Mass Spectrometry-Based Proteomics Analysis Unveils PTPRS Inhibits Proliferation and Inflammatory Response of Keratinocytes in Psoriasis.

In this study, we used data-independent acquisition-mass spectrometry (DIA-MS) to analyze the serum proteome in psoriasis vulgaris (PsO). The serum proteomes of seven healthy controls and eight patients with PsO were analyzed using DIA-MS. Weighted gene co-expression network analysis was used to identify differentially expressed proteins (DEPs) that were closely related to PsO.

Predictive factors of atopic-like dermatitis induced by IL-17A inhibitors in patients with psoriasis: A 2-year follow-up study.

Background: Atopic-like dermatitis (ALD) is a common side effect of interleukin-17A (IL-17A) inhibitors.

Objective: To determine the prevalence, risk factors, outcomes and treatment of ALD in a cohort of psoriasis patients treated with IL-17A inhibitors.

Methods: This retrospective study included 226 psoriasis patients treated with an IL-17A inhibitor in our dermatology department between July 2020 and July 2022.

Protein Kinase CK2 Promotes Proliferation, Abnormal Differentiation, and Proinflammatory Cytokine Production of Keratinocytes via Regulation of STAT3 and Akt Pathways in Psoriasis.

Protein kinase CK2 is a constitutively active and ubiquitously expressed serine/threonine kinase that is closely associated with various types of cancers, autoimmune disorders, and inflammation. However, the role of CK2 in psoriasis remains unknown. Herein, the study indicated elevated expression of CK2 in skin lesions from patients with psoriasis and from psoriasis-like mice.

[Component Properties and Heavy Metal Accumulation Characteristics of Contaminated Rice Straw Biochar During Oxygen-controlled Pyrolysis].

Pyrolysis is an important technology to achieve the harmlessness and recycling of contaminated biomass. In this study, the effects of oxygen-controlled atmosphere on the component properties and heavy metal accumulation characteristics of contaminated rice straw biochar were studied. The results showed that low-oxygen pyrolysis could effectively produce biochar using contaminated rice straw and improve the stability of heavy metals in biochar.

Effect of Cd on Pyrolysis Velocity and Deoxygenation Characteristics of Rice Straw: Analogized with Cd-Impregnated Representative Biomass Components.

The pyrolysis characteristics of cadmium (Cd)-impregnated cellulose, hemicellulose, and lignin were studied to elucidate the pyrolysis velocity and deoxygenation characteristics of Cd-contaminated rice straw. The results show that Cd significantly affects the pyrolysis characteristics of a single biomass component. With a heating rate of 5 °C·min and a Cd loading of 5%, the initial pyrolysis temperature of cellulose and hemicellulose decreases while that of lignin increases.

Cleanup of arsenic, cadmium, and lead in the soil from a smelting site using N,N-bis(carboxymethyl)-L-glutamic acid combined with ascorbic acid: A lab-scale experiment.

Chemical washing has been carried out to remediate soil contaminated with heavy metals. In this study, the appropriate washing conditions for N,N-bis(carboxymethyl)-L-glutamic acid (GLDA) combined with ascorbic acid were determined to remove As, Cd, and Pb in the soil from the smelting site. The mechanism of heavy metal removal by the washing agent was also clarified.

The Downregulation of Placental Lumican Promotes the Progression of Preeclampsia.

Multiple pieces of evidence illustrate that impaired trophoblast function results in preeclampsia (PE), and migration/invasion of human trophoblast cells is stringently regulated by extracellular matrix (ECM) components. Many studies have indicated abnormal expressions of placental ECM components are associated with preeclampsia. However, the change and influence of lumican, a vital member of extracellular matrix (ECM) molecules, on trophoblast cells during preeclampsia remain unclear.

Steroid metabolome profiling of follicular fluid in normo- and hyperandrogenic women with polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is a heterogeneous disease defined by the presence of at least two of the following features: hyperandrogenism, oligoanovulation (OA), and polycystic ovarian morphology (PCOM). Hyperandrogenism is considered the cornerstone of PCOS. However, the most prevalent phenotype in Chinese women with PCOS is OA + PCOM [normo-androgenic PCOS (NA-PCOS)].

A neonate with tracheobronchial cobblestone mucosa presenting with acute severe hypercapnia.

Liu Y, Ly Li, Hu YL. A neonate with tracheobronchial cobblestone mucosa presenting with acute severe hypercapnia. Turk J Pediatr 2019; 61: 971-974.

In situ growth of copper rhodizonate complexes on reduced graphene oxide for high-performance organic lithium-ion batteries.

Novel copper rhodizonate (CPR) complexes are in situ grown on reduced graphene oxide (rGO) through a one-pot hydrothermal method. As anode materials for LIBs, the CPR/rGO composites show outstanding electrochemical lithium-storage performances, benefitting from both the insolubility of CPR in electrolytes and the effective assembly between CPR and rGO.

A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis.

To investigate the effect of basal hormone levels including follicle stimulating hormone (FSH) and estradiol (E) and age on the pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E, even though they had normal FSH.

Clinical practice of procalcitonin and hypersensitive c-reactive protein test in neonatal infection.

To study the clinical practice of procalcitonin and hypersensitive c-reactive protein test in neonatal infection. Two hundred cases of our hospital treatment confirmed infection early newborn children were selected from February 2014 to March 2015. According to the condition, the children were divided into four groups as follows: severe infection group, local infection group, non-infection group and healthy newborns group.

[Lactose intolerance in neonates with non-infectious diarrhea].

Objective: To investigate the development of lactose intolerance in neonates with non-infectious diarrhea and its association with diarrhea, and to evaluate the diagnostic values of fecal pH value and urine galactose determination for neonatal lactase deficiency.

Methods: Seventy hospitalized neonates who developed non-infectious diarrhea between October 2012 and June 2015 were enrolled as the diarrhea group, and 162 hospitalized neonates without non-infectious diarrhea were enrolled as the non-diarrhea group. Test paper was used to determine fecal pH value.

Report: Prevention infection of newborn nosocomial and distribution of multiple drug resistant organism of the medicinal.

2124 neonates were monitored from February 2013 to August 2014, among which 1119 were admitted from outpatient department (outpatient group), 782 were transferred from other departments (other department group), and 223 were from other hospitals (other hospital group). Through it we explore the distribution of multidrug resistant organism in neonates, which were admitted to the hospital through various ways, and therefore analyze the risk factors of nosocomial infection to avoid cross infection of multi drug resistant organism in neonatology department. The results showed that 105 strains of multi drug resistant bacteria were detected in the neonatal department.

The incidence of infants with rotavirus enteritis combined with lactose intolerance.

Unlabelled: This study was to research the incidence of infants with rotavirus enteritis combined with lactose intolerance and the clinical effect of low lactose milk powder for infantile rotavirus enteritis with lactose intolerance. The control groups were 126 cases of infants with diarrhea randomly collected from our hospital at the same period, which their rotavirus detection was negative. The observation group was 185 cases of infants with rotavirus, which was tested to be positive.

Diagnosis and clinical observation of lactose-free milk powder on treatment of neonatal diarrhea.

Neonatal lactose intolerance syndrome is a series of digestive system symptoms caused by the lack of lactase, and could not fully digest the lactose in breast milk or cow milk. Lactose is one of the disaccharides mainly existed in mammalian milk. Lactose content in breast milk is 7.

[Different expression of TNF-alpha in brain and peripheral organs after cerebral contusion of rats].

Objective: To compare the expression of tumor necrosis factor-alpha (TNF-alpha) between brain and peripheral organs after cerebral contusion in order to provide the scientific theoretical basis for forensic pathological diagnosis and wound age estimation.

Methods: Brain and peripheral organs including heart, liver, spleen, lung, kidney tissues of 45 SD rats after the cerebral contusion were obtained and TNF-alpha of these tissues were analyzed with immunohistochemistry methods.

Results: TNF-alpha was detected at 1 h in brain, reaching maximum at 6 h and 3 d after the cerebral contusion, and then decreased but still kept at high expression level at 7 d.

[Effect on PGF2alpha in plasma in primary dysmenorrhea treated with eye acupuncture].

Objective: To observe the clinical curative effect of primary dysmenorrhea and the content of prostaglandin F2alpha (PGF2alpha) in peripheral blood of menstrual periods treated with eye acupuncture therapy.

Methods: One hundred and ten cases of primary dysmenorrhea were randomly divided into an eye acupuncture group (60 cases) and a medication group (50 cases). In eye acupuncture group, low energizer area, liver area, kidney area, heart area and spleen area etc.

[Eye acupuncture for treatment of renal and ureteral colic].

Objective: To observe the therapeutic effect of eye acupuncture on renal and ureteral colic induced by ureterolith.

Methods: One hundred and eighty cases were randomly divided into an eye acupuncture group (n=90), a Morphine group (n=40) and a Bucinnazine group (n=50). The eye acupuncture group were treated with acupuncture at eye acupoints for killing pain, the Morphine group with intramuscular injection of Morphine and Atropine, and the Bucinnazine group with intramuscular injection of Bucinnazine and Atropine.

MR cholangiography and dynamic examination of duodenal fluid in the differential diagnosis between extrahepatic biliary atresia and infantile hepatitis syndrome.

In order to evaluate the value of magnetic resonance cholangiography (MRC) and dynamic examination of duodenal fluid in the differential diagnosis between extrahepatic biliary atresia (EHBA) and infantile hepatitis syndrome (IHS), 52 patients with infantile cholestatic jaundice were examined by MRC and duodenal fluid examination. Original interpretations were compared with clinical outcome. Calculated sensitivity of duodenal fluid examination in diagnosis of EHBA was 100%, and specificity was 91.