Close Range and High-Resolution Detection of Vibration by Ultrasonic Wave Using Silicon-on-Nothing PMUTs.

This article presents a novel method for close-range, high-resolution ultrasonic time-of-flight (ToF) ranging using piezoelectric micromachined ultrasonic transducers (PMUTs) operating below the device resonance in air. The proposed method involves cross correlation techniques to accurately detect the reflected echo signals despite the presence of ringdown signal interference. For the experiments, a high fill-factor array of silicon-on-nothing (SON) PMUTs was used to enhance the signal-to-noise ratio (SNR).

Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator.

This article presents an in-depth exploration of the acoustofluidic capabilities of guided flexural waves (GFWs) generated by a membrane acoustic waveguide actuator (MAWA). By harnessing the potential of GFWs, cavity-agnostic advanced particle manipulation functions are achieved, unlocking new avenues for microfluidic systems and lab-on-a-chip development. The localized acoustofluidic effects of GFWs arising from the evanescent nature of the acoustic fields they induce inside a liquid medium are numerically investigated to highlight their unique and promising characteristics.

Microfabricated acoustofluidic membrane acoustic waveguide actuator for highly localized in-droplet dynamic particle manipulation.

Precision manipulation techniques in microfluidics often rely on ultrasonic actuators to generate displacement and pressure fields in a liquid. However, strategies to enhance and confine the acoustofluidic forces often work against miniaturization and reproducibility in fabrication. This study presents microfabricated piezoelectric thin film membranes made silicon diffusion for guided flexural wave generation as promising acoustofluidic actuators with low frequency, voltage, and power requirements.

Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis.

Recently, preparation and screening of compound libraries remain one of the most challenging tasks in drug discovery, biomarker detection, and biomolecular profiling processes. So far, several distinct encoding/decoding methods such as chemical encoding, graphical encoding, and optical encoding have been reported to identify those libraries. In this paper, a simple and efficient surface-enhanced Raman spectroscopic (SERS) barcoding method using highly sensitive SERS nanoparticles (SERS ID) is presented.

Nanoslit membrane-integrated fluidic chip for protein detection based on size-dependent particle trapping.

This paper describes the fabrication of a nanoslit membrane-integrated fluidic chip (Nanoslit-Chip) used for trapping and concentrating micro-/nano-particles of desired size and its application in detecting biological molecules based on target-induced particle aggregation. To trap particles of a specific size, a large scale uniform sized nanoslit fluid channel array is fabricated on a silicon dioxide membrane. A small number of fluorescence labeled particles in a large volume of solution are concentrated into a monolayer of particles in a small nanoslit membrane, which enables us to effectively quantify them via fluorescence intensity.

Bead affinity chromatography in a temperature-controllable microsystem for biomarker detection.

This paper describes a temperature-controllable bead affinity chromatography (BAC) in a microsystem for biomarker detection, and preparing samples for matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) analysis. Cancer marker proteins were captured in the microsystem by BAC with RNA aptamer-immobilized microbeads. The captured proteins were then denatured and released from the microbeads by controlling temperature.