Association of the C3953T (rs1143634) variant of the interleukin 1 beta gene with the features of a complicated course of COVID-19-associated pneumonia.

Background: The pro-inflammatory cytokine IL-1 plays an important role in severe COVID-19. A change in IL-1 production may be associated with a mutation in the IL1Β gene. Our study analyzed the impact of the IL1Β gene variants (rs1143634) on disease progression in patients with severe COVID-19 pneumonia, taking into account treatment strategies.

NOS3 (rs61722009) gene variants testing in prediction of COVID-19 pneumonia severity.

Background: There is a hypothesis that a sufficient level of endothelial nitric oxide synthase is important for reliable protection against COVID-19. Theoretical ideas about the NOS3 gene demonstrated that it can have an effect on links of the complications pathogenesis in COVID-associated pneumonia. We determined the goal - to investigate the association of the NOS3 gene variants with the occurrence of the disease and its clinical course in patients of the intensive care unit.

SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe COVID-19 pneumonia.

Background: Exploring the pathogenetic mechanisms behind severe lung damage in COVID-19 is crucial. In this study, we decided to focus on two molecular markers that affect surfactant metabolism and lung development: the surfactant protein B (SFTPB) and the glucocorticoid receptor (NR3C1) genes. The aim of our study was to determine the effect of SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants on the course of the disease in patients with COVID-19, and the treatment measures they required.

Modifying effects of , and genes on the development risk and the course of COVID-19. Pilot study.

Objectives: COVID-19 continues to range around the world and set morbidity and mortality antirecords. Determining the role of genetic factors in the development of COVID-19 may contribute to the understanding of the pathogenetic mechanisms that lead to the development of complications and fatalities in this disease. The aim of our study was to analyze the effect of (rs1800629), (rs1800795) and (rs731236 and rs1544410) genes variants on the development risk and the course of COVID-19 in intensive care patients.

ELECTROCARDIOGRAPHIC CHANGES IN NEWBORNS FROM MOTHERS WITH METABOLIC SYNDROME.

Objective: The aim: Analysis of electrocardiographic parameters in newborns from mothers with metabolic syndrome.

Patients And Methods: Materials and methods: We conducted a prospective cohort trial of 125 newborns, which included the study of their anthropometric, clinical and laboratory indicators and, in particular, ECG parameters. The main group consisted of 40 children, born from mothers with diagnosed metabolic syndrome, the comparison group included 2 subgroups: 28 term newborn and 57 preterm, from mothers without metabolic syndrome.

CLINICAL PREDICTION OF EARLY ONSET SEPSIS IN PRETERM NEONATES.

Objective: The aim of the study was to analyze and identify risk factors for the development of early onset sepsis in preterm neonates and to develop a clinical prognostic model.

Patients And Methods: Materials and methods: A retrospective cohort study included 152 newborns with birth weight from 1000 to 2500 g, who were treated in the neonatal intensive care units of medical institutions in the Poltava region. Among 152 children, 121 had clinical and laboratory symptoms of infection, which were regarded as manifestations of early onset sepsis, the rest of the children (n = 31) had no manifestations of infection.

Effect of enos gene polymorphism on the course of early onset bacterial infections in premature infants.

Objective: The aim of the study was to analyze the associations between 4a/4b polymorphism of the eNOS gene and impaired systemic hemodynamics in premature infants with early neonatal sepsis.

Patients And Methods: Materials and methods: We conducted a prospective cohort study, which included 120 premature babies with early neonatal sepsis, in 57 children the course of the disease was accompanied by arterial hypotension (AH) and in 61 children - not. In children of both groups, genotyping was performed to determine 4a/4b polymorphism of the eNOS gene.

Development of arterial hypotension in premature infants with early onset bacterial infections: tools of clinical predication.

Objective: Introduction: The safe thresholds of blood pressure in preterm neonates are still unclear. The aim of our study was to substantiate the diagnostic criteria for the syndrome of arterial hypotension (AH) and indications for the appointment of hemodynamic support in premature infants with early onset bacterial infections.

Patients And Methods: Materials and methods: A prospective cohort study was conducted.

[Predicting the occurrence of severe intraventricular hemorrhages and ways to prevent their development in preterm infants].

Objective: Introduction: Severe intraventricular hemorrhages (IVH) in preterm infants are one of the major public health problems, as they can cause neurological and cognitive impairment, as well as lethal outcomes. The aim: To prevent the development of IVH in preterm infants by developing an algorithm for identification of high risk infants and a bundle for the prediction and prevention of this pathology.

Patients And Methods: Materials and methods: A multicenter study (2013-2016) was conducted, which included 117 premature babies who were on treatment in 4 medical institutions in the Poltava region (Ukraine).