Publications by authors named "Yulia B Dorofeeva"
The presence of some species of helminths is associated with changes in host microbiota composition and diversity, which varies widely depending on the infecting helminth species and other factors. We conducted a prospective case-control study to evaluate the gut microbiota in children with Opisthorchis felineus infection (n=50) before and after anthelmintic treatment and in uninfected children (n=49) in the endemic region. A total of 99 children and adolescents aged between 7 and 18 years were enrolled to the study.
View Article and Find Full Text PDFArticle Synopsis
- There is a link between helminth (worm) infections and reduced allergic diseases, including bronchial asthma, often due to proteins released by the parasites that lower allergic reactions.
- The study examined how hemozoin (Hz), a byproduct from liver flukes, affects immune responses in both mouse and human dendritic cells (hDCs) from individuals with and without asthma, showing increased production of anti-inflammatory cytokines.
- Results indicated that while there were no differences in cellular maturation markers between hDCs from asthma patients and healthy controls, the exposure to Hz combined with lipopolysaccharide (LPS) significantly elevated levels of certain cytokines (IL-10 and IL-12β) in hDC