[Severe aplastic anemia exhibiting mild COVID-19 despite high serum IL-6 levels].

COVID-19 is a viral infection characterized by a cytokine storm similar to that in acute respiratory distress syndrome (ARDS). Neutrophils and monocytes are known to play an important role in tissue damage in ARDS. COVID-19 has been reported to be more severe in patients with hematological malignancies; however, there are few reports of COVID-19 in patients with aplastic anemia.

Clonal Cytopenia of Undetermined Significance in a Patient with Congenital Wilms' Tumor 1 and Acquired DNMT3A Gene Mutations.

Congenital mutations of the Wilms' tumor 1 (WT1) gene can lead to various abnormalities, including renal/gonadal developmental disorders and cardiac malformations. Although there have been many reports of somatic WT1 mutations in patients with acute myeloid leukemia and myelodysplastic syndrome, congenital WT1 mutations have not been reported in hematological disorders. We herein report a patient with early-onset clonal cytopenia of undetermined significance that was associated with a congenital mutation of WT1 and an acquired mutation of DNMT3A [encoding DNA (cytosine-5)-methyltransferase 3A].

Detailed kinetic model for hexyl sulfide pyrolysis and its desulfurization by supercritical water.

A detailed reaction network is proposed for the pyrolysis and desulfurization of hexyl sulfide in the presence or absence of both supercritical water (SCW) and hexadecane, but without any added H2 or catalyst, for T = 400-450 °C. The new kinetic model is developed using the Reaction Mechanism Generator (RMG) software where most of the rate coefficients are derived from quantum chemical calculations. We previously reported that pentane, carbon monoxide and carbon dioxide are major products of hexyl sulfide desulfurization in SCW, but not in the anhydrous pyrolysis of hexyl sulfide.

Combining experiment and theory to elucidate the role of supercritical water in sulfide decomposition.

The cleavage of C-S linkages plays a key role in fuel processing and organic geochemistry. Water is known to affect these processes, and several hypotheses have been proposed, but the mechanism has been elusive. Here we use both experiment and theory to demonstrate that supercritical water reacts with intermediates formed during alkyl sulfide decomposition.