Erratum: Gene silencing NMII promotes axonal regeneration against contusive spinal cord injury in rats.

[This corrects the article on p. 11345 in vol. 10, PMID: 31966489.

Effects of Matrix Stiffness on the Morphology, Adhesion, Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells.

BMMSCs have drawn great interest in tissue engineering and regenerative medicine attributable to their multi-lineage differentiation capacity. Increasing evidence has shown that the mechanical stiffness of extracellular matrix is a critical determinant for stem cell behaviors. However, it remains unknown how matrix stiffness influences MSCs commitment with changes in cell morphology, adhesion, proliferation, self-renewal and differentiation.

Effective suppression of residual coherent phase error in a dual-polarization fiber optic gyroscope.

The impact of residual coherent phase error in a dual-polarization interferometric fiber optic gyroscope (IFOG) is investigated. Although it has been intuitively assumed that the coherence of a light source can be eliminated by a sufficient long fiber delay, the experiment and theory indicate that it still contributes a remarkable portion to long-term instability. After the residual coherent phase error is well handled, we demonstrate a dual-polarization IFOG with bias instability of 3.

PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Mutations of TP53 may reach 70% - 85% in HNSCC patients without human papillomavirus (HPV) infection. Recurrence rate remains particularly high for HNSCC patients with mutations in the TP53 gene although patients are responsive to surgery, irradiation, and chemotherapy early in the treatment.

Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours.

Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(d,l-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane.

Serum protein marker panel for predicting preeclampsia.

Background: Preeclampsia is a multi-system disorder in pregnancy which has no effective treatment. The diagnosis of preeclampsia is based on clinical presentation and routine laboratory tests.

Objective: This study aimed at identifying serum protein markers for diagnosis of preeclampsia and predicting its severe features.

Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1.

TP53 mutations frequently occur in head and neck squamous cell carcinoma (HNSCC) patients without human papillomavirus infection. The recurrence rate for these patients is distinctly high. It has been actively explored to identify agents that target TP53 mutations and restore wild-type (WT) TP53 activities in HNSCC.

Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy.

Circulating miRNAs are proposed as a biomarker of heart disease. This study evaluated whether circulating miRNAs could be used as a biomarker for childhood dilated cardiomyopathy (CDCM). A total of 28 participants were enrolled in a discovery set, including patients with CDCM (n = 16) and healthy children (n = 12).

Triple cell-responsive nanogels for delivery of drug into cancer cells.

In this report, biocompatible nanogels with multi cell-responsiveness (thermo-, pH- and reduction) were fabricated by in situ cross-linking of alginate (AG) using cystamine (Cys) as a cross-linker through an emulsion approach, in the presence of a thermosensitive polymer, poly(N-isopropylacrylamide) (PNIPAM). The AG/PNIPAM nanogels exhibited an abrupt swelling upon temperature increase from 37 to 25 °C under physiological conditions (497 ± 258 nm at 29 °C and 147 ± 48 nm at 37 °C). The nanogels were easily taken up by cancer cells at high temperature, where temperature variation could induce toxicity against cancer cells.

Separation of three polar compounds from Rheum tanguticum by high-speed countercurrent chromatography with an ethyl acetate/glacial acetic acid/water system.

The separation of polar compounds by high-speed countercurrent chromatography is still regarded as a challenge. In this study, an efficient strategy for the separation of three polar compounds from Rheum tanguticum has been successfully conducted by using high-speed countercurrent chromatography. X-5 macroporous resin chromatography was used for the fast enrichment of the target compounds.

Drug-mediation formation of nanohybrids for sequential therapeutic delivery in cancer cells.

In order to overcome the multidrug resistance (MDR) of tumor cells, it is very important to develop nanocarriers which can effectively load drugs while releasing them in a sequential way. Herein, nanohybrids with such properties have been fabricated by a first loading of one anticancer drug onto a silicate nanodisk (Laponite (LP), 25 nm in diameter and 0.92 nm in thickness) and a subsequent assembly with a pH sensitive poly(N-vinylpyrrolidone) (PVP) as a protective layer, followed by a loading of with another anticancer drug.

Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection.

Unlabelled: Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI.

Community structure of grassland ground-dwelling arthropods along increasing soil salinities.

Ground-dwelling arthropod communities are influenced by numerous biotic and abiotic factors. Little is known, however, about the relative importance of vegetation structure and abiotic environmental factors on the patterns of ground-dwelling arthropod community across a wide range of soil salinities. Here, a field survey was conducted to assess the driving forces controlling ground-dwelling arthropod community in the salinized grasslands in the Hexi Corridor, Gansu Province, China.

Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking.

Regeneration of skeletal muscle following injury is accompanied by transient inflammation. Here we show that complement is activated in skeletal muscle injury and plays a key role during regeneration. Genetic ablation of complement C3 or its inactivation with Cobra Venom Factor (CVF) result in impaired muscle regeneration following cardiotoxin-induced injury in mice.

Increased pollinator service and reduced pollen limitation in the fixed dune populations of a desert shrub.

Evaluations of restoration success usually focus on the structural aspects of ecosystems. Pollination, as an important functional aspect, is often overlooked. Here, the shifts in pollinator assemblage and pollen limitation in the desert shrub Caragana microphylla were examined along a restoration gradient in Horqin Sand Land, northern China.

Celastrol induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR.

Hepatocellular carcinoma (HCC) is one of the most serious and deadly diseases worldwide with limited options for effective treatment. Biomarker-based active compound targeting therapy may shed some light on novel drugs for HCC. The endoplasmic reticulum (ER) stress and unfolded protein response (UPR) play important roles in the regulation of cell fate and have become novel signaling targets for the development of anticancer drugs.

promotes type II collagen expression by targetting peroxisome proliferator-activated receptor-γ2 during rat articular chondrocyte differentiation.

MicroRNAs (miRNAs) play an essential role in articular cartilage development and growth. However, the exact mechanisms involved in this process remain unknown. In the present study, we investigated the biological functions of during hypertrophic differentiation of rat articular chondrocytes.

Bright and sensitive ratiometric fluorescent probe enabling endogenous FA imaging and mechanistic exploration of indirect oxidative damage due to FA in various living systems.

As a notorious toxin, formaldehyde (FA) poses an immense threat to human health. Aberrantly elevated FA levels lead to serious pathologies, including organ damage, neurodegeneration, and cancer. Unfortunately, current techniques limit FA imaging to general comparative studies, instead of a mechanistic exploration of its biological role, and this is presumably due to the lack of robust molecular tools for reporting FA in living systems.

Genome-wide DNA methylation drives human embryonic stem cell erythropoiesis by remodeling gene expression dynamics.

Aim: To investigate the role of DNA methylation during erythrocyte production by human embryonic stem cells (hESCs).

Methods: We employed an erythroid differentiation model from hESCs, and then tracked the genome-wide DNA methylation maps and gene expression patterns through an Infinium HumanMethylation450K BeadChip and an Ilumina Human HT-12 v4 Expression Beadchip, respectively.

Results: A negative correlation between DNA methylation and gene expression was substantially enriched during the later differentiation stage and was present in both the promoter and the gene body.

Compensation of thermal strain induced polarization nonreciprocity in dual-polarization fiber optic gyroscope.

Dual-polarization interferometric fiber optic gyroscope (IFOG) is a novel scheme in which the polarization nonreciprocal (PN) phase error of the two orthogonal polarizations can be optically compensated. In this work, we investigate the effective of PN phase error compensation under varying temperature. It is proved that, the thermally induced strain deforms the fiber, and results in perturbations on the birefringence and polarization cross coupling which degrades the IFOG's stability.

Gene silencing NMII promotes axonal regeneration against contusive spinal cord injury in rats.

There are drastic changes that occur in the impaired regions after spinal cord injury (SCI), however, improvement of the detrimental pathological process after injury is limited in the mammalian adult, which is due a large part to the failure of local axons to grow. Non-muscle myosin II (NMII) has been proved having essential role in the regulation of cytoskeletal structure and genetic silencing NMII markedly accelerates axon growth in vitro. Our purpose is to explore the association between phosphorylated NMII expression and axonal regeneration after SCI in rats and determine whether gene silencing NMII can improve the locomotor function in rats with SCI.

Impact of water level fluctuations on the development of phytoplankton in a large subtropical reservoir: implications for the management of cyanobacteria.

Lake water level fluctuations (WLF) are an important factor driving the selection and seasonal dynamics of phytoplankton and potentially toxigenic cyanobacteria. Nevertheless, the relative importance of environmental drivers connected to WLF may be completely different, depending on the typology and use of waterbodies, latitude and climatic regimes. In this study, we investigated the impact of WLF in a large subtropical reservoir in south-eastern China (Hongfeng Reservoir, Guizhou Province).

ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.

Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by polycystic ovaries, hyperandrogenism and anovulation. It is one of the main causes of infertility. RU486 is an antagonist of progesterone receptor, and most commonly used as a contraceptive.