Publications by authors named "Yuko Kaida"
Article Synopsis
- Despite the introduction of the rubella vaccine in 1977, rubella and congenital rubella syndrome (CRS) persist in Japan, highlighting flaws in the current immunization strategy.
- Universal immunization improved vaccine coverage and reduced rubella cases, but outbreaks occurred in 2012-2013 and 2018-2019 due to imported viruses and unvaccinated males.
- The study suggests that a single-dose vaccination is insufficient to fully prevent infections and CRS, emphasizing the need for a second dose to close immunization gaps and avoid future outbreaks.
Article Synopsis
- Measles is a highly contagious viral disease that has caused significant infant mortality in developing countries, but Japan successfully eliminated it by improving vaccination and surveillance systems starting in 1978 and achieving elimination in 2015.
- Between 1982 and 2021, a comprehensive analysis of measles cases in Osaka Prefecture showed that while vaccination rates increased, the average age of susceptible individuals rose, and cases shifted from infants to young adults.
- Despite high vaccination rates and seroprevalence, a decline in antibody levels due to low measles incidence has led to rising vaccine failures, highlighting the need for booster doses to maintain immunity.
Erythema infectiosum, caused by human parvovirus B19 (B19V), is difficult to diagnose by its clinical symptoms and is often misdiagnosed as measles or rubella. Timely confirmation of measles/rubella or other viral etiologies via laboratory tests can provide an accurate picture of the infection status, which can appropriate response. The purpose of this study was to determine the contribution of B19V as an etiological agent for fever-rash in suspected cases of measles and rubella in Osaka Prefecture between 2011 and 2021.
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- This study investigates the shedding of rubella virus (RuV) by analyzing samples from 251 patients with acute rubella infection to better understand how the virus is excreted over time.* -
- Results show that the highest levels of viral RNA were found shortly after the rash appeared, with infectious virus detectable in various samples for up to a few days post-rash onset.* -
- The findings support improved rubella monitoring and diagnosis, suggesting that monitoring viral RNA levels can help identify infectious patients early and prevent the spread of the virus.*
Article Synopsis
- Japan conducted a longitudinal study from 2003 to 2020 on measles-specific antibody levels to assess vaccine effectiveness during different time periods before and after the elimination of measles.
- The study found that while seroprevalence of immunity increased over time, the actual antibody titers decreased, indicating a waning immunity among the population.
- The results suggested that without natural exposure to wild measles strains, the effectiveness of vaccine-induced immunity may diminish, raising concerns about potential future susceptibility to measles in Osaka.
Electrogastrography (EGG) is a non-invasive diagnostic motility for recording gastric myoelectrical activity. Gastric myoelectrical activity was first recorded in 1922. Advances in recording equipment enabled widespread use of cutaneous EGG after 1985.
View Article and Find Full Text PDFPurpose: The present study was undertaken to clarify the effects of (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA), a metabotropic glutamate receptor (mGluR) 1 antagonist, (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate ((2R,4R)-APDC), a mGluR2/3 agonist, and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), a mGluR4/8 agonist, on pentetrazol-induced kindled seizures.
Methods: Mice were anesthetized with pentobarbital; the electrodes and guide cannula were chronically implanted into the cortex and lateral ventricle. To induce kindling, pentetrazol at a dose of 40 mg/kg was injected once every 48 h.
The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures. The mechanism of the anticonvulsant effect of AIDA was also studied. Mice were anesthetized with pentobarbital; the electrodes and guide cannula were chronically implanted into the cortex and lateral ventricle.
View Article and Find Full Text PDFA 78-year-old man underwent a radical resection for esophageal cancer (Stage III) and cardiac gastric cancer (Stage IA) at another hospital 2 years ago. After the operation, he was followed at that hospital. In 2008, abdominal CT scan and FDG-PET/CT revealed a liver tumor.
View Article and Find Full Text PDFPurpose: The present study was undertaken to clarify the behavioral and electroencephalographic characteristics of olfactory bulb (OB) kindling in rats, in comparison with those of amygdala (AMG) kindling. In addition, the usefulness of OB kindling as a model to evaluate antiepileptics was studied.
Methods: Bipolar electrical stimulation was applied to the OB or AMG every day until generalized seizure was achieved.