Publications by authors named "Yulia Isaeva"
Light induced release of cisplatin from Pt(IV) prodrugs is a promising tool for precise spatiotemporal control over the antiproliferative activity of Pt-based chemotherapeutic drugs. A combination of light-controlled chemotherapy (PACT) and photodynamic therapy (PDT) in one molecule has the potential to overcome crucial drawbacks of both Pt-based chemotherapy and PDT via a synergetic effect. Herein we report green-light-activated Pt(IV) prodrug GreenPt with BODIPY-based photosentitizer in the axial position with an incredible high light response and singlet oxygen generation ability.
View Article and Find Full Text PDFOrganic semiconductor materials with a unique set of properties are very attractive for interfacing biological objects and can be used for noninvasive therapy or detection of biological signals. Here, we describe the synthesis and investigation of a novel series of organic push-pull conjugated molecules with the star-shaped architecture, consisting of triphenylamine as a branching electron donor core linked through the thiophene π-spacer to electron-withdrawing alkyl-dicyanovinyl groups. The molecules could form stable aqueous dispersions of nanoparticles (NPs) without the addition of any surfactants or amphiphilic polymer matrixes with the average size distribution varying from 40 to 120 nm and absorption spectra very similar to those of human eye retina pigments such as rods and green cones.
View Article and Find Full Text PDFArticle Synopsis
- Tuberculosis (TB) is a global health issue, especially with rising drug-resistant strains and connections to HIV, yet there's a lack of a centralized resource linking TB genome data with geographic and clinical information.
- The Genome-wide Mycobacterium tuberculosis Variation (GMTV) database compiles genome variations from M. tuberculosis strains in Russia, featuring data on drug resistance, clinical outcomes, and more, accessible through an online browser.
- GMTV helps track changes in TB strains across different regions, supports research on drug resistance and clinical effects, and enhances comparisons of M. tuberculosis genomes.
Article Synopsis
- The study focuses on the Mycobacterium tuberculosis (MTB) Beijing family, specifically the B0/W148 group found in Russia, which is known for being widespread, hypervirulent, and drug-resistant.
- Researchers sequenced four clinical isolates from this group and compared their genomes to the W-148 strain to identify significant genomic features.
- They discovered two large genomic inversions in the B0/W148 strains, suggesting that such rearrangements in MTB are more common than previously thought, highlighting the need for further research into these genetic changes.
Background: The steady rise in the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) requires rapid and reliable methods to identify resistant strains. The current molecular methods to detect MTB resistance to second-line drugs either do not cover an extended spectrum of mutations to be identified or are not easily implemented in clinical laboratories. A rapid molecular technique for the detection of resistance to second-line drugs in M.
View Article and Find Full Text PDFThe purpose of the present study was to analyse mutations in the gyrA and gyrB genes of Mycobacterium tuberculosis and define the possible correlation between these mutations and resistance to levofloxacin (LVX), moxifloxacin (MFX) and gatifloxacin (GAT), based on their MICs. One hundred and forty-two M. tuberculosis clinical isolates were collected from pulmonary tuberculosis patients in the Moscow region.
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