Publications by authors named "Yuko Ebata"

Opioids are almost mandatorily used for analgesia for cancer pain and postoperative pain. Opioid analgesics commonly induce nausea as a side effect. However, the genetic factors involved are still mostly unknown.

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Aim: Abundant data are available on the effect of the A118G (rs1799971) single-nucleotide polymorphism (SNP) of the μ-opioid receptor OPRM1 gene on morphine and fentanyl requirements for pain control. However, data on the effect of this SNP on intraoperative remifentanil requirements remain limited. We investigated the effect of this SNP on intraoperative remifentanil requirements.

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Phantom tooth pain (PTP) is one type of non-odontogenic neuropathic toothache, which rarely occurs after appropriate pulpectomy or tooth extraction. The cause of PTP is unknown. We investigated pain-related genetic factors that are associated with PTP.

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Patients with chronic pain are affected psychologically and socially. There are also individual differences in treatment efficacy. Insufficient research has been conducted on genetic polymorphisms that are related to individual differences in the susceptibility to chronic pain.

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Article Synopsis
  • Individual differences in postoperative nausea and vomiting (PONV) led to a genome-wide association study (GWAS) involving 806 patients who underwent elective surgery with general anesthesia.
  • The study identified specific single-nucleotide polymorphisms (SNPs), such as rs2776262 and rs140703637, linked to increased nausea, as well as additional SNPs for patients who received propofol.
  • Findings may help predict those at risk for PONV and improve prophylactic treatments in the future.
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Phantom tooth pain (PTP) is a rare and specific neuropathic pain that occurs after pulpectomy and tooth extraction, but its cause is not understood. We hypothesized that there is a genetic contribution to PTP. The present study focused on the gene, which encodes the α1C subunit of the Ca1.

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Article Synopsis
  • * A genome-wide association study (GWAS) of 350 patients undergoing surgery aimed to find SNPs that influence the minimum effective concentration (MEC) of fentanyl post-op.
  • * The study found that the SNP rs966775 was linked to higher MECs of fentanyl, with its minor G allele associated with increased dosages; this has implications for personalized pain management in recovery.
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Chronic pain is reportedly associated with the transient receptor potential canonical 3 () gene. The present study examined the genetic associations between the single-nucleotide polymorphisms (SNPs) of the gene and chronic pain. The genomic samples from 194 patients underwent linkage disequilibrium (LD) analyses of 29 SNPs within and around the vicinity of the gene.

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Article Synopsis
  • * The study identified two specific single-nucleotide polymorphisms (SNPs) in the ANGPT1 gene, which were significantly associated with the amount of opioids required for pain relief (p < 5.0000 × 10−8).
  • * The results suggest that these SNPs and others could be used as indicators for predicting the effectiveness of opioid treatments in cancer pain management, paving the way for more personalized approaches to pain therapy.
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Considerable individual differences are widely observed in the sensitivity to opioid analgesics. We focused on rs12496846, rs698705, and rs10052295 single-nucleotide polymorphisms (SNPs) in the C3orf20, SLC8A2, and CTNND2 gene regions that we previously identified as possibly associated with postoperative analgesia after orthognathic surgery. We investigated associations between these SNPs and postoperative analgesia in 112 patients who underwent major open abdominal surgery in hospitals and were treated with analgesics, including opioids, after surgery.

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Phantom tooth pain (PTP) is a rare and specific neuropathic pain that occurs after pulpectomy and tooth extraction, but its cause is not understood. We hypothesized that there is a genetic contribution to PTP. We focused on solute carrier family 17 member 9 (SLC17A9)/vesicular nucleotide transporter (VNUT) and purinergic receptor P2Y12 (P2RY12), both of which have been associated with neuropathic pain and pain transduction signaling in the trigeminal ganglion in rodents.

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Pain sensitivity differs individually, but the mechanisms and genetic factors that underlie these differences are not fully understood. To investigate genetic factors that are involved in sensing cold pain, we applied a cold-induced pain test and evaluated protease-activated receptor 2 (PAR2/F2RL1) and transient receptor potential melastatin 8 (TRPM8), which are related to pain. We statistically investigated the associations between genetic polymorphisms and cold pain sensitivity in 461 healthy patients who were scheduled to undergo cosmetic orthognathic surgery for mandibular prognathism.

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Aim: Interleukin-17A (IL-17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions. IL-17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of IL-17A to pain-related phenotypes in humans, we investigated the association between pain-related phenotypes and the rs2275913 single-nucleotide polymorphism (SNP) of the IL-17A gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers.

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