Publications by authors named "Yuko Ono"
Sepsis is a severe condition with high mortality, in which immune dysfunction plays a critical role. Poor oral health has been linked to frailty, but its impact on sepsis outcomes remains unclear. Therefore, we used a mouse model of malocclusion and sepsis to investigate how tooth loss affects immune responses during sepsis.
View Article and Find Full Text PDFRoad traffic accidents are a global health concern. K-car vehicles, also known as "mini vehicles," are defined as those having an engine displacement <660 cc, vehicle length <3.4 m, width <1.
View Article and Find Full Text PDFBackground: Renal fibrosis is strongly correlated with renal functional outcomes. Therefore, this is a significant finding in determining renal prognosis. There are various reports on the imaging evaluation of renal fibrosis, but these are not well established.
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- * A kidney biopsy showed damage and the presence of 10-20 nm black granules, which resembled silica nanoparticles detected in both the functional food tablets and the patient's urine using low-vacuum scanning electron microscopy (LVSEM).
- * The study suggests that reabsorbed silica nanoparticles may cause oxidative stress, highlighting the effectiveness of LVSEM with elemental analysis in identifying causes of acute tubular necrosis associated with Fanconi syndrome.
Intratarsal Keratinous Cyst at the Eyelid Margin: A Case Report.
Ophthalmic Plast Reconstr Surg
November 2024
Article Synopsis
- A 73-year-old Asian man developed an intratarsal keratinous cyst at the lid margin after using long-term antiglaucoma eye drops, with no prior trauma or surgery.
- The cyst presented as a yellow solid mass for about 3 years, resembling sebaceous gland carcinoma or steatocystoma simplex.
- Diagnosis was confirmed through excision biopsy and histopathological analysis, marking this as the first reported case of this specific type of cyst at the eyelid margin.
Article Synopsis
- A pericardial drainage catheter can sometimes move into the right main pulmonary artery, which is a rare and serious complication.
- This issue might arise when draining fluid from the pericardial space, especially if symptoms of cardiac tamponade (pressure on the heart) continue despite treatment.
- If a lot of thick, bloody fluid is removed during the procedure, it raises the risk of this migration and potential life-threatening consequences.
Article Synopsis
- Anastomosing hemangioma (AH) is a rare type of capillary hemangioma, often found in the genitourinary tract, and can be challenging to diagnose without tissue samples.
- A 67-year-old woman with an asymptomatic retroperitoneal tumor, initially believed to be benign, underwent imaging that showed growth over 4 years, ultimately leading to surgical removal.
- The tumor was pathologically confirmed as AH, which is very rare, representing only 1-3% of retroperitoneal tumors, and highlights the need for considering it in the diagnosis of heterogeneous masses in the para-aortic region.
Article Synopsis
- Multicentric Castleman's disease (MCD) is a rare, benign condition characterized by abnormal growth of lymphoid tissue, affecting both lymph nodes and other organs; this case involves a 55-year-old man with significant kidney infiltration by IgG4+ plasma cells.* -
- The patient exhibited symptoms like high fever and diarrhea, along with lab findings including renal dysfunction, anemia, and elevated IgG4 levels, alongside lymph node enlargement observed through CT scans.* -
- Diagnosis of idiopathic MCD was confirmed through biopsies indicating plasma cell infiltration and other pathological features; treatment with tocilizumab led to sustained remission, highlighting the need for a careful diagnostic approach considering the disease's varied responses to treatment.*
Endotracheal intubation (ETI) is a common and crucial intervention. Whether the performance of ETI differs according to the sex of the laryngoscopist remains unclear. The aim of this study was to assess sex disparities in markers of ETI performance among novices using a high-fidelity simulator.
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- * Suspected drug-induced acute interstitial nephritis led to the discontinuation of the α-glucosidase inhibitor miglitol, which he had started two weeks prior.
- * A renal biopsy confirmed acute interstitial nephritis and diabetic nephropathy, and after stopping miglitol, the patient's urinary β2MG levels returned to normal, suggesting that miglitol may impair kidney function in those with pre-existing renal issues.
The concept of infection-related glomerulonephritis (IRGN) has been introduced as adults diagnosed with glomerulonephritis often have coexisting active infections. Furthermore, IgA-dominant IRGN is associated with staphylococcal infections in adults with comorbidities, which often progress to end-stage renal disease. Little is known about IgA-dominant IRGN in children, and no consensus for a management strategy of this condition has been reached.
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- - A young woman experienced repeated abdominal pain due to ileocecal endometriosis, where the endometrial tissue grows in the bowel.
- - Hormonal influences can cause this tissue to proliferate and bleed, resulting in cyclical pain in the abdomen.
- - Doctors should consider gastrointestinal endometriosis as a potential cause when reproductive-aged women report recurring abdominal pain.
Background & Aims: Malnutrition is associated with poor outcomes. Muscle mass is an important malnutrition indicator included in Global Leadership Initiative on Malnutrition (GLIM) criteria. Although bioelectrical impedance analysis and dual-energy X-ray absorptiometry are common muscle mass assessment methods, they are unreliable during intensive care unit (ICU) admission due to the influence of dynamic fluid changes.
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- The Great East Japan Earthquake of March 11, 2011, was a major natural disaster that possibly influenced gender disparities in academic publishing among researchers in affected areas.
- A study analyzed 5,873 biomedical articles published in the four years surrounding the earthquake and found a significant decline in female first authorship after the event, dropping from 20.5% to 14.1%.
- The results indicate that significant natural disasters might exacerbate existing gender inequalities in scientific publishing, contrasting with reference data from minimally affected universities that showed an opposite trend.
Article Synopsis
- A 69-year-old man experienced acute kidney injury (AKI) as acute interstitial nephritis (AIN) four days after receiving the BNT162b2 mRNA COVID-19 vaccine.
- Despite treatment with steroids, his kidney function declined, leading to hemodialysis, but later improved with confirmation of AIN through a biopsy.
- The case suggests a rare connection between the COVID-19 vaccine and the development of AIN.
Article Synopsis
- Overactivated microglia are linked to sepsis-associated encephalopathy (SAE), while the role of T cells, particularly γδT cells, remains unclear.
- In a sepsis mouse model, increased anxious behavior was observed 10 days after sepsis induction, alongside a significant rise in IL-17 mRNA and γδT cell counts in the brain at 8 days post-induction.
- Treatment with antibodies to deplete γδT cells and IL-17A improved anxious behavior and reduced microglial activation, indicating that IL-17-producing γδT cells contribute to worsening psychological effects in septic mice.
Aim: To identify whether the coronavirus disease 2019 (COVID-19) pandemic affects the operational efficiency of emergency medical services (EMS) and the survival rate of out-of-hospital cardiac arrest (OHCA) in prehospital settings.
Methods: We conducted a population-based cohort study in Kobe, Japan, between March 1, 2020, and September 31, 2022. In study 1, the operational efficiency of EMS, such as the total out-of-service time for ambulances, the daily occupancy rate of EMS, and response time, was compared between the pandemic and nonpandemic periods.
Article Synopsis
- Advances in deep learning technology have led to the creation of a computer-assisted diagnostic tool for detecting lymph node metastasis in patients with gastric adenocarcinoma using whole-slide images.
- A ResNet-152-based system was developed and tested against 70 LN images reviewed by pathologists to evaluate its effectiveness compared to traditional methods.
- Results showed that while sensitivity for detecting micrometastases improved with algorithm assistance, it took longer to review, with the algorithm achieving a performance level that can enhance pathologists' diagnostic accuracy despite some limitations.
A case of eosinophilic pancreatitis in a patient with ulcerative colitis.
Oxf Med Case Reports
February 2023
Article Synopsis
- - Eosinophilic pancreatitis (EP) is a rare condition marked by a significant presence of eosinophils in the pancreas, which can lead to inflammation.
- - A 40-year-old man who had ulcerative colitis for many years developed acute pancreatitis after starting treatment with golimumab, prompting further medical investigation.
- - A biopsy revealed eosinophil infiltration in the pancreas, leading to a diagnosis of EP, for which he was treated with corticosteroids.
Background: The kidneys are one of the organs most commonly affected by blunt trauma; however, the anatomical variations that predispose kidney injury are poorly understood.
Case Presentation: An 80-year-old Japanese woman with lumber scoliosis was brought to our hospital because of severe flank pain after a minor fall at home. Contrast-enhanced computed tomography showed a severe left kidney laceration at the level of an acute angle in the vertebral column caused by scoliosis.
Article Synopsis
- Burn injuries cause significant mortality and disability globally, leading to serious economic costs and triggering systemic inflammatory responses that result in muscle wasting.
- The study found that the STAT3-specific inhibitor C188-9 can effectively reduce muscle loss and improve grip strength in mice with burn injuries by inhibiting harmful inflammatory and proteolytic pathways influenced by high levels of IL-6.
- The findings suggest that targeting the STAT3 signaling pathway may offer a potential treatment for preventing skeletal muscle wasting in patients suffering from burn injuries.
Article Synopsis
- Sepsis can lead to significant muscle atrophy and prolonged physical dysfunction, and while macrophages' role has been studied, the impact of neutrophils in this process is less understood.
- In the experiment, sepsis was induced in mice, and various measurements including body weight, grip strength, and muscle area were taken to evaluate the effects over time and under different cecal slurry concentrations.
- Results showed reduced body weight, grip strength, and muscle fiber size in septic mice, with an initial increase in muscle-localized neutrophils that later declined, suggesting that neutrophils may play a complex role in muscle atrophy following sepsis.
Article Synopsis
- Muscle mass is crucial for illness survival, and ultrasound is gaining interest as a noninvasive, portable assessment method, though its usage remains low among healthcare providers.
- A survey of 1,026 healthcare professionals in Japan revealed that while 93% were familiar with general muscle mass assessment, only 21% had used ultrasound for this purpose.
- Key barriers to implementing ultrasound muscle mass assessments included lack of relevant education (84%), limited staff availability (61%), and no established protocols (61%), highlighting the need for more training and resources.
Article Synopsis
- Post-intensive care syndrome (PICS) affects patients after severe illnesses like sepsis, causing physical, mental, and cognitive challenges.
- In a study of sepsis patients, 70% experienced PICS at 3 months, and this decreased to 35% by 12 months, with significant impacts on survival rates.
- Two-year survival rates were notably lower for those with PICS (54%) compared to those without (94%), highlighting the serious long-term effects of PICS on health outcomes.