The Features and Treatment Effects on Keratoepitheliopathy for Meibomitis-Related Keratoconjunctivitis.

Meibomitis-related keratoconjunctivitis (MRKC) is characterized by meibomitis with corneal epithelial abnormalities, and can be divided into two types: MRKC accompanied with phlyctenular keratitis, and MRKC accompanied with keratoepitheliopathy that is similar to superficial punctate keratopathy (SPK). The purpose of this retrospective study was to investigate the characteristic features of keratoepitheliopathy and treatment outcomes for MRKC. This study involved 27 eyes of 18 MRKC patients (3 males and 15 females).

Eye Pain Caused by Epithelial Damage in the Central Cornea in Aqueous-Deficient Dry Eye.

In this study, the severity of eye pain (EP) and associated objective findings were evaluated in aqueous-deficient dry eye (ADDE) patients using PainVision, a quantitative pain-measuring device. This study involved 53 eyes of 53 ADDE patients (6 males and 47 females; mean age: 64.4 ± 13.

Effect of Punctal Occlusion on Blinks in Eyes with Severe Aqueous Deficient Dry Eye.

Punctal occlusion (PO) is considered to improve both tear-film instability and increased friction during blinking and may consequently affect blinks. The purpose of this study was to investigate the effect of PO on blinks. This study involved 16 eyes of 16 severe aqueous deficient dry eye (ADDE) patients (mean age: 65.

Clinical Factors for Determining the Severity of Lid Wiper Epitheliopathy in Dry Eye.

Purpose: Lid wiper epitheliopathy (LWE) is an epitheliopathy of the marginal conjunctival portion of the eyelids that wipes the ocular surface during blinking. Although LWE is often observed in patients with dry eye, the factors determining LWE severity in dry eye remain unknown. Therefore, we investigated the relationship between LWE, tear abnormalities, and blinks in dry eye.

Clinical Implication of Patchy Pattern Corneal Staining in Dry Eye Disease.

Corneal fluorescein staining in a form that is commonly called a "patchy pattern (PP)" is sometimes seen with or without superficial punctate keratopathy (SPK) in dry-eye diseases (DEDs). Here, we investigated the differences in the clinical features of DED patients with and without PP corneal staining (PPCS). This study involved 35 DEDs with PPCS (PPCS group) and 30 DEDs with SPK and without PPCS (non-PPCS group).

The Relationship between Subjective Symptoms and Quality of Life in Conjunctivochalasis Patients.

The purpose of this study was to evaluate the differences in subjective symptoms between patients with conjunctivochalasis (CCh) and dry eye (DE), and examine the relationship between subjective symptoms and quality of life (QOL). In 75 eyes of 75 CCh patients and 122 eyes of 122 DE patients, 12 subjective symptoms classified into four groups depending on the mechanisms associated with symptoms (ITF: instability of tear film, IF: increased friction, R: reflex, and DTC: delayed tear clearance) were evaluated by use of a visual analogue scale (VAS). Fifteen items related to DE symptoms and their influence on daily life were evaluated by use of the dry eye-related quality-of-life score (DEQS) questionnaire, with overall degree of QOL impairment calculated as a QOL score.

Evaluation of Eye-Pain Severity between Dry-Eye Subtypes.

The aim of this study was to assess eye pain between dry eye (DE) subtypes using questionnaires and the PainVision (Osachi) apparatus. This study involved 52 eyes of 52 DE patients with eye pain (43 females and 9 males; mean age: 64.2 ± 13.

Relationship Between Ocular Surface Epithelial Damage, Tear Abnormalities, and Blink in Patients With Dry Eye.

Purpose: Considering that tears play the role of a lubricant, it is speculated that in the pathophysiology of dry eye, increased friction during blinking results in corneal and conjunctival damage, which may subsequently affect the blink. The purpose of this study was to investigate the relationship between ocular surface epithelial damage, tear abnormalities, and blinks in patients with dry eye.

Methods: This study involved 45 eyes of 45 female patients with dry eye (mean age: 57.

Classification of Fluorescein Breakup Patterns: A Novel Method of Differential Diagnosis for Dry Eye.

Purpose: To investigate the relationship between fluorescein breakup patterns (FBUPs) and clinical manifestations in dry eye cases.

Design: Cross-sectional study.

Methods: In 106 eyes of 106 subjects (19 male, 87 female; mean age: 64.

The association of sleep quality with dry eye disease: the Osaka study.

Purpose: To investigate the association of dry eye disease with sleep quality.

Methods: In 2011, a cross-sectional survey was conducted among all the employees, mainly young and middle-aged Japanese office workers, who used visual display technology, at a company in Osaka, Japan (N=672; age range =26-64 years). The participants were classified according to the Japanese dry eye diagnosis criteria by dry eye examination results including the Schirmer test, fluorescein and lissamine green staining, tear film break-up time, and symptom questionnaire into three groups as follows: definite dry eye disease, probable dry eye disease, and no dry eye disease.

Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers.

The first aim of this study was to clarify whether cigarette smoking affects tear secretion, goblet cell density, and tear MUC5AC concentration. The second purpose was to evaluate the correlations of conjunctival goblet cell density with tear MUC5AC concentration and other ocular surface evaluation factors. This cross-sectional study included 88 office workers.

Associations between subjective happiness and dry eye disease: a new perspective from the Osaka study.

Importance: Dry eye disease has become an important health problem. A lack of concordance between self-reported symptoms and the outcome of dry eye examinations has raised questions about dry eye disease.

Objective: To explore the association between subjective happiness and objective and subjective symptoms of dry eye disease.

Importance of tear film instability in dry eye disease in office workers using visual display terminals: the Osaka study.

Purpose: To evaluate the relationship between subjective symptoms and clinical signs in dry eye disease (DED) in office workers using visual display terminals (VDTs).

Design: Cross-sectional study.

Methods: This study involved 672 Japanese young and middle-aged office workers who use VDTs.

The Association between Dry Eye Disease and Physical Activity as well as Sedentary Behavior: Results from the Osaka Study.

Purpose. To assess the association of dry eye disease (DED) with physical activity and sedentary behavior. Methods.

[Treatment progress of large-size puncta and clinical investigation of the extrusion rate and other complications associated with large-size punctal plugs].

Purpose: One complication of punctal plug occlusion (PPO) is enlargement of the punctum. The purpose of the present study was to investigate large-size (over 1.0 mm) puncta after punctal plug extrusion.

[Clinical investigation of extrusion rate and other complications associated with Punctal Plug F].

Purpose: To investigate the effectiveness, extrusion rate and other complications of Punctal Plug F (PPF) compared with Punctal Plug (PP), Super-Flex plug (SFP) and SuperEagle plug (SEP).

Subjects And Methods: This study involved 31 eyes of 24 dry-eye patients treated with PPF at the dry-eye clinic of Kyoto Prefectural University of Medicine, Kyoto, Japan. Intracanalicular migration rate, extrusion rate, granulation rate, accumulation of soft whitish material and enlargement of punctum size after punctal-plug extrusion were investigated and compared with previously published results of PP, SFP and SEP.

Alteration of tear mucin 5AC in office workers using visual display terminals: The Osaka Study.

Importance: There are limited reports on the relationship between mucin 5AC (MUC5AC) concentrations in tears, working hours, and the frequency of ocular symptoms in visual display terminal (VDT) users. This investigation evaluated these relationships among patients with dry eye disease (DED) and individuals serving as controls.

Objective: To determine the relationship between MUC5AC concentration in the tears of VDT users based on the diagnosis of DED and frequency of ocular symptoms.

Dry-eye screening by using a functional visual acuity measurement system: the Osaka Study.

Purpose: We determined whether functional visual acuity (VA) parameters and a dry eyes (DEs) symptoms questionnaire could predict DEs in a population of visual terminal display (VDT) users.

Methods: This prospective study included 491 VDT users from the Osaka Study. Subjects with definite DE, diagnosed with the presence of DE symptoms, tear abnormality (Schirmer test ≤ 5 mm or tear breakup time [TBUT] ≤ 5 seconds), and conjunctivocorneal epithelial damage (total staining score of ≥3 points), or probable DE, diagnosed with the presence of two of them, were assigned to a DE group, and the remainder to a non-DE group.

Dry eye disease and work productivity loss in visual display users: the Osaka study.

Purpose: To estimate the impact of dry eye disease (DED) on work performance and productivity in office workers using visual display terminals (VDTs).

Design: Cross-sectional study.

Methods: Six hundred seventy-two Japanese young and middle-aged office workers using VDTs completed a questionnaire that was designed to measured at-work performance deficits and productivity losses using the Japanese version of the Work Limitations Questionnaire, completed by e-mail.

Prevalence of dry eye disease and its risk factors in visual display terminal users: the Osaka study.

Purpose: To investigate tear function and prevalence of dry eye disease (DED) in visual display terminal (VDT) users.

Design: Cross-sectional study.

Methods: Six hundred and seventy-two young and middle-aged Japanese office workers who used VDT completed questionnaires and underwent dry eye testing.

[Clinical investigation of the extrusion rate and other complications of the SuperEagle plug].

Purpose: Punctal occlusion using a silicone plug is reported as an effective way of treating severe dry eye. The purpose of this study is to investigate the migration, extrusion rate and complications of the SuperEagle plug (Eagle Vision)

Subjects And Methods: This study involved 148 puncta in 64 eyes of 85 patients (13 eyes of 10 men, 72 eyes of 54 women; mean age: 57.8 +/- 16.

[Clinical characteristics of short tear film breakup time (BUT) -type dry eye].

Purpose: To evaluate the clinical characteristics and management of short tear film breakup time (BUT) -type dry eye.

Methods: Clinical background and post-treatment changes of symptoms in 77 patients with short BUT -type dry eye were investigated. Treatment consisted of artificial-tear eye-drop instillation and, if necessary, the addition of a low-density-level steroid, hyaluronic acid, a low-density-level cyclopentolate prepared by ourselves and punctal plugs inserted into the upper and lower lacrimal puncta.

[Clinical course and macular retinal circulation of macular retinal epithelium atrophy].

Purpose: To investigate the clinical course of age-related maculopathy that mainly consists of retinal pigment epithelial abnormality and macular retinal circulation between the affected eye and the fellow normal eye.

Patients And Methods: Seventeen patients (19 eyes) with age-related maculopathy were followed for more than two years. We investigated visual acuity, ocular fundus appearance, and fundus angiographic findings.