Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections.

Background: Tumor-infiltrating lymphocytes (TILs) constitute a prognostic factor in hepatocellular carcinoma (HCC). However, different methods of assessing TILs have various pre-analytical, analytical, and post-analytical challenges. The evaluation of TILs in hematoxylin and eosin (H&E)-stained tumor sections proposed by the International Immuno-Oncology Biomarker Working Group was demonstrated to be a reproducible, affordable and easily applied method in many tumors.

Caspase Recruitment Domain Containing Protein 9 Suppresses Non-Small Cell Lung Cancer Proliferation and Invasion via Inhibiting MAPK/p38 Pathway.

Purpose: Caspase recruitment domain containing protein 9 (CARD9) has been demonstrated to be a pro-tumor factor in various cancers. However, our previous study found a significant decrease of CARD9 in malignant pleural effusion compared with benign pleural effusion. So we investigated the role of CARD9 in non-small cell lung cancer (NSCLC) and its working mechanism.

Self-activation of biochar from furfural residues by recycled pyrolysis gas.

Biochar samples with controllable specific surface area and mesopore ratio were self-activated from furfural residues by recycled pyrolysis gas. The objective of this study was to develop a new cyclic utilization method for the gas produced by pyrolysis. The influences of preparation parameters on the resulting biochar were studied by varying the pyrolysis-gas flow rate, activation time and temperature.

Hepatitis C virus infection and risk of thyroid cancer: A systematic review and meta-analysis.

Purpose: Several epidemiological studies investigated the relationship between hepatitis C virus (HCV) infection and risk of thyroid cancer, but the results were not consistent. A systematic review and meta-analysis was conducted to assess the impact of HCV infection on thyroid cancer risk.

Methods: The literature was searched up to March 15, 2016 for case-control or cohort studies on the association between HCV infection and thyroid cancer risk.

Low-dose volume perfusion computed tomography (VPCT) for diagnosis of solitary pulmonary nodules.

Objective: To characterize solitary pulmonary nodules (SPN) in terms of perfusion parameters using low-dose volume perfusion computed tomography (VPCT) and two different calculation methods, compare their results, look for interobserver agreement of measurements and investigate the feasibility of low-dose VPCT.

Materials And Methods: This study was approved by the local Institutional Review Board and all patients provided written informed consent. Seventy-one patients (mean age 60.

The recycling of incinerated sewage sludge ash as a raw material for CaO-Al2O3-SiO2-P2O5 glass-ceramic production.

In this paper, the recycling of incinerated sewage sludge ash (ISSA) into glass-ceramic materials by a two-stage sintering cycle of nucleation stage and crystallization stage without any pressure and binder is presented. The parent glasses were subjected to the following nucleation/crystallization temperature and time level: (A) 790°C, 1.0 h/870°C, 1.

[Immunohistochemical classification and prognosis of diffuse large B-cell lymphoma in China].

Objective: To study the immunohistochemical classification and prognosis of diffuse large B-cell lymphoma (DLBCL).

Methods: A total of 148 cases of DLBCL were classified into germinal center B-cell-like (GCB) and non-GCB/activated B-cell-like (ABC) subtypes by Hans, Choi and Tally immunohistochemical stain algorithms. The clinical features and survival data of GCB and non-GCB/ABC subtypes were compared.

Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients.

Objective: To evaluate the correlation between programmed death-ligand 1 (PD-L1) expression in primary lung cancer cells, tumor associated macrophages (TAM) and patients' clinicopathological characteristics.

Methods: From 2008 to 2010, 208 non-small cell lung cancer patients who underwent surgery or CT-guided biopsy were recruited from Huadong Hospital, Fudan University. Immunohistochemistry staining was performed to evaluate the PD-L1 expression in both primary lung cancer cells and CD68 positive TAM.

Expression of the adipocytokine resistin and its association with the clinicopathological features and prognosis of pancreatic ductal adenocarcinoma.

Fat tissue is viewed as an active endocrine organ that secretes a variety of bioactive substances. Resistin, an adipocyte-secreted factor, is thought to be closely related to obesity, insulin resistance and inflammation, the three most significant risk factors for the progression of pancreatic cancer. However, the association between resistin and pancreatic cancer is still unknown.

Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in non-small cell lung cancer and its significance.

Expression of monocyte chemoattractant protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) and its significance has been demonstrated in some cancer cells in recent clinical studies. However, the role of tumor MCP-1 and CCR2 expression in non-small cell lung cancer (NSCLC) remains unknown. The aim of the present study was to investigate the prognostic significance of MCP-1 and CCR2 expression in NSCLC cells.

[Cytogenetic profiles of follicular lymphoma].

Objective: To study the cytogenetic profiles of follicular lymphoma (FL) in Chinese patients.

Methods: Conventional karyotype in 57 FL patients from Shanghai area was analyzed. Fluorescence in-situ hybridization (FISH) for t(14;18) and Bcl-6 and IgH gene rearrangement was performed in these cases.

[Urothelial hyperplastic lesion with endophytic growth pattern: a clinicopathologic study].

Objective: To study the clinicopathologic features of urothelial hyperplastic lesion with an endophytic growth pattern and the role of immunohistochemistry and multitargeted fluorescence in situ hybridization (FISH) in the differential diagnosis.

Methods: Forty-one cases of urothelial lesions exhibiting endophytic growth patterns were reviewed and reclassified as inverted papilloma, urothelial carcinoma with an endophytic growth pattern, and florid von Brunn nest. The gains of chromosomes 3, 7, and 17 and loss of 9p21 was detected by FISH, and performed immunohistochemical staining for CK20, p53, and Ki-67.

[Value of spiral CT in diagnosis of cystic renal cell carcinoma].

Objective: To investigate the image features and the diagnostic value of spiral CT for cystic renal cell carcinoma.

Methods: The clinical data and CT manifestations of 17 operated and pathologically proven cystic renal cell carcinoma were retrospectively analyzed. There were 12 males and 5 females with an average age of 47.