Publications by authors named "Yulia V Abalenikhina"
Article Synopsis
- - P-glycoprotein (Pgp) is an important protein that transports molecules out of cells, playing a key role in drug absorption, distribution, and resistance to chemotherapy.
- - The regulation of Pgp during oxidative stress is complex and involves transcription factors like Nrf2 and Nf-kB, which interact under various conditions influenced by the severity of the oxidative stress.
- - While oxidative stress typically increases Pgp expression, severe stress can actually reduce it due to amino acid oxidation; additionally, Pgp helps mitigate oxidative stress by eliminating harmful factors and participating in signaling pathways.
Organic anion transporting polypeptide 1B1 (OATP1B1) is an influx transporter protein of the SLC superfamily, expressed mainly in the liver and some tumor cells. The mechanisms of its regulation are being actively studied. In the present study, the effect of sex hormones (estradiol, progesterone and testosterone) on OATP1B1 expression in HepG2 cells was examined.
View Article and Find Full Text PDF2-Ethyl-6-methyl-3-hydroxypyridine succinate (EMHPS, Mexidol) is an original antioxidant and an anti-ischemic drug with the possibility of wide applications in the complex therapy of diseases, accompanied by the development of oxidative stress and ischemia; for example, ischemic stroke, chronic cerebral ischemia, and chronic heart failure. The use of EMHPS in the complex therapy of the above diseases may cause the development of drug-drug interactions, particularly pharmacokinetic interactions at the level of transporter proteins. In the present study, we evaluated the interaction of EMHPS with ABCB1 and SLCO1B1.
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- - The study investigated how nitric oxide (NO), donated by S-Nitrosoglutathione (GSNO), regulates the P-glycoprotein (Pgp) transporter in Caco-2 cells by varying concentrations and exposure times.
- - Short-term exposure (3 hours) to high GSNO (500 µM) decreased Pgp activity despite not affecting its overall amount, while longer exposure (24 hours) showed varying effects on Pgp amount and activity depending on GSNO concentration.
- - Low concentrations of GSNO led to increased Pgp levels via the NO-cGMP pathway, whereas higher concentrations resulted in reduced Pgp due to nitrosative stress influenced by Nrf2 and the constitutive and
P-Glycoprotein (P-gp) is one of the most clinically significant representatives of the ABC transporter superfamily due to its participation in the transport of biotic components and xenobiotics across the plasma membrane. It is known that various chemicals, environmental factors, and pathological processes can affect P-gp activity and expression. In this study, we investigated the role of P-gp in limiting the cell membrane permeability during oxidative stress.
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