Publications by authors named "Yuko Py Lam"
Article Synopsis
- LRRK2 serine/threonine kinase is linked to inherited Parkinson's disease and modifies Rab GTPases to influence their functions.
- PPM1H, a metal-dependent protein phosphatase, specifically dephosphorylates Rab proteins that have been phosphorylated by LRRK2, counteracting its effects.
- The research reveals that a unique 110-residue flap domain in PPM1H is crucial for its selective interaction with phosphorylated Rabs, suggesting a specialized mechanism for dephosphorylation.
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