Publications by authors named "Yuko Goto"

Article Synopsis
  • - Fullerene whiskers (FLWs) and fullerenes (FLs) are rod-like structures made of carbon, and their shape raises concerns about potential health risks similar to those posed by asbestos and carbon nanotubes, but no long-term studies on their carcinogenic effects have been conducted.
  • - In a study, male rats were given FL, FLW, and different types of multi-walled carbon nanotubes (MWCNT) to assess lung and pleural carcinogenicity, leading to analyses at 1 and 104 weeks post-exposure.
  • - Results showed that while MWCNT exposure led to significant increases in lung tumors and oxidative DNA damage, FL and FLW did not induce carcinogenic effects in the
View Article and Find Full Text PDF
Article Synopsis
  • A study on the carcinogenicity of anatase-type nano-titanium dioxide (aNTiO) involved exposing F344/DuCrlCrlj rats to different aerosol concentrations for two years.
  • The results showed that while bronchiolo-alveolar carcinomas appeared in two males exposed to the highest concentration, this finding was not significantly higher than historical control data.
  • Non-cancerous lung lesions were noted, and the aNTiO levels in the lungs of rats decreased over time after exposure, leading to the conclusion of equivocal evidence for aNTiO's carcinogenicity.
View Article and Find Full Text PDF

Background: Well Parent Japan (WPJ) is a new hybrid group parent training programme combining sessions to improve mothers' psychological well-being with a culturally adapted version of the New Forest Parenting Programme (NFPP). This study investigates the effectiveness and cost-effectiveness of WPJ against treatment as usual (TAU) within Japanese child mental health services.

Methods: TRANSFORM was a pragmatic multi-site randomised controlled trial (RCT) with two parallel arms.

View Article and Find Full Text PDF

Advance care planning (ACP) has attracted increasing research attention in recent years. In Japan, extensive training has been conducted to improve communication through workshops, such as role-playing. In training, including trainee-centered work, the facilitator who assists trainee learning plays an important role.

View Article and Find Full Text PDF

Older adult patients account for 70% of all hospitalized patients in Japan, and intermediate care based on patient-centered care (PCC) that ensures continuity and quality of care at the interface between home services and acute care services and restores patient's independence and confidence is necessary for them to continue living independently. At present, no concept of intermediate care is established in Japan, and the implementation of PCC has been delayed. Thus, in this study, a Japanese version of the intermediate care evaluation index (patient-reported experience measure (PREM)) was created on the basis of the original PREM developed in the UK, and data in wards with intermediate care functions in Japan were collected to confirm internal consistency and validity from 2020 to 2022.

View Article and Find Full Text PDF

Objectives: This study aimed to investigate the relationship between the use of inpatient respite care and the overall survival of homebound patients without cancer admitted to a hospital ward in order to assess the potential impact of inpatient respite care on the duration of home care.

Design: This was a single-centre, hospital ward-based retrospective observational study.

Setting And Participants: From March 2011 to September 2018, 393 cancer-free older patients (median age, 84.

View Article and Find Full Text PDF

Objective: This study investigated and compared the implementation of life-support treatment (LST), cardiopulmonary resuscitation (CPR) implementation rates, and the influence of acute illnesses on the introduction of palliative care (PC) to homebound patients with malignant and nonmalignant disease, who subsequently died in an acute hospital setting.

Methods: Among the homebound patients admitted to the ward in our hospital from 2011 to 2018, we investigated and compared the attributes, underlying diseases, causes of death, and rates of implementation of LST, CPR, and PC between patients with malignant and nonmalignant disease who died in the ward, using data obtained from hospitalization records. Furthermore, acute illnesses related to the introduction of PC were examined.

View Article and Find Full Text PDF

Dysphagia occurs in various diseases and constitutes a major concern in patients with psychiatric disorders. The Mann Assessment of Swallowing Ability (MASA) comprises 24 clinical parameters designed to identify swallowing disorders. One item in MASA, the "gag reflex", involves an unpleasant stimulus, which means that it is often omitted when the test is administered.

View Article and Find Full Text PDF

Aim: This study evaluated an advanced care planning (ACP) training program incorporating online skills in shared decision making (SDM).

Method: The New World Kirkpatrick Model was employed to assess the efficacy of the training program at four levels: reaction, learning, behavior, and results. Reaction measured the participants' satisfaction and difficulty with the training program alongside the status of support received from workplaces engaging in ACP.

View Article and Find Full Text PDF

Clarifying the effect of the sampling protocol on the detection of environmental DNA (eDNA) is essential for appropriately designing biodiversity research. However, technical issues influencing eDNA detection in the open ocean, which consists of water masses with varying environmental conditions, have not been thoroughly investigated. This study evaluated the sampling effort for the metabarcoding-based detection of fish eDNA using replicate sampling with filters of different pore sizes (0.

View Article and Find Full Text PDF
Article Synopsis
  • Six workers in a Japanese chemical plant developed interstitial lung diseases linked to inhalation of cross-linked water-soluble acrylic acid polymers (CWAAPs), prompting this study on lung damage in rats.
  • The study involved exposing male rats to CWAAPs through inhalation and intratracheal instillation, analyzing lung tissues and fluids for damage and cellular responses.
  • Results showed that both single and repeated exposures led to alveolar injury and changes in lung tissue, with some lesions healing and others progressing to more severe conditions like alveolitis.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess the cancer-causing effects of 2-bromopropane (2-BP) in rats through inhalation exposure over two years.
  • Male and female F344 rats were exposed to varying concentrations of 2-BP, with those exposed to the highest level experiencing severe health issues and dying from tumors.
  • The research found a significant increase in various types of tumors in the rats, suggesting that 2-BP poses a risk of being a carcinogen to humans as well.
View Article and Find Full Text PDF

Objectives: Malnutrition in cancer-free older patients receiving home medical care may affect prognosis, but indicators of long-term nutrition-related prognosis have not been developed. This study investigated the utility of the Controlling Nutritional Status (CONUT) score as a prognostic factor for older patients without cancer receiving home medical care.

Design: This was a single-centre, hospital ward-based observational cohort study.

View Article and Find Full Text PDF

2-Bromopropane (2-BP) is a colorless liquid at room temperature and is used in closed systems in factories, mainly as an intermediate for medicines, pesticides, and other chemicals. However, the carcinogenicity of 2-BP is still unknown. The CByB6F1-Tg(HRAS)2Jic (rasH2) transgenic mouse model has been established as an alternative to long-term studies (1.

View Article and Find Full Text PDF

To support patients in making complex and difficult decisions, it is necessary to form a team that comprises different specialists, the patient, and family members who have detailed information about the latter. Shared decision-making (SDM) is the foundation of patient-centered care; however, its structure in the context of multidisciplinary teams remains unclear. This cross-sectional study aimed to validate the novel interprofessional SDM measure ("Group's SDM measure").

View Article and Find Full Text PDF

The Japanese long-term care insurance system came into operation in the year 2000 and the chief care manager certification system was established in 2006 to improve the quality of care management. Certified chief care managers are expected to perform the role of a specialist. The purpose of this study was to determine the impact of the chief care manager certificate in coordination with hospitals.

View Article and Find Full Text PDF

Background: Most toxicological studies on titanium dioxide (TiO) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and interstitial lung diseases caused by particle-laden macrophages. The present study examined rat pulmonary lesions associated with pneumoconiosis after inhalation exposure to TiO nanoparticles (NPs).

Methods: Male and female F344 rats were exposed to 6.

View Article and Find Full Text PDF

With the rapid development of alternative methods based on the spirit of animal welfare, the publications of animal studies evaluating endpoints such as cancer have been extremely reduced. We performed a 26-week inhalation exposure studies of titanium dioxide nanoparticles (TiO NPs) using CByB6F1-Tg(HRAS)2Jic (rasH2) mice model for detecting carcinogenicity. Male and female rasH2 mice were exposed to 2, 8 or 32 mg/m of TiO NPs for 6 h/day, 5 days/week for 26 weeks.

View Article and Find Full Text PDF

Due to the rapidly aging population in Japan, the government has been attempting to link the healthcare delivery system with the long-term care delivery system. However, there are complex challenges that must be overcome to link the two systems. A new methodology should be used to organize complex community challenges and propose solutions.

View Article and Find Full Text PDF

Background: We developed a novel training program for health care professionals that incorporated shared decision making (SDM) skills training into an advance care planning (ACP) training course, the first in Japan. This study aimed to assess the training program's impact on health care professionals' knowledge, skill, attitudes, and confidence to initiate ACP.

Methods: Using the novel Japanese educational program, we evaluated the effect of 8-month programs conducted eight community training sites of professionals who can practice ACP in a local area in Aichi Prefecture (the Aichi ACP Project).

View Article and Find Full Text PDF

In Japan, shared decision-making (SDM) is still in its infancy, and there are many challenges and missions in promoting SDM. Older people account for approximately 30% of the population of Japan and they experience several challenges in deciding about the treatment and care for themselves. The importance of specific decision support and patient involvement is yet to be recognized widely for difficult decisions.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigated the carcinogenic effects of multiwalled carbon nanotubes (MWCNTs), specifically MWNT-7, on rats over a 2-year period, using both inhalation and intratracheal instillation methods for exposure.
  • - Findings showed significant increases in lung weight and various lung and pleural lesions, with higher incidences of lung tumors and pleural mesotheliomas in the high-dose group compared to controls.
  • - The results concluded that repeated exposure to MWNT-7 is carcinogenic to the lung and pleura in rats, highlighting potential risks associated with MWCNTs.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionlvp9vemf5rk8qorjsmq7ag05mla76gkt): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once