Publications by authors named "Yule Chen"

Time-dependent diffusion MRI (t-dMRI) has potential in characterizing microstructural features; however, its value in imaging endometrioid endometrial adenocarcinoma (EEA) remains uncertain. Patients surgically confirmed with EEA were finally enrolled in our study. The t-dMRI data were acquired using pulsed gradient spin echo sequence and oscillating gradient spin echo sequences.

View Article and Find Full Text PDF

Introduction: Non-functioning adrenal adenomas (NFAs) are typically regarded as benign tumors that lack hormonal secretion. However, emerging evidence has shown that some patients with NFAs and hypertension experience improvements in blood pressure after adrenalectomy, indicating a potential correlation between NFAs and hypertension. Nevertheless, the precise mechanisms that underpin this phenomenon remain elusive.

View Article and Find Full Text PDF

Clear cell renal cell carcinoma (ccRCC) is characterized by Von Hippel Lindau (VHL) gene loss of function mutation, which leads to the accumulation of hypoxia-inducible factor 2α (HIF2α). HIF2α has been well-established as one of the major oncogenic drivers of ccRCC, however, its therapeutic targeting remains a challenge. Through an analysis of proteomic data from ccRCCs and adjacent non-tumor tissues, we herein revealed that Ubiquitin-Specific Peptidase 7 (USP7) was upregulated in tumor tissues, and its depletion by inhibitors or shRNAs caused significant suppression of tumor progression in vitro and in vivo.

View Article and Find Full Text PDF
Article Synopsis
  • Traditional Chinese opera training involves complex skills and cultural knowledge, which may affect brain function; this study examined the neural impacts of such training on actors versus untrained individuals.
  • Twenty trained actors and twenty untrained subjects underwent resting-state fMRI scans to measure differences in brain activity and connectivity.
  • Results showed that actors had lower dALFF in a specific brain region and higher connectivity with other areas, suggesting that long-term training changes brain function; these findings point to a relationship between artistic practice and cognitive ability.
View Article and Find Full Text PDF

Background: The E1A-associated protein p300 (p300) has emerged as a promising target for cancer therapy due to its crucial role in promoting oncogenic signaling pathways in various cancers, including prostate cancer. This need is particularly significant in prostate cancer. While androgen deprivation therapy (ADT) has demonstrated promising efficacy in prostate cancer, its long-term use can eventually lead to the development of castration-resistant prostate cancer (CRPC) and neuroendocrine prostate cancer (NEPC).

View Article and Find Full Text PDF

While large-scale artificial intelligence (AI) models for protein structure prediction and design are advancing rapidly, the translation of deep learning models for practical macromolecular drug development remains limited. This investigation aims to bridge this gap by combining cutting-edge methodologies to create a novel peptide-based PROTAC drug development paradigm. Using ProteinMPNN and RFdiffusion, we identified binding peptides for androgen receptor (AR) and Von Hippel-Lindau (VHL), followed by computational modeling with Alphafold2-multimer and ZDOCK to predict spatial interrelationships.

View Article and Find Full Text PDF

Background: Finding the oncogene, which was able to inhibit tumor cells intrinsically and improve the immune answers, will be the future direction for renal cancer combined treatment. Following patient sample analysis and signaling pathway examination, we propose p21-activated kinase 4 (PAK4) as a potential target drug for kidney cancer. PAK4 exhibits high expression levels in patient samples and plays a regulatory role in the immune microenvironment.

View Article and Find Full Text PDF

Peptide drugs offer distinct advantages in therapeutics; however, their limited stability and membrane penetration abilities hinder their widespread application. One strategy to overcome these challenges is the hydrocarbon peptide stapling technique, which addresses issues such as poor conformational stability, weak proteolytic resistance, and limited membrane permeability. Nonetheless, while peptide stapling has successfully stabilized α-helical peptides, it has shown limited applicability for most β-sheet peptide motifs.

View Article and Find Full Text PDF
Article Synopsis
  • CDK4/6 inhibitors have shown effectiveness in treating certain cancers like breast cancer, but their resistance mechanisms in other cancer types remain uncertain.
  • Research reveals that MYC gene amplification leads to resistance against CDK4/6 inhibitors in bladder, prostate, and breast cancer cell lines by promoting the degradation of the RB1 protein.
  • A new compound called A80.2HCl can degrade MYC, restore RB1 levels, and, when combined with CDK4/6 inhibitors, significantly reduce tumor growth in animal models.
View Article and Find Full Text PDF

Background: Prostate leucine zipper (PrLZ) is a prostate-specific protein, and our previous study demonstrated that PrLZ enhances the malignant progression of prostate cancer (Pca). However, the roles of PrLZ in epithelial to mesenchymal transition (EMT) remain unknown.

Methods: Quantitative real-time PCR (qRT-PCR), immunohistochemical (IHC) staining, hematoxylin-eosin (HE) staining, and western blotting were used to analyze the expression of protein and genes level in human PCa cell lines.

View Article and Find Full Text PDF

Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis, and the androgen receptor regulates prostate cancer (PCa) progression. It is unclear whether the androgen receptor regulates the recruitment of prostate cancer cells to the bone microenvironment, even bone metastases, through exosomes. Here, we found that exosomes isolated from PCa cells after knocking down androgen receptor (AR) or enzalutamide treatment can facilitate the migration of prostate cancer cells to osteoblasts.

View Article and Find Full Text PDF

Background: The enhancer of zeste homolog 2 (EZH2) plays an important role in the tumor microenvironment (TME), and EZH2 in shaping the epigenetic landscape of CD8 T cell fate and function, with a particular emphasis on cancer. Here, high EZH2 expression always leads to less CD8 T cell infiltration. However, clear cell renal cell carcinoma (ccRCC) is reportedly a "hot" tumor, with contradictory high EZH2 expression.

View Article and Find Full Text PDF

Chromodomain-helicase-DNA-binding protein 1 (CHD1) deletion is among the most common mutations in prostate cancer (PCa), but its role remains unclear. In this study, RNA sequencing was conducted in PCa cells after clustered regularly interspaced palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9)-based CHD1 knockout. Gene set enrichment analysis (GSEA) indicated upregulation of hypoxia-related pathways.

View Article and Find Full Text PDF

Androgen receptor splice variant-7 (AR-V7), one of the major driving factors, is the most attractive drug target in castration-resistant prostate cancer (CRPC). Currently, no available drugs efficiently target AR-V7 in clinical practice. The DNA binding domain (DBD) is indispensable for the transcriptional activity of AR full length and AR splice variants, including AR-V7.

View Article and Find Full Text PDF
Article Synopsis
  • Aldosterone-producing adenoma (APA) is linked to endocrine hypertension and other diseases like metabolic syndrome, but the mechanisms are not fully understood.
  • Researchers conducted a study using metabolomics to compare serum metabolites between patients with essential hypertension (EHT) and those with APA, as well as APA patients before and after adrenalectomy.
  • The study identified significant differences in metabolites related to cardiovascular issues, obesity, and diabetes between APA and EHT patients, notably showing that some harmful metabolite levels were reduced after surgery, suggesting that APA influences cardiovascular and metabolic diseases by affecting serum metabolite levels.
View Article and Find Full Text PDF
Article Synopsis
  • Aberrant activation of chaperone-mediated autophagy (CMA) is implicated in the development of various cancers, including prostate cancer (PCa), primarily through the action of the prostate-specific gene TPD52, which promotes tumor growth.
  • TPD52 interacts with the heat shock protein HSPA8 to enhance CMA activity, thereby supporting PCa cell proliferation and resistance to stress, with its function being regulated by acetylation mediated by KAT2B and HDAC2.
  • Inhibition of HDAC2 increases TPD52 acetylation, disrupting its interaction with HSPA8 and impairing CMA, which suggests that targeting this pathway could be a viable strategy for controlling the progression of prostate cancer.
View Article and Find Full Text PDF

We investigated the mechanisms affecting tumor progression and survival outcomes in -mutated () clear cell renal cell carcinoma (ccRCC) patients. ccRCC tissues contained higher numbers of mast cells and lower numbers of CD8 and CD4 T cells than tissues from ccRCC patients. Hierarchical clustering, pathway enrichment and GSEA analyses demonstrated that mutations promote tumor progression by activating hypoxia inducible factor (HIF)-related signaling pathways and increasing expression of vascular endothelial growth factor family genes.

View Article and Find Full Text PDF

Background: The aim of this study is to describe the prevalence and mortality of bladder cancer (BCa) using data obtained in the Global Burden of Disease study performed in 2017 (GBD 2017).

Methods: Data on BCa for 2017, including prevalence, mortality, and disability-adjusted life years (DALYs), were obtained from GBD 2017 at the global, regional, and national levels. We also analyzed the association of BCa burden with the country development level.

View Article and Find Full Text PDF

Background: Recent studies indicate that androgen deprivation therapy (ADT), the main therapeutic approach for metastatic prostate cancer (PCa), accelerates PCa invasion and metastasis. Annexin A1 (ANXA1) is a Ca-regulated phospholipid-binding protein that can promote PCa migration and invasion.

Aim Of The Study: The aim of this study is to determine whether ANXA1 is regulated by ADT and participates in PCa progression after ADT, and to explore the possible mechanism of ANXA1-mediated PCa migration.

View Article and Find Full Text PDF

Exosomes secreted by cancer cells play important roles in tumor progression by interacting with cell receptors. Renal cancer derived exosomes contain miRNAs which are associated with cell proliferation and invasion. Micro RNA 9-5 (miR-9-5) is highly expressed in the serum of renal cancer patients with advanced (tumor size - node - metastasis) TNM stage and Fuhrman grade.

View Article and Find Full Text PDF

Prostate cancer (PCa) is the second leading cause of cancer-associated mortality in men. Speckle-type pox virus and zinc finger protein (SPOP), the most frequently mutated gene in PCa, functions as a tumor suppressor via degradation of cancer-promoting substrates. However, its upstream regulation in PCa metastasis remains poorly determined.

View Article and Find Full Text PDF

Clear cell renal cell carcinoma (ccRCC), the most frequent subtype of renal cell carcinoma (RCC), is characterized by high relapse rate and mortality. Long non-coding RNAs (lncRNAs) are critical participants during cancer development. LncRNA DARS antisense RNA 1 (DARS-AS1), a newly-found lncRNA, is not specifically reported in ccRCC.

View Article and Find Full Text PDF

Prostate cancer (PCa) is a common malignancy with a high tendency for metastasis. Epithelial-mesenchymal transition (EMT) plays a crucial role in PCa metastasis. Metabolic reprogramming offers metabolic advantages for cancer development and could result in the discovery of novel targets for cancer therapy.

View Article and Find Full Text PDF

Early studies suggest that the androgen receptor (AR) may play differential roles in influencing prostate cancer (PCa) and bladder cancer (BCa) metastasis, but the underlying mechanisms remain unclear. Here, we found that the AR might function via differentially altering vasculogenic mimicry (VM) formation to either decrease PCa metastasis or increase BCa metastasis. Mechanism dissection showed that the AR could differentially alter the expression of the VM marker SLPI through miR-525-5p to regulate SLPI; moreover, it could either increase miR-525-5p transcription in PCa or decrease it in BCa via binding to different androgen-response-elements (AREs) located at different positions in the miR-525 precursor promoter.

View Article and Find Full Text PDF

Background: We previously reported the presence of prostate-specific antigen (PSA) in the stromal compartment of benign prostatic hyperplasia (BPH). Since PSA is expressed exclusively by prostatic luminal epithelial cells, PSA in the BPH stroma suggests increased tissue permeability and the compromise of epithelial barrier integrity. E-cadherin, an important adherens junction component and tight junction regulator, is known to exhibit downregulation in BPH.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionhaoe6bjnuhb84jmhn0vin1t9ga2tr1um): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once