Publications by authors named "Yukiko Sorayama"
The extracellular matrix (ECM) of cancer tissues is rich in dense collagen, contributing to the stiffening of these tissues. Increased stiffness has been reported to promote cancer cell proliferation, invasion, metastasis, and prevent drug delivery. Replicating the structure and mechanical properties of cancer tissue in vitro is essential for developing cancer treatment drugs that target these properties.
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- The study focuses on creating an in vitro model of liver sinusoidal structures to better assess risks of diseases like sinusoidal obstruction syndrome (SOS), which current models struggle with due to a lack of realistic vascular features.
- Researchers developed a vascularized hepatic tissue (VHT) using an innovative technique called CAViTs, resulting in significant self-assembly of cells and enhanced functions, such as a fourfold increase in albumin secretion compared to traditional 2D cultures.
- The VHT model demonstrated greater sensitivity for evaluating vascular toxicity when exposed to SOS-inducing compounds, proving its potential as an effective tool for early screening of hepatotoxicity-related risks.