Long-term follow-up of a single dose of fluralaner in nine dogs with demodicosis.

Background: Long-term follow-up of oral fluralaner for canine demodicosis has not been demonstrated.

Objectives: A multicentre prospective open trial for the efficacy of oral fluralaner for the long-term (>12 month) management of canine demodicosis.

Animals: Client-owned dogs diagnosed with demodicosis at nine veterinary clinics.

Retrospective cohort study on combination therapy with the histamine H2-receptor antagonist lafutidine for antihistamine-resistant chronic urticaria.

We conducted a retrospective cohort study evaluating the efficacy and usefulness of the addition of lafutidine, a novel histamine H2-receptor antagonist, in treatment of patients with idiopathic chronic urticaria whose disease was not well controlled with histamine H1-receptor antagonists. Based on the assessment of global improvement, moderate or better improvement was achieved in 39 of 46 patients (85%) after 1-3 weeks of additional administration of lafutidine and 35 patients (76%) after 3 months. No incidence of drug-related adverse reactions was reported in any patient.