Publications by authors named "Yukiko Takayama"
Article Synopsis
- - The study investigates the effectiveness of S-1, a drug used after surgery for biliary tract cancer, and its relationship with certain genes involved in the metabolism of the chemotherapy drug 5-fluorouracil (5-FU).
- - Researchers analyzed tumor samples from 183 patients and categorized them based on their DPD and TP gene levels to see how these affected recurrence-free survival (RFS) when treated with S-1.
- - Findings indicated that patients with low levels of DPD and TP genes had better RFS benefits from adjuvant S-1, highlighting the potential prognostic significance of these genes in treatment outcomes.
Background: The natural history of branch-duct intraductal papillary mucinous cystic neoplasms (BD-IPMNs) in the pancreas remains unclear. This study aimed to answer this clinical question by focusing on the development of concomitant pancreatic ductal adenocarcinomas (cPDAC).
Methods: The Japan Pancreas Society conducted a prospective multicenter surveillance study of BD-IPMN every six months for five years.
We treated a 39-year-old Japanese man who was admitted for an abdominal mass. He had had neurofibroma-like skin lesions since childhood. Computed tomography and endoscopic ultrasound results were consistent with a tumor in the small intestine.
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- A study was conducted to compare the effectiveness of two cancer treatments—mFOLFIRINOX and GnP—specifically for patients with locally advanced pancreatic cancer (LAPC).
- The trial included 126 patients, assessing outcomes like overall survival and how well the cancer responded to treatment, with GnP showing superior response rates and lower toxicity.
- The study concluded that GnP should be tested in further research due to its better overall performance compared to mFOLFIRINOX, marking progress over traditional gemcitabine treatments.
Article Synopsis
- Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is essential for diagnosing pancreatic tumors, and this study focused on needle tract seeding (NTS) occurrences post-EUS-TA in Japan.
- A survey of over 12,000 patients revealed an overall NTS incidence of 0.330%, notably higher in those with pancreatic ductal adenocarcinomas (PDACs) compared to other tumors.
- NTS was only found after transgastric procedures, with the majority located in the gastric wall, and patients who underwent resection of NTS lesions had significantly better survival rates.
Article Synopsis
- The study investigates the role of lymphatic, microvascular, and perineural invasion as prognostic factors in the recurrence of pancreatic neuroendocrine neoplasms (PanNENs) among 138 patients who underwent surgery.
- Findings reveal that 17% of patients experienced recurrence, with significant risk factors identified as a tumor grade of 2-3 and the presence of microvascular invasion.
- Ultimately, the research concludes that microvascular invasion is a key independent risk factor for recurrence in PanNEN patients.
Preoperative treatment is being proposed as a standard treatment for pancreatic ductal adenocarcinoma though few cases show a pathologically complete response. On the other hand, there is no consensus regarding preoperative chemotherapy for pancreatic acinar cell carcinoma (ACC). The present study described a rare case of ACC in the pancreatic head with portal vein tumor thrombosis (PVTT) treated with preoperative chemotherapy using modified FOLFIRINOX, which achieved a pathologically complete response.
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- The study investigates a new integrated communication support program to enhance communication between oncologists, patients with advanced cancer, and their caregivers.
- It involves a randomized control trial with 20 oncologists and 200 patients in Japan, where oncologists receive training on communication skills while patients and caregivers get coaching to discuss their concerns.
- The study follows ethical guidelines and aims to evaluate improvements in patient-centered communication behaviors over a 3-year period.
Gemcitabine plus nab-paclitaxel vs. FOLFIRINOX for patients with advanced pancreatic cancer.
Cancer Chemother Pharmacol
August 2018
Purpose: New chemotherapies have become available for the treatment of advanced pancreatic cancer and have led to changes in its standard treatments. Since pancreatic cancer is becoming more common as a result of population aging, there is a need for diversification of chemotherapy.
Methods: Between March 2014 and April 2017, FOLFIRINOX (FFX) or gemcitabine plus nab-paclitaxel (G-nab) was used as first-line therapy to treat 27 patients with locally advanced and metastatic pancreatic cancer at our hospital.
Article Synopsis
- This study compares endoscopic nasobiliary drainage (ENBD) and endoscopic biliary stent (EBS) as preoperative treatments for hilar malignant biliary obstruction (MBO) using data from 374 cases across 29 centers.
- The research found that while ENBD had a high technical success rate (94.6%), 21.9% of patients experienced adverse events, and over half (61.5%) required preoperative re-interventions, mostly unplanned.
- Ultimately, the analysis suggests that ENBD does not offer significant advantages over EBS, and unplanned re-interventions are linked to poorer outcomes for patients with resectable hilar MBO.
Article Synopsis
- * Involving 47 AIP patients, researchers calculated the change in IgG4 levels from before treatment to 2 months after starting steroids and assessed the rate of decrease.
- * Results indicated that a higher rate of decrease in IgG4 levels was associated with a lower chance of relapse, suggesting it could be a useful predictor of relapse risk after stopping steroid therapy.
Bifidobacterium pseudocatenulatum JCM 1200(T) was isolated from infant feces. This paper is the first report demonstrating the fully sequenced and completely annotated genome of a B. pseudocatenulatum strain.
View Article and Find Full Text PDFBifidobacterium dentium strain JCM 1195(T) was isolated from human dental caries. Here, we report the complete genome sequence of this organism.
View Article and Find Full Text PDFIn the present study, we investigated auditory event-related potentials in adults with Asperger disorder and normal controls using an auditory oddball task and a novelty oddball task. Task performance and the latencies of P300 evoked by both target and novel stimuli in the two tasks did not differ between the two groups. Analysis of variance revealed that there was a significant interaction effect between group and electrode site on the mean amplitude of the P300 evoked by novel stimuli, which indicated that there was an altered distribution of the P300 in persons with Asperger disorder.
View Article and Find Full Text PDFA 53-year-old woman was referred to our hospital for management of gastric varices that ran transversely across the greater curvature of the gastric body, detected during routine upper gastrointestinal endoscopy. CT identified a low-density calcified mass near the tail of the pancreas and the splenic hilum. Based on the results of radiographic and pathological investigations, the tumor was diagnosed as solid pseudopapillary neoplasm (SPN), and the gastric varices were considered to have developed secondary to occlusion of the splenic vein by the tumor mass.
View Article and Find Full Text PDFIt is crucial to differentiate between nonneoplastic and neoplastic cysts of the pancreas by images. An epidermoid cyst in intrapancreatic accessory spleen (IPAS) is a rare pancreatic cyst that should be managed nonsurgically as well as other nonneoplastic cyst. However, the imaging features of an epidermoid cyst in IPAS have not been organized.
View Article and Find Full Text PDFAppropriate resources and expression technology necessary for human proteomics on a whole-proteome scale are being developed. We prepared a foundation for simple and efficient production of human proteins using the versatile Gateway vector system. We generated 33,275 human Gateway entry clones for protein synthesis, developed mRNA expression protocols for them and improved the wheat germ cell-free protein synthesis system.
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