Publications by authors named "Yuko Meguro"
Background: Approximately 55% of patients with neuromyelitis optica spectrum disorder (NMOSD) show cognitive impairment as evaluated using the Rao Brief Repeatable Neuropsychological Battery (BRBN), but this frequency appears to be higher than the frequency of specific brain lesions in NMOSD.
Objective: We studied whether cognitive impairment could be observed in NMOSD patients with no or minor non-specific brain lesions.
Methods: We evaluated cognitive function in 12 NMOSD and 14 MS patients using the Wechsler Adult Intelligence Scale-III (WAIS-III), the Wechsler Memory Scale-Revised (WMS-R), and the BRBN.
Aims: The exacerbation of heart failure (HF) induces brain damage and cognitive impairment (CI), which frequently attenuates the effects of treatment. However, it is not clear whether HF patients without clinical dementia demonstrate increased risk of CI. We examined whether local atrophy in the parahippocampal gyrus, a potential predictor of CI, is prominent in HF patients without clinical dementia.
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- Sialidase is crucial for long-term potentiation and spatial memory, facilitating the removal of sialic acids from cell surfaces in response to neural activity.
- Increased sialidase activity linked to high-K-induced depolarization and chemical stimulation indicates a shift in sialidase localization rather than increased expression.
- High-frequency stimulation in hippocampal slices shows immediate desialylation, suggesting that sialidase plays a key role in the neural processes underlying memory formation.