Publications by authors named "Yulan Lin"

Background: Nuclear Magnetic Resonance (NMR) is extensively utilized in research as a non-invasive technique for investigating molecular structures and composite components. The spatiotemporal encoding (SPEN) technique effectively accelerates multi-dimensional NMR experiments. In ultrafast SPEN NMR, the acquired data are divided into odd and even segments corresponding to the positive and negative gradients during the decoding stage, respectively.

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  • This study investigates the role of methylation in the hsa-miR-3665 promoter and its connection to the prognosis of esophageal squamous cell carcinoma (ESCC).
  • Researchers found that hsa-miR-3665 was significantly less expressed in ESCC tumor tissue compared to normal tissue, indicating potential epigenetic regulation.
  • High levels of methylation in the hsa-miR-3665 promoter were linked to poorer patient outcomes, suggesting it could serve as a useful biomarker for predicting ESCC progression.
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Background: Early recognition and accurate diagnosis are particularly important in the context of gastric cancer. This study mainly aimed to investigate primary care physicians' (PCPs') clinical behaviour and their readiness to consider investigation or referral for symptoms possibly indicative of gastric cancer.

Design: Cross-sectional study.

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Numerous H-H couplings contribute to complex multiplets in H nuclear magnetic resonance spectroscopy, leading to an ambiguous spectral assignment, particularly for strongly coupled protons. Although the PSYCHE approach has proven to be effective in simplifying complex spectra by collapsing couplings, the PSYCHE pure shift spectrum of strongly coupled protons always suffers from sideband artifacts and baseline oscillations, which impede spectral identification. Herein, we introduce a novel universal technique designed to separate artifacts from the desired absorption-mode pure shift signals.

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To investigate the relationship between father involvement in parenting and mental health problems among children and adolescents in rural China. The Rural Children's Mental Health dataset includes mental health information from 2,489 children and adolescents aged 5-16 in seven provinces in China. The relationship between father involvement in children and adolescents depression risk and anxiety was analyzed by Spearman's correlation analysis, logistic regression analysis, and restricted cubic spline.

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Background: The COVID-19 pandemic is bringing about substantial changes in health care systems, leading to a significant shift toward telemedicine for the delivery of health care services.

Objective: This study aims to examine the relationship between perceived usefulness and ease of use of telemedicine services and their association with the behavioral intention to use telemedicine.

Methods: An anonymous cross-sectional survey was conducted in China.

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Objective: This study aimed to investigate the level of family caregivers' (FC) burden and the extent to which patient- and caregiver-related factors influence the caregiving burden among FCs of urologic cancer (UC) patients.

Method: A cross-sectional survey was conducted on caregivers of UC patients who sought cancer care. The modified caregiver strain index (MCSI) was used to assess FC burden.

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Background: This study aimed to determine the intention and willingness-to-pay (WTP) of Chinese parents/guardians to vaccinate their children with the EV-71 vaccine. Knowledge levels about hand, foot, and mouth disease (HFMD) and the EV-71 vaccine were also investigated.

Methods: A cross-sectional, self-administered online survey was conducted between November 2022 and March 2023.

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Background: Although Zika virus infection is rarely reported now, continuous prevention is needed to achieve sustained eradication. This study aimed to explore the knowledge gaps, risk perception and preventive measures against Zika virus infection (ZIKV) in pregnant women in Malaysia.

Methods: We conducted in-depth virtual interviews with pregnant women between February and April 2022.

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Background: Regular follow-up and medication can effectively reduce the risk of adverse outcomes for patients with hypertension. This study aimed to explore the temporal-spatial distribution characteristics and associated socioeconomic factors of visiting frequency for rural patients with hypertension in Fujian province from 2011 to 2016.

Methods: The medical records of patients with hypertension were abstracted from the database of New Rural Cooperative Medical Scheme.

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The primary objective of this paper is to serve as a valuable resource for policymakers who are confronted with the evolving landscape of the coronavirus disease 2019 (COVID-19), considering both free and cost-based vaccination approaches. The potential consequences of shifting from free to cost-based vaccination are explored, encompassing its impact on global vaccine equity and prioritization, economic well-being, healthcare systems and delivery, public health policies, and vaccine distribution strategies. Examining past studies on willingness to pay for the initial COVID-19 vaccine dose and booster shots provides insights into how individuals value COVID-19 vaccinations and underscores the significance of addressing issues related to affordability.

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The stability of microbial communities, especially among core taxa, is essential for supporting plant health. However, the impacts of disease infection on the stability of rhizosphere fungal core microbiome remain largely unexplored. In this study, we delved into the effects of root rot infestation on the community structure, function, network complexity, and stability of Sanqi fungal core microbiomes, employing amplicon sequencing combined with co-occurrence network and cohesion analyses.

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Article Synopsis
  • This study investigates the characteristics and azole resistance mechanisms of Candida parapsilosis isolates in China.
  • Out of 2318 isolates tested, 2.4% were resistant to fluconazole, especially prevalent among ICU patients, highlighting significant genetic clustering and transmission.
  • Key mutations were identified, including Erg11Y132F, which contributes to resistance, along with others that play a role in increasing resistance levels and cross-resistance to different azoles.
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Arbuscular mycorrhizal fungi (AMF) and phosphate solubilizing bacteria (PSB) are involved in phosphorus (P) mobilization and turnover; however, the impact of their interaction on plant P absorption and organic P mineralization in the hyphosphere (rootless soil) are unknown. This study examined the interactive effects of two native microorganisms, namely and , and the effects of co-inoculation of both microorganisms on organic P mineralization and the subsequent transfer to using a three-compartment microcosm with a nylon mesh barrier. The results demonstrated that the co-inoculation treatment (AMF + PSB) significantly increased the plant P content and biomass accumulation in .

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The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development. This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts.

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  • * Out of 84 CRE strains detected, most were resistant to common antibiotics, with the predominant carbapenemase gene being found in 90.8% of cases and ST11 identified as the most common sequence type.
  • * The results underscore the urgent need for effective infection control measures in ICUs to combat the high prevalence of CRE and prevent further spread of these resistant bacteria.
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Continuous cultivation of medicinal plants can disrupt the rhizosphere's microbial community. There is still a need to know about the beneficial bacterial community, their putative drivers, and the potential functions they may have. This study used different growth years of Sanqi ginseng () with root rot to look at the beneficial microbial community structure, the function of microbial carbon source utilization, and the function of rhizosphere soil metabolism.

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Objective: To establish a model for predicting the disease-specific survival (DSS) of patients with oral squamous cell carcinoma (OSCC).

Methods: Patients diagnosed with OSCC from the Surveillance, Epidemiology, and End Results (SEER) database were enrolled and randomly divided into development (n = 14,495) and internal validation cohort (n = 9625). Additionally, a cohort from a hospital located in Southeastern China was utilized for external validation (n = 582).

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Objectives: This study aimed to identify the determinants of gastric cancer screening attendance among individuals aged 40 years in a region with high gastric cancer in China.

Design: An anonymous, cross-sectional survey was conducted between October 2021 and March 2022.

Setting: A self-administered online survey was conducted in Fujian Province in Southeastern China.

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Objective: To assess the prognostic role of pretreatment lymphocyte percentage (LY%) for patients with oral squamous cell carcinoma (OSCC).

Methods: A large-scale prospective cohort study between July 2002 and March 2021 was conducted. Propensity score-matched (PSM) analysis and inverse probability of treatment weighting (IPTW) analysis were performed to adjust for potential confounders.

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The gene cluster encodes colibactin, which can cause DNA damage and enhance the virulence in Escherichia coli. However, the role of the gene in Klebsiella pneumoniae has not been fully discussed. The aim of this study was to analyze the relationship between the gene cluster and virulence factors, as well as to assess antibiotic resistance and biofilm formation capacity in clinical isolates of Klebsiella pneumoniae.

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Introduction: This study aimed to shed light on how young people from low-income families were responding to COVID-19.

Methods: This cross-sectional study recruited young people aged between 18 and 24 years from the low-income-group communities. A convenience sampling approach was used.

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Introduction: This study aims to shed light on parent-child relationships and the psychological health of parents from low-income families after the easing of the COVID-19 pandemic restrictions.

Methods: This cross-sectional study recruited 553 parents of children aged 13-24 years in low-income community settings. The Parent-Child Conflict scale of the Parental Environment Questionnaire (PEQ) was used to measure parent-child conflict.

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The anti-vaccination movement was an ongoing issue in Malaysia, a Muslim-majority country, even before the COVID-19 pandemic. It is unclear whether the introduction of new COVID-19 vaccines would similarly provoke anti-vaccine sentiments. This study analyzed COVID-19 anti-vaccine sentiments in the Malaysian community.

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Background: Dengue is prevalent among the indigenous community due to impoverished living conditions near the forest fringe areas and lack of health awareness. The study aims to determine the effect of a dengue awareness calendar on knowledge, belief, and practices (KBP) among the indigenous population.

Method: A cross-sectional study was conducted in nine selected indigenous villages in Selangor, Malaysia.

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