Discovery of novel biaryl urea derivatives against IL-1β release with low toxicity based on NEK7 inhibitor.

Aberrant activation of NLRP3 inflammasome is involved in various inflammatory diseases, making it a promising target for therapeutic intervention. NEK7, a member of the NIMA-related kinase (NEK) family, functions as a key NLRP3-binding protein and plays a crucial role in the regulation of NLRP3 inflammasome assembly and activation. Thus, disrupting NLRP3-NEK7 interactions by targeting NEK7 could be a promising strategy to inhibit the activation of NLRP3 inflammasome.

High-performance adsorption of methylene blue using novel bio-adsorbent based on sargassum fusiforme.

Large specific surface area obtained by pyrolyzed biomass is considered as a vital factor in improving the dye adsorption performance. However, pyrolysis would cause the inevitable destruction of the surface functional groups of biomass. Herein, a biomass adsorbent based on sargassum fusiforme without pyrolysis was employed for the removal of methylene blue (MB).

Surgical Procedures of the Correction of Severe Static Glabellar Lines by Utilizing Resection with Free Dermal Fat Grafting (FDFG).

Background: Botulinum toxin alone is unable to sufficiently reduce the muscle in cases of severe static glabellar lines due to the folded skin and dermal breakdown that frequently accompany these conditions. Augmentation of the soft tissue and removal of folded skin at the same time is the final solution. To simultaneously resolve interbrow skin laxity and replenish tissue volume, we present for the first time the method of glabellar lines excision combined with FDFG.

Enhanced fatty acid storage combined with the multi-factor optimization of fermentation for high-level production of docosahexaenoic acid in Schizochytrium sp.

Schizochytrium sp. hasreceived much attention for itsability to synthesize and accumulate high-level docosahexaenoic acid (DHA), which can reach nearly 40 % of total fatty acids. In this study, the titer of DHA in Schizochytrium sp.

Identification of lipid synthesis genes in Schizochytrium sp. and their application in improving eicosapentaenoic acid synthesis in Yarrowia lipolytica.

Background: Eicosapentaenoic acid (EPA) is widely used in the functional food and nutraceutical industries due to its important benefits to human health. Oleaginous microorganisms are considered a promising alternative resource for the production of EPA lipids. However, the storage of EPA in triglyceride (TG) becomes a key factor limiting its level.

Application of Adaptive Laboratory Evolution in Lipid and Terpenoid Production in Yeast and Microalgae.

Due to the complexity of metabolic and regulatory networks in microorganisms, it is difficult to obtain robust phenotypes through artificial rational design and genetic perturbation. Adaptive laboratory evolution (ALE) engineering plays an important role in the construction of stable microbial cell factories by simulating the natural evolution process and rapidly obtaining strains with stable traits through screening. This review summarizes the application of ALE technology in microbial breeding, describes the commonly used methods for ALE, and highlights the important applications of ALE technology in the production of lipids and terpenoids in yeast and microalgae.

Function of the Polyketide Synthase Domains of sp. on Fatty Acid Synthesis in .

It is well known that polyunsaturated fatty acids (PUFAs) in sp. are mainly synthesized via the polyketide synthase (PKS) pathway. However, the specific mechanism of PKS in fatty acid synthesis is still unclear.

Progress of metabolic engineering for the production of eicosapentaenoic acid.

Eicosapentaenoic Acid (EPA) is an essential ω-3 polyunsaturated fatty acid for human health. Currently, high-quality EPA production is largely dependent on the extraction of fish oil, but this unsustainable approach cannot meet its rising market demand. Biotechnological approaches for EPA production from microorganisms have received increasing attention due to their suitability for large-scale production and independence of the seasonal or climate restrictions.

The application value of informatization-based extended nursing care on discharged children with leukemia.

Objectives: This study explored and analyzed the application value of informatization-based extended care on children discharged with leukemia.

Methods: 109 children receiving chemotherapy for acute leukemia in our hospital from January 2018 to January 2020 were selected as research subjects. The children were divided into the control group (n=53) and the observation group (n=56) on the basis of admission time point.

Recent advances in biotechnological production of polyunsaturated fatty acids by .

Owing to the important physiological functions, polyunsaturated fatty acids (PUFAs) play a vital role in protecting human health, such as preventing cancer, cardiovascular disease, and diabetes. Specifically, has been identified as the most popular non-conventional oleaginous yeast, which can accumulate the abundant intracellular lipids, indicating that has great potential as an industrial host for production of PUFAs. Notably, some novel engineering strategies have been applied to endow and improve the abilities of to synthesize PUFAs, including construction and optimization of PUFAs biosynthetic pathways, improvement of preucrsors acetyl-coA and NADPH supply, inhibition of competing pathways, knockout of β-oxidation pathways, regulation of oxidative stress defense pathways, and regulation of genes involved in upstream lipid metabolism.

Effect of Pennisetum giganteum z.x.lin mixed nitrogen-fixing bacterial fertilizer on the growth, quality, soil fertility and bacterial community of pakchoi (Brassica chinensis L.).

Biofertilizer plays a significant role in crop cultivation that had reduced its inorganic fertilizer use. The effects of inorganic fertilizer reduction combined with Pennisetum giganteum z.x.

Protective effects of tetramethylpyrazine analogue Z-11 on cerebral ischemia reperfusion injury.

The aim of our study was to investigate the effects of a new synthetic compound (E) -1- (E) -1- (2- hydroxy -5- chlorophenyl) -3- (3, 5, 6- three methyl pyrazine -2- based) -2- propylene -1 ketone, Z-11, a tetramethylpyrazine analogue, on cerebral ischemia reperfusion injury and the underlying mechanism. 240-260 g adult male Wistar rats were subjected to middle cerebral artery occlusion for 2 h, followed by 22 h of reperfusion. Z-11 (1.

Robust digital holography design with monitoring setup and reference tilt error elimination.

A robust digital holography recording design is presented to complete the work of switching between in-line and off-axis recording methods. We precisely supervise the off-axis angle in off-axis holography, so that the original reconstructed image can be separated by a minimum off-axis angle. In the design, we can also monitor and remove the negative effects of the reference tilt error in phase-shifting digital holography.

Solitons in PT-symmetric periodic systems with the logarithmically saturable nonlinearity.

We report on the formation and stability of induced solitons in parity-time (PT) symmetric periodic systems with the logarithmically saturable nonlinearity. Both on-site and off-site lattice solitons exist for the self-focusing nonlinearity. The most intriguing result is that the above solitons can also be realized inside the several higher-order bands of the band structure, due to the change of nonlinear type with the soliton power.

Detection and correction of wavefront errors caused by slight reference tilt in two-step phase-shifting digital holography.

A simple and convenient method, without the need for any additional optical devices and measurements, is suggested to improve the quality of the reconstructed object wavefront in two-step phase-shifting digital holography by decreasing the errors caused by reference beam tilt, which often occurs in practice and subsequently introduces phase distortion in the reconstructed wave. The effects of reference beam tilt in two-step generalized interferometry is analyzed theoretically, showing that this tilt incurs no error either on the extracted phase shift or on the retrieved real object wave amplitude on the recording plane, but causes great deformation of the recovered object wavefront. A corresponding error detection and correction approach is proposed, and the formulas to calculate the tilt angle and correct the wavefront are deduced.

Surface lattice solitons in diffusive nonlinear media with spatially modulated nonlinearity.

Two families of gap and twisted surface lattice solitons in diffusive nonlinear periodic media with spatially modulated nonlinearity are reported. It is shown that the existence and stability of such solitons are extremely spatially modulated nonlinearity sensitive. For self-focusing nonlinearity, gap surface solitons belonging to the semi-infinite gap are stable in whole existence domain, twisted surface solitons are also linearly stable in low modulated strength region and a very narrow unstable region near the upper cutoff appears in high modulated strength region.

Diode-pumped Kerr-lens mode-locked Yb:LYSO laser with 61fs pulse duration.

A stable diode pumped Kerr-lens mode-locked (KLM) Yb:LuYSiO5 (Yb:LYSO) laser of generating 61 fs pulses at a central wavelength of 1055.4 nm is experimentally demonstrated. This is, to the best of our knowledge, the first demonstration of femtosecond KLM operation in Yb:LYSO laser, and it is believed that 61 fs is the shortest pulse duration ever produced from an Yb-doped orthosilicate laser.

Low-threshold self-starting femtosecond Ti:sapphire laser.

A low-threshold self-starting Kerr-lens mode-locked Ti:sapphire laser is demonstrated that uses a tight-focusing cavity design in conjunction with a semiconductor saturable-absorber mirror (SESAM). With 3% and 12% output couplers, we achieve mode-locking thresholds as low as 390 and 600 mW, respectively. Stable femtosecond laser pulses with average power of 114 mW are generated at a pump power of 1.