Publications by authors named "Yuko Kurosaka"
Article Synopsis
- RAGE (receptor for advanced glycation endoproducts) inhibits chondrocyte differentiation and cartilage matrix production, with its expression found in prehypertrophic to hypertrophic regions of cartilage.
- Overexpression of RAGE negatively affects the production of important chondrocyte markers, while downregulation of certain genes (Cdxs) is key to its inhibitory effects.
- The study suggests that RAGE operates through NF-κB-independent and Rho family GTPases-dependent pathways to regulate chondrocyte differentiation during early stages of cartilage development.
