Unraveling the Molecular Mechanism of Selective Antimicrobial Activity of 2(5)-Furanone Derivative against .

causes various infectious diseases, from skin impetigo to life-threatening bacteremia and sepsis, thus appearing an important target for antimicrobial therapeutics. In turn, the rapid development of antibiotic resistance and biofilm formation makes it extremely robust against treatment. Here, we unravel the molecular mechanism of the antimicrobial activity of the recently unveiled consisting of three pharmacophores: chlorinated 2(5)-furanone, sulfone, and -menthol moieties.