Publications by authors named "Yulia Meshkova"
Article Synopsis
- The research focuses on finding effective agents against coronaviruses, specifically by synthesizing thiazolo-thiophenes based on usnic acid to inhibit SARS-CoV-2's main protease.
- Certain modifications of the thiophene groups showed moderate antiviral activity, while others had no effect, with kinetic parameters evaluated for the most promising compound.
- The most active compound exhibited strong binding to the protease and effective antiviral activity against various SARS-CoV-2 strains, aligning molecular dynamics results with experimental findings.
Article Synopsis
- Type 2 diabetes mellitus (T2DM) is a widespread chronic disease, and despite existing treatments, their side effects necessitate the search for new diabetes drugs.
- This study tested two compounds, QS-528 and QS-619, on a diet-induced T2DM model in animals, finding that QS-619 effectively lowered blood sugar levels while QS-528 offered liver protection.
- The research revealed that both compounds activate the free fatty acid receptor-1 (FFAR1), potentially working as full agonists and enhancing insulin and glucose-dependent hormones in mice.
Article Synopsis
- FFAR1 agonists are being researched as potential treatments for type 2 diabetes due to their ability to lower blood sugar levels without causing hypoglycemia.
- The study involved synthesizing seven new compounds as structural analogs, modifying a previously developed FFA1 receptor agonist to investigate their effects on blood sugar regulation.
- The novel compounds demonstrated activation of FFAR1 and increased glucose uptake in liver cells without toxicity, with two specific compounds showing significant hypoglycemic effects in glucose tolerance tests on mice.
Article Synopsis
- In lab tests, shorter alkyl substitutes (C5 and C7) showed a stronger ability to stimulate glucose uptake in liver cells compared to longer ones (C10 and C12), while all derivatives performed better than the original berberine.
- In animal studies, the C12 derivative improved glucose metabolism in mice over four weeks, yet it also caused liver damage indicators by the end of the experiment.
Free fatty acid receptor-1 (FFAR1) is one of the possible therapeutic targets in the search for new hepatoprotective drugs. FFAR1 agonists were found to have hypolipidemic, antifibrotic, anti-inflammatory, antiproliferative and antioxidant effects in addition to hypoglycemic action. In this work, we conducted a study of the hepatoprotective effect of the compound QS-528 (previously discovered as an agonist of FFAR1) at doses of 60, 90, 120 and 150 mg/kg on carbon tetrachloride (CCl)-induced liver injury.
View Article and Find Full Text PDFSemisynthetic triterpenoid betulonic acid is of significant interest due to its biological activity and synthetic application. In this study, we report the synthesis of hybrid compounds, containing betulonic acid carboxamide and arylpyrimidine fragments. A total of 15 conjugates were prepared using the cyclocondensation reaction of new terpenoid alkynyl ketones with amidinium salts.
View Article and Find Full Text PDFIn , we consider a semigroup , , generated by a matrix elliptic second-order differential operator . Coefficients of are periodic, depend on , and oscillate rapidly as . Approximations for were obtained by Suslina (Funktsional Analiz i ego Prilozhen 38(4):86-90, 2004) and Suslina (Math Model Nat Phenom 5(4):390-447, 2010) via the spectral method and by Zhikov and Pastukhova (Russ J Math Phys 13(2):224-237, 2006) via the shift method.
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