Publications by authors named "Yukiko Shima"
Prior reports described cases of lymphoproliferative diseases occurring after methotrexate (MTX) administration, which are called methotrexate-associated lymphoproliferative disorders (MTX-LPDs). It has become clear that these lymphoproliferative diseases also occur following treatment with other immunosuppressive drugs, and they have been termed as other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPDs). In most of these cases, the duration of immunosuppressive drugs is very long, on the order of years.
View Article and Find Full Text PDFDiagnostic value of the serum lactate level as a predictor of bacteremia in patients with acute cholangitis.
J Hepatobiliary Pancreat Sci
August 2023
Article Synopsis
- * Analyzing 138 patients, the study found 71 had positive bacteremia, with Lac proving to be a significant predictor for this condition, showing a sensitivity of 69% at a cutoff value of 17 mg/dL.
- * The results emphasize the importance of measuring Lac in patients with AC, as those with high Lac levels were more likely to have bacteremia, linking it to a greater risk of mortality.
Introduction And Objectives: Acute cholangitis, which is characterized by biliary infection and acute liver injury, may impact cirrhosis prognosis. However, the prognosis itself remains unclear.
Materials And Methods: This multicenter retrospective cohort study compared the mortality and liver function change between patients with and without cirrhosis who underwent endoscopic treatment for acute cholangitis caused by choledocholithiasis between January 2004 and December 2019.
Article Synopsis
- Peroral cholangioscopy (POCS) enhances the diagnostic evaluation of indeterminate biliary stricture and tumor spread when used alongside computed tomography (CT) imaging.
- A study of 52 patients showed that the addition of POCS significantly improved the confident diagnosis rate compared to CT alone, particularly in identifying malignant conditions.
- Although POCS provided better visual confirmation for biliary strictures, there was no notable difference in the accuracy of tumor spread diagnosis between the two methods.
Background/objectives: Recently, increase in cell-free DNA (cfDNA) concentration or newly detected KRAS mutation after endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) biopsy were reported to be related to the occurrence of new distant metastasis. In this study, we investigated whether cfDNA concentration increased with the release of tumor components into the blood after EUS-FNA and whether its increase was related to prognosis.
Methods: Sixty-eight patients underwent EUS-FNA and were pathologically confirmed as having pancreatic ductal adenocarcinoma (PDAC).
Aim: To evaluate the effects of early (≤6 months after starting any medical treatment [baseline] for benign prostatic hyperplasia [BPH]), intermediate (between >6 months and 2 years from baseline) and late (2 years after baseline) initiation of add-on dutasteride therapy on the incidence of acute urinary retention (AUR) and BPH-related surgery in Japanese patients with moderate-to-severe BPH.
Methods: This multicentre, observational, retrospective chart review study used anonymised data from Japanese medical records. Eligible patients (≥50 years) were followed from baseline until first AUR, BPH-related surgery or Year 4.