance and lodging resistance. However, the regulators and their underlying molecular mechanisms controlling plant height in maize remain understudied. Here, we report that knockout mutants of the calcium-dependent protein kinase gene (-KO) exhibit dramatically reduced plant height, characterized by shorter internodes and a slight decrease in node numbers.

Application of linaclotide in bowel preparation for colonoscopy in patients with constipation: A prospective randomized controlled study.

Background And Aim: Colonoscopy plays a crucial role in the early diagnosis and treatment of colorectal cancer. Adequate bowel preparation is essential for clear visualization of the colonic mucosa and lesion detection. However, inadequate bowel preparation is common in patients with constipation, and there is no standardized preparation protocol for these patients.

A portable lateral flow distance-based paper sensor for drinking water hardness test.

Hardness is one of the basic parameters of water, and a high-level hardness of drinking water may be harmful to human health. Thus, it is very important to monitor drinking water hardness. In this work, a portable lateral flow distance-based paper sensor for the semi-quantitative detection of drinking water hardness is demonstrated.

Metformin enhances the therapeutic effects of extracellular vesicles derived from human periodontal ligament stem cells on periodontitis.

Metformin has shown outstanding anti-inflammatory and osteogenic abilities. Mesenchymal stem cell-derived extracellular vesicles (EVs) reveal promising therapeutic potency by carrying various biomolecules. This study explored the effects of metformin on the therapeutic potential of EVs derived from human periodontal ligament stem cells (PDLSCs) for periodontitis.

Expression pattern of Stlhcb gene family in potato and effects of overexpression of Stcp24 gene on potato photosynthesis.

Potato is one of the four staple food crops in the world. It has a wide range of cultivation, high yield, and high nutritional value. Enhancing the photosynthesis of potato is particularly important as it leads to an increase in the potato yield.

Role and mechanisms of autophagy, ferroptosis, and pyroptosis in sepsis-induced acute lung injury.

Sepsis-induced acute lung injury (ALI) is a major cause of death among patients with sepsis in intensive care units. By analyzing a model of sepsis-induced ALI using lipopolysaccharide (LPS) and cecal ligation and puncture (CLP), treatment methods and strategies to protect against ALI were discussed, which could provide an experimental basis for the clinical treatment of sepsis-induced ALI. Recent studies have found that an imbalance in autophagy, ferroptosis, and pyroptosis is a key mechanism that triggers sepsis-induced ALI, and regulating these death mechanisms can improve lung injuries caused by LPS or CLP.

Effects of jujube ( mill.) fruit extracts on oxidative stress: A systematic review and meta-analysis of rodent studies.

This study aimed to evaluate the effects of jujube ( Mill.) fruit extracts on oxidative stress levels in rodent models. Animal studies meeting the inclusion criteria were retrieved from PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and VIP Periodical Service Platform.

[Analysis of clinical characteristics and variant of NKX2-1 gene in a Chinese boy with Brain-Lung-Thyroid syndrome].

Objective: To carry out clinical and genetic analysis for a child featuring Brain-Lung-Thyroid syndrome (BLTS).

Methods: A child who had presented at the Children's Hospital Affiliated to Shandong University on May 27, 2022 was selected as the study subject. Clinical data was collected.

Development of Dry and Liquid Duplex Reagent Mix-Based Polymerase Chain Reaction Assays as Novel Tools for the Rapid and Easy Quantification of Bovine Leukemia Virus (BLV) Proviral Loads.

Bovine leukemia virus (BLV) is prevalent worldwide, causing serious problems in the cattle industry. The BLV proviral load (PVL) is a useful index for estimating disease progression and transmission risk. We previously developed a quantitative real-time PCR (qPCR) assay to measure the PVL using the coordination of common motif (CoCoMo) degenerate primers.