Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
Hepatitis B virus (HBV) infection remains a major public health problem, causing nearly one million deaths annually. Nucleoporin 153 (NUP153) is known to facilitate the nuclear entry of the human immunodeficiency virus (HIV) nucleocapsids, and recent studies suggest it also plays a role in HBV nucleocapsids nuclear import. We aimed to investigate the impact of NUP153 on HBV replication and its underlying mechanism.
View Article and Find Full Text PDFMCM2 belongs to the microchromosome maintenance [MCM] family and plays an essential role in initiating DNA replication as well as maintaining normal cellular cycle functions. Recent research indicates that there is the abnormal expression of MCM2 in various cancers, such as breast, cervical, ovarian, lung, hepatocellular carcinoma, nephroblastoma, prostate, and pancreatic cancers, where it shows a strong link to tumorigenesis, growth, invasion, migration, and adverse prognosis. Thus, MCM2 could serve as a significant biomarker for the early identification, diagnosis, and prognostic evaluation of multiple cancers.
View Article and Find Full Text PDFThe most common types of renal carcinoma is kidney renal clear cell carcinoma (KIRC). ESM1 is a secreted protein, which involved in, lipids and glucose metabolism, but their role in angiogenesis is contradictory in different disease, especially in KIRC. Bioinformatic analysis confirmed the ESM1 expression and prognosis in KIRC.
View Article and Find Full Text PDFLong-term erosion by acidic solutions in karst regions leads to continuous deterioration of the physical and mechanical properties at the interfaces of engineering structures, adversely affecting their operational performance. To investigate the degradation patterns of the mechanical properties and corrosion mechanisms of the concrete‒limestone composite (CLC) after exposure to acidic corrosion, three kinds of CLC samples treated with acidic solutions of different pH values were fabricated. Mechanical property analysis was conducted via triaxial compression testing methods.
View Article and Find Full Text PDFBackground: The influence of the glucagon-like peptide-1 receptor (GLP-1R) on bone metabolism is well-established. However, it has been observed that single nucleotide polymorphisms (SNPs) in the GLP-1R gene can partially affect its function. Therefore, this study aims to investigate the association between SNPs in the GLP-1R gene and postmenopausal osteoporosis (PMOP) within the Chinese Han population.
View Article and Find Full Text PDFEndotoxemia, caused by lipopolysaccharides, triggers systemic inflammation and myocardial injury by disrupting mitochondrial homeostasis. This study examines the roles of dual specificity phosphatase 1 (Dusp1) and phosphoglycerate mutase family member 1 (Pgam1) in this process. This study utilized cardiomyocyte-specific knockout ( ) and transgenic ( ) mice, alongside knockout ( ) mice, subjected to LPS-induced endotoxemia.
View Article and Find Full Text PDFFerroptosis is a form of programmed cell death that is distinct from apoptosis. The mechanism involves redox‑active metallic iron and is characterized by an abnormal increase in iron‑dependent lipid reactive oxygen species, which results in high levels of membrane lipid peroxides. The relationship between ferroptosis and gynaecological tumours is complex.
View Article and Find Full Text PDFThe decline in sperm parameters among obese males has attracted significant scholarly interest. The intestinal microbiota plays a crucial role in obesity, and investigating the intestinal-reproductive axis may offer a novel molecular approach to addressing the decline in male sperm parameters caused by obesity. To clarify whether probiotics, either alone or in conjunction with metformin, can enhance sperm parameters in obese male mice and assess the underlying mechanisms involved.
View Article and Find Full Text PDFIbrutinib, a potent Bruton's tyrosine kinase inhibitor with marked efficacy against hematological malignancies, is associated with the heightened risk of atrial fibrillation (AF). Although ibrutinib-induced AF is linked to enhanced oxidative stress, the underlying mechanisms remain unclear. This research aimed to explore the molecular mechanism and regulatory target in ibrutinib-induced AF.
View Article and Find Full Text PDFGastric cancer (GC) is a malignant disease worldwide. Angiopoietin-like protein 4 (ANGPTL4) plays a role in pathophysiological processes, including metabolic reprogramming, angiogenesis, proliferation, and metastasis. Current evidence shows conflicting findings regarding the role of ANGPTL4 in the progression of GC.
View Article and Find Full Text PDFCurr Cancer Drug Targets
September 2024
Background: Glucose-regulated protein 78 (GRP78), as a chaperone protein, can protect the endoplasmic reticulum of cells and is expressed to influence chemoresistance and prognosis in cancer. Deoxypodophyllotoxin (DPT) is a compound with antitumor effects on cancers. DPT inhibits the proliferation of osteosarcoma by inducing apoptosis, necrosis, or cell cycle arrest.
View Article and Find Full Text PDFAs one of the factors regulating tumour angiogenesis, angiopoietin-4 (ANGPT4), which plays an important role in promoting tumour proliferation, survival, expansion and angiogenesis, is highly expressed in some tumours, such as lung adenocarcinoma, glioblastoma and ovarian cancer. This may be related to the fact that ANGPT4 affects the blood vessels and lymphatic system of the tumour. Specifically, ANGPT4 could play an effective role in promoting cancer by affecting the tyrosine kinase receptor TIE2, ERK1/2 and PI3K/AKT signalling pathways.
View Article and Find Full Text PDFBackground: Lung adenocarcinoma (LUAD) is one of the respiratory diseases with high mortality and incidence. As an important angiogenic factor, (Endothelial cell-specific molecule 1) ESM1 plays an important role in the occurrence and development of LUAD. However, the role and molecular mechanism of ESM1 on LUAD metabolic reprogramming and angiogenesis remain unclear.
View Article and Find Full Text PDFFront Microbiol
August 2024
Sepsis is a syndrome precipitated by immune dysregulation in response to infection, and represents a pivotal factor in global mortality attributed to diseases. The recent consensus delineates sepsis as a perilous state of organ dysfunction arising from the host's maladaptive reaction to infection. It masks the complexity and breadth of the immune mechanisms involved in sepsis, which is characterized by simultaneous hyperinflammation and immunosuppression.
View Article and Find Full Text PDFBackground: The relationship between obesity and type 2 diabetes with bone health has always been a topic of debate. The weight-adjusted waist index has become a commonly used indicator for assessing central obesity, fat, and muscle mass. However, currently there is no research reporting the association between weight-adjusted waist index and risk of osteoporosis in populations of type 2 diabetes.
View Article and Find Full Text PDFImportance: Many patients with diabetic peripheral neuropathic pain (DPNP) experience inadequate relief, despite best available medical treatments. There are no approved and effective therapies for patients with DPNP in China.
Objective: To evaluate the efficacy and safety of capsules containing γ-aminobutyric acid (GABA) analogue HSK16149 in the treatment of Chinese patients with DPNP.
Context: Existing guidelines often lack sex-specific prevention strategies for type 2 diabetes mellitus (T2DM). Life's Essential 8 (LE8) highlights the role of health behaviors in influencing cardiovascular health (CVH). Due to inherent sex differences, the impact of CVH on T2DM risk may vary between men and women, especially across menopausal stages.
View Article and Find Full Text PDFMultimodal luminescence involves color-tunable and wavelength manageable photon emissions upon variable luminescence pathways in response to different external stimuli, which provides clear visualization and high-level confidentiality for information encryption technologies. Integrating multimodal luminescence into a single matrix is regarded as a feasible strategy but remains a big challenge. In this work, multimodal (photoluminescence, persistent luminescence, upconversion luminescence, and thermally stimulated luminescence) and multicolor luminescence (green, yellow, orange, pink to red) is achieved in CaWO:Yb,Er,Eu phosphor by employing an interplay of traps and rare earth emission centers.
View Article and Find Full Text PDFJ Agric Food Chem
August 2024
Selecting a suitable photocatalyst to establish the Z-scheme heterojunction which is accompanied by effective photogenerated hole and electron separation, is one of the advantageous strategies for efficient photocatalytic solar energy conversion. Therefore, we prepared a ZnInSe nanoparticles photocatalyst to build a double Z-scheme heterojunction with mixed-phase TiO nanofibers, boosting photocatalytic solar fuel preparation. The result of X-ray photoelectron spectroscopy confirmed the existence of interfacial chemical bonds and internal electric fields.
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