Publications by authors named "Yuko Py Lam"

Article Synopsis
  • LRRK2 serine/threonine kinase is linked to inherited Parkinson's disease and modifies Rab GTPases to influence their functions.
  • PPM1H, a metal-dependent protein phosphatase, specifically dephosphorylates Rab proteins that have been phosphorylated by LRRK2, counteracting its effects.
  • The research reveals that a unique 110-residue flap domain in PPM1H is crucial for its selective interaction with phosphorylated Rabs, suggesting a specialized mechanism for dephosphorylation.
View Article and Find Full Text PDF