Publications by authors named "Yukino Nawa"
Article Synopsis
- The study investigates the effectiveness of testing cerebrospinal fluid (CSF) for anti-HTLV-1 antibodies in diagnosing HTLV-1-associated myelopathy (HAM), highlighting the diagnostic accuracy of various test kits.
- It found that while CSF antibody levels were stable when refrigerated, they were affected by freeze-thaw cycles, leading to strong correlations in test results across different methods used on samples from 92 patients (69 with HAM, 23 carriers).
- The results showed high diagnostic performance for HAM, with five test kits achieving 100% sensitivity and varying specificity, suggesting that these tests combined with clinical evaluation can improve HAM diagnosis.
Tryptophan hydroxylase 2 (TPH2) is the key enzyme in the synthesis of neuronal serotonin. Although previous studies suggest that TPH2 neuron-restrictive silencer element (NRSE) functions as a negative regulator dependent on neuron-restrictive silencer factor (NRSF) activity, the underlying mechanisms are yet to be fully elucidated. Here, we show a detailed analysis of the NRSE-mediated repression of the human TPH2 (hTPH2) promoter activity in RN46A cells, a cell line derived from rat raphe neurons.
View Article and Find Full Text PDFIn the title compound, C10H19N3O4, the N- and C-termini are protonated and ionized, respectively, and the mol-ecule forms a zwitterion. The main chain is in a folded form. In the crystal, the N-terminal -NH3 (+) group hydrogen bonds to three C-terminal -COO groups and one carbonyl O atom, forming a three-dimensional network.
View Article and Find Full Text PDFSerotonin (5-HT) is a neurotransmitter involved in many aspects of the neuronal function. The synthesis of 5-HT is initiated by the hydroxylation of tryptophan, catalyzed by tryptophan hydroxylase (TPH). Two isoforms of TPH (TPH1 and TPH2) have been identified, with TPH2 almost exclusively expressed in the brain.
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