Intervertebral disc degeneration (IVDD), is one of the leading causes of low back pain. Inflammation is considered to be the main pathophysiological process of IVDD. The nucleotide-binding domain and leucine-rich pyrin domain containing 3 (NLRP3) inflammasome-mediated inflammatory responses are critically involved in the progression of IVDD.
View Article and Find Full Text PDFBackground: Lung adenocarcinoma (LUAD) causes leading death worldwide. Mitophagy and lactate metabolism accumulation are distinctive features of LUAD. We aimed to identify lactate-related genes (LRGs) signatures based on mitophagy for predicting prognosis and immune response in LUAD.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2024
With the evolution of medical models and diverse healthcare service needs, nurse-led clinics (NLCs) have gained increasing attention. China began experimenting with NLCs in 1997 and their development has accelerated in recent years. This study reviews the current status, management practices, and innovative advancements in NLCs in China and compares them with those in other countries or regions.
View Article and Find Full Text PDFNPJ Biofilms Microbiomes
November 2024
Rumen microbiotas are known to influence the fat deposition (FD) in sheep, but controversy over causality remains unresolved. Here, we performed microbiome-wide association studies (MWAS), microbiome genome-wide association analysis (mbGWAS) and bidirectional mendelian randomization (MR) analyses on 1,150 sheep with genotype data from whole-genome resequencing, 16S rRNA sequencing and multilevel FD-traits data. We quantified the proportion of individual variation in FD-traits explained by host genetics, rumen microbiota, and their interaction effects.
View Article and Find Full Text PDFIn the era of the Internet of Things (IoT), the demand for accurate positioning services has become increasingly critical, as location-based services (LBSs) depend on users' location data to deliver contextual functionalities. While the Global Positioning System (GPS) is widely regarded as the standard for outdoor localization due to its reliability and comprehensive coverage, its effectiveness in indoor positioning systems (IPSs) is limited by the inherent complexity of indoor environments. This paper examines the various measurement techniques and technological solutions that address the unique challenges posed by indoor environments.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs, yet its underlying mechanisms remain unclear, and precise biomarkers are lacking. In this study, we employed Mendelian randomization and HEIDI tools to comprehensively analyze large-scale Genome-Wide Association Study (GWAS) and expression Quantitative Trait Loci (eQTL) data, leading to the identification of seven novel potential functional genes associated with SLE, including BLK, ELF1, STIM1, B3GALT6, APOLD1, INPP5B, and FHL3. Subsequent investigations revealed a significant downregulation of ELF1 gene expression in CD4 T cells of SLE patients compared to healthy controls.
View Article and Find Full Text PDFIncreasing frequency, intensity and duration of marine heatwaves (MHWs) are supposed to affect coastal biological production in different regions to different extents. To understand how MHWs impact coastal primary productivity and community succession of phytoplankton and assess the changes in resilience of phytoplankton communities, we conducted a mesoscale enclosure experiment simulating a MHW in the coastal water of southern China. After 8 days of the MHW (+3 °C) treatment, community biomass was significantly lower than the control's, and primary productivity per volume of water was reduced by about 56%.
View Article and Find Full Text PDFObjective: This study endeavors to clarify the impact of venous aneurysms (VA) on hemorrhagic risk in brain arteriovenous malformations (AVMs) and uncover potential hemodynamic mechanisms, utilizing quantitative digital subtraction angiography (QDSA) technology and survival dataset.
Methods: Patients were enrolled in a multicenter prospective collaboration registry between August 2011 and August 2021, and subsequently categorized into the VA and non-VA cohorts. Using propensity score-matched survival analysis, we quantitatively assessed the natural risk of hemorrhagic stroke in these two cohorts.
Physical activity, as a promising complementary therapy, has shown considerable potential for reducing chemotherapy-related cardiotoxicity (CTRCT) and enhancing cardiorespiratory function (CRF). This study aimed to systematically assess the effects of physical activity on CTRCT and CRF in various cancer survivors receiving chemotherapy. A systematic review and meta-analysis was conducted.
View Article and Find Full Text PDFAmidst the pursuit of sustainable development and economic prosperity, there has been growing criticism directed towards traditional metrics such as GDP because of their narrow focus on societal well-being and environmental considerations. Therefore, our study shifts its focus from GDP to a more comprehensive measure of wealth, known as inclusive wealth. Our objective is to investigate how technology contributes to the advancement of inclusive wealth encompassing produced, natural, and human capital.
View Article and Find Full Text PDFErythropoietin-induced hepatocyte receptor A2 (EphA2) is a receptor tyrosine kinase that plays a key role in the development and progression of a variety of tumors. This article reviews the expression of EphA2 in gastrointestinal (GI) colorectal cancer (CRC) and its regulation of pyroptosis. Pyroptosis is a form of programmed cell death that plays an important role in tumor suppression.
View Article and Find Full Text PDFWi-Fi fingerprint-based indoor localization methods are effective in static environments but encounter challenges in dynamic, real-world scenarios due to evolving fingerprint patterns and feature spaces. This study investigates the temporal variations in signal strength over a 25-month period to enhance adaptive long-term Wi-Fi localization. Key aspects explored include the significance of signal features, the effects of sampling fluctuations, and overall accuracy measured by mean absolute error.
View Article and Find Full Text PDFDefects in chaperone-mediated autophagy (CMA) are associated with cellular senescence, but the mechanism remains poorly understood. Here, we found that CMA inhibition induced cellular senescence in a calcium-dependent manner and identified its role in TNF-induced senescence of nucleus pulposus cells (NPC) and intervertebral disc degeneration. Based on structural and functional proteomic screens, PLCG1 (phospholipase C gamma 1) was predicted as a potential substrate for CMA deficiency to affect calcium homeostasis.
View Article and Find Full Text PDFThe fracture mechanism and macro-properties of SVSAC were studied using a novel test system combined with numerical simulations, which included three-point bending beam tests, the digital image correlation (DIC) technique, scanning electron microscopy (SEM), and ABAQUS analyses. In total, 9 groups and 36 specimens were fabricated by considering two critical parameters: initial notch-to-depth ratios (/) and concrete mix components (seawater and volcanic scoria coarse aggregate (VSCA)). Changes in fracture parameters, such as the load-crack mouth opening displacement curve (-CMOD), load-crack tip opening displacement curve (-CTOD), and fracture energy (), were obtained.
View Article and Find Full Text PDFChemotherapy is an important factor leading to male infertility. It is crucial to discover safe and effective treatments to prevent male reproductive injury caused by chemotherapy. The polysaccharide peptide (GLPP) has multiple pharmacological activities.
View Article and Find Full Text PDFThe mass mortality of Pacific oyster Crassostrea gigas has become a severe ecological and economic concern to Chinese aquaculture, which is proposed to be linked to the phytoplankton community in the farming waters. In the present study, both field and laboratory experiments were conducted to identify the phytoplankton taxa associated with oyster mortality and explore the molecular mechanism by which they affect the physiological health of oysters. The field experiment showed that more serious mortality of oysters was observed in the North Yellow Sea from July to September in 2018 (average survival rate of 75.
View Article and Find Full Text PDFObjective: To investigate the feasibility and performance of 4D flow MRI accelerated by compressed sensing (CS) for the hemodynamic quantification of intracranial artery and venous sinus.
Materials And Methods: Forty healthy volunteers were prospectively recruited, and 20 volunteers underwent 4D flow MRI of cerebral artery, and the remaining volunteers underwent 4D flow MRI of venous sinus. A series of 4D flow MRI was acquired with different acceleration factors (AFs), including sensitivity encoding (SENSE, AF = 4) and CS (AF = CS4, CS6, CS8, and CS10) at a 3.
Currently, the standard treatment for patients who have undergone percutaneous coronary intervention (PCI) following acute myocardial infarction (MI) involves dual antiplatelet therapy (DAPT) with a combination of aspirin and a potent P2Y12 receptor inhibitor. However, the potential benefits of aspirin were partially constrained by the intolerance of some patients. The safety and efficacy of indobufen, an alternative antiplatelet agents to aspirin, in patients with AMI after PCI are yet to be thoroughly investigated.
View Article and Find Full Text PDFIntervertebral disc degeneration (IVDD) is characterized by the senescence and declining vitality of nucleus pulposus cells (NPCs), often driven by mitochondrial dysfunction. This study elucidates that mesenchymal stem cells (MSCs) play a crucial role in attenuating NPC senescence by secreting mitochondria-containing microvesicles (mitoMVs). Moreover, it demonstrates that static magnetic fields (SMF) enhance the secretion of mitoMVs by MSCs.
View Article and Find Full Text PDFIntroduction: This study is a systematic review and meta-analysis that investigates the efficacy of different surgical methods for treating cervical disc herniation or cervical foraminal stenosis.
Research Question: The research aimed to compare the efficacy of Minimally Invasive Posterior Cervical Foraminotomy (MI-PCF) with anterior approaches, namely Anterior Cervical Discectomy and Fusion (ACDF) and Cervical Disc Arthroplasty (CDA).
Material And Methods: The study included a comprehensive review of eight articles that compared ACDF and MI-PCF, and four articles that compared CDA to MI-PCF.