Comparative Genomics Reveals Evidence of the Genome Reduction and Metabolic Potentials of Isolated from Challenger Deep Sediment of the Mariana Trench.

Hadal zones account for the deepest 45% of oceanic depth range and play an important role in ocean biogeochemical cycles. As the least-explored aquatic habitat on earth, further investigation is still required to fully elucidate the microbial taxonomy, ecological significance, metabolic diversity, and adaptation in hadal environments. In this study, a novel strain Lsc_1132 was isolated from sediment of the Mariana Trench at 10,954 m in depth.

Genome-based reclassification of Chhetri . 2023 as a later heterotypic synonym of Gao . 2023.

DHUNG17 was compared with XHP0097 to examine the taxonomic relationship between the two type strains. The 16S rRNA gene sequence of DHUNG17 shared high similarity (99.9 %) to that of XHP0097.

Genome-based reclassification of (Rajasabapathy . 2016) Wirth . 2018 as a later heterotypic synonym of (Lai . 2011) Wirth . 2018.

VSW210 was compared with CK-I3-6 to examine the taxonomic relationship between the two type strains. In phylogenetic trees drawn using whole genome sequences and 16S rRNA gene sequences, VSW210 and CK-I3-6 clade together and showed a 99.6 % 16S rRNA sequence similarity.

Hydrangea-like MoS/carbon dots anode for high-performance sodium storage.

Owing to their quantum size, edge effects, and abundant surface functional groups, carbon dots (CDs) have attracted significant attention. In this study, chitin-derived carbon dots (CT-CDs) were prepared and used to synthesize MoS/CT-CDs. The abundant functional groups on the surface of the CT-CDs facilitated the orderly arrangement of MoS nanosheets, resulting in a hydrangea-like structure.

Genome-based reclassification of Hussain . 2016 as a later heterotypic synonym of Cha . 2014.

YIM F302 was compared with N5 to examine the taxonomic relationship between the two type strains. The 16S rRNA gene sequence of YIM F302 showed high similarity (99.9 %) to that of N5.

Baricitinib Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice by Inhibiting TGF-β1 Signaling Pathway.

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease with unknown etiology, high mortality and limited treatment options. It is characterized by myofibroblast proliferation and extensive deposition of extracellular matrix (ECM), which will lead to fibrous proliferation and the destruction of lung structure. Transforming growth factor-β1 (TGF-β1) is widely recognized as a central pathway of pulmonary fibrosis, and the suppression of TGF-β1 or the TGF-β1-regulated signaling pathway may thus offer potential antifibrotic therapies.

sp. nov., a marine bacterium isolated from deep seawater of the Mariana Trench.

A Gram-stain-negative, non-motile and rod-shaped bacterium, designated as strain W52, was isolated from deep seawater of the Mariana Trench and characterized phylogenetically and phenotypically. The strain could grow at 10-47 °C (optimum 32 °C), at pH 5.0-8.

Zanubrutinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal interstitial lung disease with high mortality and limited treatment. Only two drugs are currently approved for the treatment of IPF, but both have limitations and neither drug could prolong survival time of patients. The etiology of IPF is unclear, but there is growing evidence that B cells and B cell receptor signaling play important roles in the pathogenesis of IPF.

Pseudomonas marianensis sp. nov., a marine bacterium isolated from deep-sea sediments of the Mariana Trench.

A novel marine Gram-stain-negative, aerobic, rod-shaped bacterium, designated as strain PS1, was isolated from the deep-sea sediments of the Mariana Trench and characterized phylogenetically and phenotypically. Bacterial optimal growth occurred at 35 °C (ranging 10-45 °C), pH 6 (ranging pH 5-10) and with 11% (w/v) NaCl (ranging 0-17%). The 16S rRNA gene sequence similarity results revealed that strain PS1 was most closely related to Pseudomonas stutzeri ATCC 17588, Pseudomonas nitrititolerans GL14, Pseudomonas zhaodongensis NEAU-ST5-21, Pseudomonas xanthomarina DSM 18231 and Pseudomonas kunmingensis HL22-2 with 98.

Complete genome sequence of a multiple-stress-tolerant bacterium NBT06E8 isolated from a deep-sea sediment sample of the New Britain Trench.

Unlabelled: NBT06E8 is a Gram-stain-negative, moderately halophilic, piezotolerant, HO and heavy metal-resistant bacterium, isolated from a deep-sea sediment sample collected from the New Britain Trench at depth of 8900 m. Growth of the strain was observed at 4-45 °C (optimum 30 °C), at pH 5-11 (optimum 8-9) and in 0.5-21% (w/v) NaCl (optimum 3-7%).

Zanubrutinib ameliorates lipopolysaccharide-induced acute lung injury via regulating macrophage polarization.

Acute lung injury (ALI) is a disease characterized by pulmonary diffusion dysfunction and its exacerbation stage is acute respiratory distress syndrome (ARDS), which may develop to multiple organ failure and seriously threatens human health. ALI has high mortality rates and few effective treatments, thus effective protection measures for ALI are becoming increasingly important. Macrophages play a key regulatory role in the pathogenesis of ALI, and the degree of macrophage polarization is closely related to the severity and prognosis of ALI.

sp. nov., isolated from a tidal flat sediment of the East China Sea.

A Gram-stain-negative bacterial strain, designated as E165, was isolated from a tidal flat sediment of the East China Sea. Strain E165 grew optimally at pH 6, at 32 °C and with 1-2 % (w/v) NaCl. The 16S rRNA gene sequence similarity results revealed that strain E165 was most closely related to IVIA-Po-145, CK13, IVIA-Po-155, HDW-15, 46-16, B20-1 and DSL-35 with values of 97.

Novel Chloroflexi genomes from the deepest ocean reveal metabolic strategies for the adaptation to deep-sea habitats.

Background: The deep sea harbors the majority of the microbial biomass in the ocean and is a key site for organic matter (OM) remineralization and storage in the biosphere. Microbial metabolism in the deep ocean is greatly controlled by the generally depleted but periodically fluctuating supply of OM. Currently, little is known about metabolic potentials of dominant deep-sea microbes to cope with the variable OM inputs, especially for those living in the hadal trenches-the deepest part of the ocean.

Isorhamnetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting mTOR signaling pathway.

Acute Lung Injury (ALI) is an acute hypoxic respiratory insufficiency caused by various traumatic factors, manifested as progressive hypoxemia and respiratory distress, and lung imaging shows a heterogeneous osmotic outbreak. Isorhamnetin (ISO) is a flavonoid compound isolated and purified from medicinal plants, such as L. and Ginkgo, and has multiple pharmacological functions, such as anti-tumor, anti-myocardial hypoxia, and cardiovascular protection.

Cabozantinib ameliorates lipopolysaccharide-induced lung inflammation and bleomycin--induced early pulmonary fibrosis in mice.

The lung, as the primary organ for gas exchange in mammals, is the main target organ for many pathogens and allergens, which may cause acute lung injury. A certain proportion of acute lung injury may progress into irreversible pulmonary fibrosis. Both acute lung injury and pulmonary fibrosis have high mortality rates and few effective treatments.

He . 2018 is a later heterotypic synonym of Park . 2018.

L53 was compared with MM-14 to examine the taxonomic relationship between the two type strains. The 16S rRNA gene sequence of L53 had complete similarity (100.0%) to that of MM-14.

Kim . 2020 is a later heterotypic synonym of Yamamura . 2019.

KZ-21 was compared with THG-SMD2.3 to examine the taxonomic relationship between the two type strains. The 16S rRNA gene sequence of KZ-21 shared complete similarity (100.

Qu . 2020 is a later heterotypic synonym of Klykleung . 2020.

WYY166 was compared with PA1-10 to examine the taxonomic relationship between the two type strains. The 16S rRNA gene sequence of WYY166 had high similarity (99.9 %) to that of PA1-10.

Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis.

Background: COVID-19 (Coronavirus Disease-2019) has spread widely around the world and impacted human health for millions. The lack of effective targeted drugs and vaccines forces scientific world to search for new effective antiviral therapeutic drugs. It has reported that flavonoids have potential inhibitory activity on SARS-CoV-2 M and anti-inflammatory properties.

Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by epithelial cell damage, fibroblast activation, and collagen deposition. IPF has high mortality and limited therapies, which urgently needs to develop safe and effective therapeutic drugs. Bergenin, a compound derived from a variety of medicinal plants, has demonstrated multiple pharmacological activities including anti-inflammatory and anti-tumor, also acts as a traditional Chinese medicine to treat chronic bronchitis, but its effect on the pulmonary fibrosis is unknown.

Community structure and activity potentials of archaeal communities in hadal sediments of the Mariana and Mussau trenches.

Unlabelled: Hadal trenches are the least explored marine habitat on earth. Archaea has been shown to be the dominant group in trench sediments. However, the activity potentials and detailed diversity of these communities as well as their inter-trench variations are still not known.

Revealing the full biosphere structure and versatile metabolic functions in the deepest ocean sediment of the Challenger Deep.

Background: The full biosphere structure and functional exploration of the microbial communities of the Challenger Deep of the Mariana Trench, the deepest known hadal zone on Earth, lag far behind that of other marine realms.

Results: We adopt a deep metagenomics approach to investigate the microbiome in the sediment of Challenger Deep, Mariana Trench. We construct 178 metagenome-assembled genomes (MAGs) representing 26 phyla, 16 of which are reported from hadal sediment for the first time.

Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway.

Idiopathic pulmonary fibrosis is a progressive lung disease with high mortality and limited therapy that is characterized by epithelial cell damage and fibroblast activation. Ellagic acid is a natural polyphenol compound widely found in fruits and nuts that has multiple pharmacological activities. In this study, we explored the potential effects and mechanisms of Ellagic acid on pulmonary fibrosis and .