Effect of and polymorphisms on the productivity, chemical composition, and fatty acid profile of meat from Simmental bulls.

Background And Aim: Enhancing the nutritional and biological value of meat obtained from young surplus replacement animals of dual-purpose breeds is a critical objective in the livestock industry. This study aimed to investigate the impact of (, ) and (, ) polymorphisms on the productivity, chemical composition, and fatty acid (FA) profile of meat from Simmental bulls.

Materials And Methods: A total of 26 Simmental bulls were genotyped for () and () polymorphisms and reared under the same fattening conditions.

Cytotoxicity of doxorubicin-conjugated poly[-(2-hydroxypropyl)methacrylamide]-modified γ-FeO nanoparticles towards human tumor cells.

Doxorubicin-conjugated magnetic nanoparticles containing hydrolyzable hydrazone bonds were developed using a non-toxic poly[-(2-hydroxypropyl)methacrylamide] (PHPMA) coating, which ensured good colloidal stability in aqueous media and limited internalization by the cells, however, enabled adhesion to the cell surface. While the neat PHPMA-coated particles proved to be non-toxic, doxorubicin-conjugated particles exhibited enhanced cytotoxicity in both drug-sensitive and drug-resistant tumor cells compared to free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery.