Association of PM-bound multiple metals co-exposure with early cardiovascular damage: A panel study in young adults combining metabolomics.

The association of individual metals in PM with cardiovascular damage has been established in previous studies, but there are fewer studies on co-exposure to multiple metals and potential metabolic alterations in cardiovascular damage. To investigate the early cardiovascular effects of multiple metals and the mediating effects of metabolites, we conducted a panel study on young adults from 2017 Winter to 2018 Autumn in Caofeidian, China. A total of 180 serum samples were analyzed for metabolomic profiles using liquid chromatography-mass spectrometry.

Predicting the Potential Distribution of under Climate Change Scenarios Using a Maximum Entropy Model.

, as one of the Traditional Chinese Medicinal materials, possesses a variety of pharmacological activities and high medicinal value. However, in recent years, the wild resources of have been severely depleted due to global climate change and human activities, and artificial cultivation faces problems such as unstable yield and active ingredient content. This poses a serious obstacle to the development and utilization of its resources.

The role of systemic inflammation and oxidative stress in the association of particulate air pollution metal content and early cardiovascular damage: A panel study in healthy college students.

Exposure to fine particulate matter (PM) has been associated with adverse cardiovascular outcomes. However, the effects of toxic metals in PM on cardiovascular health remain unknown. To investigate the early cardiovascular effects of specific PM metal constituents at the personal level, we conducted a panel study on 45 healthy college students in Caofeidian, China.

Fabrication of Ce-doped DUT-52 as a sorbent for dispersive solid phase extraction of estrogens in human urine samples.

A cerium (Ce)-doped metal-organic framework composite (Ce/DUT-52) was prepared by using a solvothermal method and was explored as a sorbent for dispersive solid phase extraction (DSPE) of three estrogens (α-estradiol, estrone, and hexestrol) in human urine samples. After doping with Ce(III), Ce/DUT-52 exhibited more attractive features involving a higher specific surface area (774.7 m g) and zeta potential (31.

Combined effects of exposure to polycyclic aromatic hydrocarbons and metals on oxidative stress among healthy adults in Caofeidian, China.

Exposure to polycyclic aromatic hydrocarbons (PAHs) and metals is associated with many adverse effects on human health, accompanied by oxidative stress. This study aimed to investigate the effects of co-exposure to PAHs and metals on oxidative stress in healthy adults. A preliminary longitudinal panel study was conducted between 2017 and 2018 in 45 healthy college students in Caofeidian, China.

Inhalation bioaccessibility, health risk assessment, and source appointment of ambient PM-bound polycyclic aromatic hydrocarbons (PAHs) in Caofeidian, China.

The inhalation bioaccessibility of polycyclic aromatic hydrocarbons (PAHs) is significant for accurately assessing the health risks posed by PM-bound PAHs. In this study, 96 PM samples from Caofeidian, China, were investigated for PM-bound PAH source appointment and bioaccessibility assessment during four seasons. PAH potential sources were identified by positive matrix factorization.

Fast magnetic solid-phase extraction using an FeO-NH@MOF material for monohydroxy polycyclic aromatic hydrocarbons in urine of coke-oven workers.

In this work, a magnetic material (Fe3O4-NH2@MIL-101) was successfully prepared, and the material was used as a sorbent for the magnetic solid-phase extraction (MSPE) of trace level monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) from urine samples for the first time. The target analytes were quantified by high performance liquid chromatography coupled with fluorescence detection (HPLC-FLD). The MSPE key factors, which include the amount of adsorbent, extraction time, pH, the effect of salt, eluting solutions and eluant volume, were systematically optimized.

Source Identification and Health Risk Assessment of Polycyclic Aromatic Hydrocarbon-Enriched PM in Tangshan, China.

Tangshan city in Hebei Province is one of the most heavily polluted cities in China, with substantial industrial emissions. The development of effective air pollution emission reduction policies requires knowledge of the sources and health risks of polycyclic aromatic hydrocarbon (PAH)-enriched fine particulate matter (PM ). We investigated the seasonal variation and source apportionment of 16 priority PAH-enriched PM samples in Tangshan during 2014 and 2015, and we assessed the health risks associated with inhalation exposure to PAHs.

[Determination of four hydroxyl polycyclic aromatic hydrocarbons in urine by solid-phase extraction with monolithic column coupled with high performance liquid chromatography].

A method based on monolithic column solid-phase extraction (SPE) coupled with high performance liquid chromatography (HPLC) was developed for the simultaneous determination of four hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs) in urine.A poly (butyl methacrylate-co-ethylene dimethacrylate) monolithic column was prepared in a syringe and was used as the sorbent.The parameters influencing SPE, such as loading volume, washing solvent, eluent, and elution volume, were investigated in detail.

Magnetic metal-organic frameworks for fast and efficient solid-phase extraction of six Sudan dyes in tomato sauce.

Magnetic solid-phase extraction is an effective and useful technique to preconcentrate trace analytes from food samples. In this study, a magnetic trimeric chromium octahedral metal-organic framework (FeO-NH@MIL-101) was fabricated and characterized. FeO-NH@MIL-101 was applied as an adsorbent of magnetic solid-phase extraction combined with high performance liquid chromatography to effectively isolate and simultaneously determine six Sudan dyes (Para Red, Sudan I-IV, and Sudan Red 7B) from tomato sauce.

Lead selenide nanoparticles-induced oxidative damage of kidney in rats.

Objective: To investigate the effect of lead selenide nanoparticles (nano PbSe) on kidney in rats.

Method: Specific pathogen free SD rats were randomly divided into 4 groups (8 rats/group), and injected with of 0mg/kg (control group), 10mg/kg (low dose group), 20mg/kg (middle dose group), or 30mg/kg (high dose group) nano PbSe respectively. Seven weeks after injection, the serum was taken from rats for the detection of blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA).

Effective extraction and simultaneous determination of Sudan dyes from tomato sauce and chili-containing foods using magnetite/reduced graphene oxide nanoparticles coupled with high-performance liquid chromatography.

A simple, effective, and robust magnetic solid-phase extraction method was developed using magnetite/reduced graphene oxide nanoparticles as the adsorbent for the simultaneous determination of Sudan dyes (I, II, III, and IV) in foodstuffs. The magnetite/reduced graphene oxide nanoparticles were characterized by X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometry. The extraction parameters including extraction time, elution solution, and elution time and volume were investigated in detail.

[Determination of five avermectins in bovine liver by on-line solid-phase extraction with hydrophobic monolithic column coupled with high performance liquid chromatography-tandem mass spectrometry].

A method based on on-line solid-phase extraction (SPE) with hydrophobic monolithic column coupled with high performance liquid chromatography-tandem mass spectrometry was developed for the simultaneous determination of five avermectins in bovine liver. A poly(butyl methacrylate-co-ethylene dimethacrylate) monolithic column was used as the sorbent. The parameters influenced on on-line SPE and separation process such as the loading mobile phase, the eluting flow rate and the solvent for the separation were investigated in detail.

The oxidative damage and inflammatory response induced by lead sulfide nanoparticles in rat lung.

Lead sulfide nanoparticles (PbS NPs) are one important nanoparticle materials which is widely used in photoelectric production, but its potential health hazard to respiratory system is not clear. This study aimed to explore the possible mechanism of lung injury induced by PbS NPs. Male SD rats were treated with nanoparticles of 60 nm and 30 nm lead sulfide.

[The change of pulmonary surfactant protein of rat following silica exposure].

Objective: To investigate the change of lung surfactant protein (SP) A,B,C,D of rats following silica dust exposure in order to provide the evidences for the early diagnosis indices or therapy of silicosis.

Methods: 60 male SD rats were randomly divided into silica group, and corresponding controls group. Rats in silica group were administrated 1 ml silica solution by intratracheal instillation at dose of 50 mg/ml.

[Effects of acrylamide on the permeability of blood cerebrospinal fluid barrier in rats].

Objective: To explore the effects of acrylamide on the permeability of blood cerebrospinal fluid barrier (BCB) and tight junction protein ZO-1 of choroid plexus in rats and to provide a theoretical basis for explaining the mechanism of nerve injury induced by acrylamide.

Methods: Thirty two male Sprague-Dawley rats were randomly divided into ACR and control groups. ACR group was exposed to 20 mg/kg ACR daily for 5 days a week by intraperitoneal injection (i.

[Preliminary study of biomarker in blood or cerebrospinal fluid of rat following manganese exposure].

Objective: To explore the biomarkers of manganese exposure by measuring the manganese (Mn) and iron (Fe) level as well as the mRNA change of Hepcidin, divalent metal-ion transporter-1 (DMT1) and Parkin-2, one of genes related to Parkinson disease in body fluid and brain tissues of rat.

Methods: Male Sprague-Dawley rats were administered (i.p) either MnCl2 solution (6 mg Mn/kg) or the same volume saline, 5 times per week and for 4 weeks.

[In situ resonance Raman spectra of organic pigments in freshwater cultured pearls].

In situ resonance Raman spectra of Chinese freshwater pearls were collected and analysed systematically with three different excitation wavelengths at lambda = 514, 633 and 785 nm. At the same time, the Raman spectra of eggshells of Pomacea canaliculata were also collected under the same experimental conditions in order to compare with pearls' Raman spectra. The conclusions were as follows: (1) Frequency dispersions of Raman spectra of organic pigments were obviously observed in Raman spectra of pearls.