Publications by authors named "Yukuan Du"
Effect of Inactivated Vaccines Against SARS-CoV-2 on Immunogenicity Outcome.
Disaster Med Public Health Prep
March 2025
Objectives: The purpose of this study was to measure and examine the levels of IgG, IgM, and Spike antibody induced by inactivated vaccines, including CoronaVac and BBIBP-CorV.
Methods: Two groups of healthy adults over 18 years old (50 participants per group), who had previously received 1 dose of either BBIBP-CorV or CoronaVac and receiving either a homologous booster of BBIBP-CorV or a heterologous booster of CoronaVac. Serum IgG, IgM, and Spike antibody levels against SARS-COV-2 were measured using magnetic particle chemiluminescence immunoassay and the ELISA method.
Article Synopsis
- Fdx binds iron under cold stress conditions instead of forming the [2Fe-2S] cluster, as shown by a unique absorption peak at 320 nm in UV-visible spectroscopy.
- When cold-stressed cells are returned to warmer temperatures (above 25°C), Fdx can convert from the iron-binding form to the [2Fe-2S] cluster-bound form, highlighting a temperature-dependent maturation process.
- The assembly of [2Fe-2S] clusters in Fdx is proposed to occur through a unique pathway that does not rely on other known iron-sulfur cluster assembly proteins, indicating Fdx's independent role in iron-sulfur biogenesis.