Publications by authors named "Yulia Ragino"
Article Synopsis
- * Using PCR and pyrosequencing, researchers identified various mtDNA mutations, noting four proatherogenic (harmful) and three antiatherogenic (protective) mutations.
- * The study also revealed a geographic pattern in the distribution of certain mutations, highlighting a west-east gradient in specific mtDNA mutations associated with atherosclerosis.
Unlabelled: The research was aimed to study the associations of adipocytokines with the risk of cardiovascular events and to determine the threshold values of adipocytes for the prognosis of cardiovascular events in a young population.
Materials And Methods: The study is an epidemiological cohort study. The analysis included 1240 people aged 25-44 years.
Background: It is important to determine the influence of traditional risk factors on the development of type 2 diabetes mellitus (T2DM) in young adults. Goal of the research: To study the incidence of T2DM and factors that increase the risk of its occurrence during the observation of a cohort of young adults.
Materials And Methods: 1341 people aged 25-44 were included in the study from 2013 to 2017, of whom 622 were men (46.
Background: There are data supporting the idea that atherogenic dyslipidemia is a risk factor for CKD and reduced GFR. The aim was to evaluate the associations between adipocytokines and early renal dysfunction in young people with dyslipidemia.
Materials And Methods: A population study was conducted in IIPM-Branch of IC&G SB RAS, in 2013-2017.
The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25-44.
View Article and Find Full Text PDFObesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in men with coronary atherosclerosis on the background of abdominal obesity. The study involved 82 men aged 40-77 years with coronary atherosclerosis after endarterectomy from the coronary arteries.
View Article and Find Full Text PDFObjective: to study biomolecules associated with pathology in the respiratory system, in particular, with the development of chronic bronchitis in patients with abdominal obesity.
Materials And Methods: This is a pilot study. The main group consisted of 158 people with chronic bronchitis, divided into two subgroups: one with abdominal obesity, and the other without it.
The review is devoted to the analysis of literature data related to the role of proteomic studies in the study of atherosclerotic cardiovascular diseases. Diagnosis of patients with atherosclerotic plaques before clinical manifestations is an arduous task. The review presents the results of research on the new proteomic potential biomarkers of coronary heart disease, coronary atherosclerosis, acute coronary syndrome, myocardial infarction, carotid artery atherosclerosis.
View Article and Find Full Text PDFThis study investigated 12-year blood lipid trajectories and whether these trajectories are modified by smoking and lipid lowering treatment in older Russians. To do so, we analysed data on 9,218 Russian West-Siberian Caucasians aged 45-69 years at baseline participating in the international HAPIEE cohort study. Mixed-effect multilevel models were used to estimate individual level lipid trajectories across the baseline and two follow-up examinations (16,445 separate measurements over 12 years).
View Article and Find Full Text PDFThis work is aimed at studying the relationship of matrix metalloproteinases with calcification of the coronary arteries. The study included 78 people with coronary heart disease (CHD) and 36 without CHD. Blood and samples of coronary arteries obtained as a result of endarterectomy were examined.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to link mitochondrial DNA (mtDNA) mutations to carotid intima-media thickness (cIMT), which helps identify individuals at high risk for cardiovascular disease, using a sample of 468 subjects from Novosibirsk.
- - Several mtDNA mutations were found to positively or negatively correlate with cIMT, highlighting their potential role as predictors for atherosclerosis development, which could improve cardiovascular risk assessments.
- - The findings suggest key predictors for cIMT variability include age, blood pressure, cholesterol levels, and specific mtDNA mutations, potentially paving the way for gene therapy targeting atherosclerosis.
Objective: The aim was to study the blood cytokine/chemokine profile of 25-44-year-old people with early ischemic heart disease (IHD) comorbid with abdominal obesity (AO).
Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the above age group. A total of 1457 subjects, 804 females and 653 males, were analyzed.
Background: Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35-69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk.
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- * Results indicate that several heteroplasmic variants of mitochondrial DNA, identified as proatherogenic, are associated with cIMT in a sample of 251 participants from Russia and Kazakhstan.
- * Notably, variations in mitochondrial genome occurrence differ between Russian and Kazakh populations, and there is a negative correlation between the level of mitochondrial heteroplasmy (specifically m.13513G > A) and mean cIMT in both groups.